Dr. Gallo is a Professor in the Rutgers-Robert Wood Johnson Medical School Department of Environmental and Occupational Medicine. He is a Diplomate of the American Board of Toxicology, and a Fellow of the Academy of Toxicological Sciences. Dr Gallo is an Adjunct Professor both in the School of Public Health and in the Department of Pharmacology and Toxicology in the Ernest Mario School of Pharmacy of Rutgers University. He is a founding member of the Environmental and Occupational Health Sciences Institute where he served as Director of Toxicology, and as Director of the NIEHS Center of Excellence. He was the founding Director of the Cancer Institute of New Jersey and Associate Dean for Research. Dr. Gallo is a renowned toxicologist with expertise in the area of dioxins and PCBs, experimental models in pharmacology and toxicology, cytoplasmic and cell surface receptors, hormone biology and mechanisms of hormonal and environmental carcinogenesis. His avocation is History of Toxicology. Dr. Gallo served on several NIH committees including the ALTOX-4 Study Section, Chair of the Board of Scientific Councilors of the National Toxicology Program, and member of the NIEHS Board of Councilors. He also served as Chair of the NCI Centers Review committee, as well as a member of several NAS/NRC Expert committees including Drinking Water and Health; Pesticides in the Diets of Infants and Children; Risk Assessment Methodology; and the National Research Council/Institute of Medicine Roundtable on Environmental Health Sciences, Research and Medicine. He served the US-EPA as a member of the Scientific Advisory Board, and the Dioxin Review Science Advisory Board. Dr. Gallo was Chair of the New Jersey Governor’s Pesticide Control Council, and the New Jersey Cancer Risk Commission. Dr. Gallo serves as a consultant to the academic, government and private sectors.
Research Areas
Dioxins; Experimental Models; Pharmacology and Toxicology; Ocular Toxicity; Cytoplasmic Receptors; Hormones; Mechanisms of Carcinogenesis; Cell Surface Receptors; and Chemical Carcinogenesis
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Mechanisms of hepatotoxicity caused by lipopolysaccharide or acetaminophen, including cellular and molecular effects on isolated hepatocytes, liver macrophages and endothelial cells; characterization of subpopulations of liver macrophages and endothelial following toxicant injury; modulating the immune response to hepatotoxicants to modify liver injury by using knockout mice; and mechanisms of tissue repair following toxicant-induced injury.
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Dr. Georgopoulos is Professor of Environmental and Occupational Medicine at Rutgers University – Robert Wood Johnson Medical School. He is also a member of the Graduate Faculties of Chemical and Biochemical Engineering, Biomedical Engineering, and of Environmental Sciences at Rutgers University, and a member of the Rutgers Environmental and Occupational Health Sciences Institute (EOHSI). Dr. Georgopoulos received his M.S. and Ph.D. Degrees in Chemical Engineering from the California Institute of Technology (Caltech) and his Dipl. Ing. Degree from the National Technical University of Athens. At EOHSI he established and directs the Computational Chemodynamics Laboratory (CCL), a state-of-the-art facility for informatics and modeling of complex environmental and biological systems. Furthermore, he directs the State-funded Ozone Research Center and co-directs the Center for Exposure and Risk Modeling (CERM) at EOHSI. He is Co-Director of the Environmental Bioinformatics and Computational Toxicology Center (ebCTC), a research consortium of Rutgers University, Princeton University, and USFDA’s Center for Toxicoinformatics (funded by USEPA 2005-2010). He is also Director of the Informatics and Computational Toxicology Core for the NIEHS Center for Environmental Exposures and Disease (CEED) at EOHSI. He served as Director of the USDOE-funded Center of Expertise in Exposure Assessment of the Consortium for Risk Evaluation with Stakeholder Participation (CRESP). [read more…]
Research Interests
Multiscale Simulation of Environmental and Biological Systems and Interactions
Enviroinformatics and the Exposome
Risk Analysis for Environmental and Occupational Health
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My main area of research has focused on heavy metals exposure and effect. The current emphasis is on the relationship between mercury and selenium exposure and balancing the risks against benefits of fish consumption. Much of this work involves Native American and Alaskan Native communities.
A second area focuses on the environmental consequences of energy options, examining nuclear options in the light of the spent nuclear fuel impasse and the Fukushima disaster vs unintended consequences of renewable energy. This has been developed as an outgrowth of our CRESP work on hazardous waste, risk management, and land use decisions with the U.S. Department of Energy.
A third area focuses on incorporating workplace health and safety equity into the EPA’s “Environmental Justice” paradigm.
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Dr. Gordon received her BS in Chemistry (1973) and PhD. in the Rutgers-UMDNJ joint graduate program in Biochemistry in 1986. Dr. Gordon’s last year of graduate school was completed at Harvard Medical School in the Anatomy and Cell Biology Department, where she stayed to do post doctoral training. After a second post doctoral fellowship in the Anatomy and Cell Biology Department at Tufts Medical School she joined the faculty as an Assistant Professor, and remained there for 7 years. She came to the Ernest Mario School of Pharmacy in 1998, and is presently an Associate Professor in the Pharmacology and Toxicology Department.
Dr. Gordon has been continuously funded by NIH since 1988. She teaches the PharmD students in their P1 and P2 years in the Pathophysiology and in Pharmacology I and II courses. She has served on the thesis committees of 31 graduate students, and in her laboratory she has trained 2 MD research residents, 8 medical and graduate students (2 from Tufts Medical School), 13 pharmacy students (including 2 honors research students), as well as 1 MIT and 9 Rutgers undergraduate students. She has been thesis advisor to 1 M.S. student and 3 Ph.D. students in the Joint Program in Toxicology.
Dr. Gordon has served on the editorial boards for Developmental Dynamics, Anatomical Record, and on the editorial board of Matrix Biology. She currently serves on the Anterior Eye Disease Study Section of the NIH. She has been very active in the American Association of Anatomists, serving this national society as an executive officer for 5 years.
Research Areas
Dr. Gordon’s research examines corneal development and functional integrity as it relates to extracellular matrix. Projects involve the contribution of diverse collagens to corneal transparency, how they facilitate the attachment of epithelial and stromal cell layers, and what role the molecules play in wound healing. Dr. Gordon is also interested in collagen pathologies, especially fibrosis, in other organs. These investigations examine how Fibril-Associated Collagens with Interrupted Triple helices (FACITs) play a role in normal and pathological assembly of fibrils in the lung, liver, umbilical arteries and fetal membranes. The laboratory has also studied the roles of 3 transmembranous molecules, EMMPRIN, collagen XVII, and collagen XXIII, in development, wound healing, and cancer.
Research Highlights
Collagens, wound healing, fibrosis, corneal development, collagen pathologies, sulfur mustard injury, chemical counterterrorism
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Education
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Mechanisms of nitric oxide signaling in a wide variety of pathophysiological conditions; molecular mechanisms involved in controlling nitric oxide signaling and the role of nitric oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes; Nitric oxide in inflammatory cells such as macrophages and microglia.
Research
Our laboratory investigates mechanisms of Nitric Oxide signaling in a wide variety of pathophysiological conditions. We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism. In particular, we investigate the role of Nitric Oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes. We are particularly interested in the function of Nitric Oxide in inflammatory cells such as macrophages and microglia. It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted.
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Michael Greenberg studies environmental health and risk analysis. He is distinguished professor and associate dean of the faculty of the Edward J. Bloustein School of Planning and Public Policy, Rutgers University. He has written more than 30 books and more than 300 articles. His most recent books are The Environmental Impact Statement After Two Generations: Managing Environmental Power, New York: (Routledge 2011), Nuclear Waste Management, Nuclear Power and Energy Choices: Public Preferences, Perceptions, and Trust, (Springer 2012), and Protecting Seniors Against Environmental Disasters: From Hazards and Vulnerability to Prevention and Resilience (Earthscan 2014). He has been a member of National Research Council Committees that focus on the destruction of the U.S. chemical weapons stockpile and nuclear weapons; chemical waste management; and the degradation of the U.S. government physical infrastructure, and sustainability and the U.S. EPA. Currently, he is chairing a Committee for the appropriations committees of the U.S. Senate and House to determine the extent that the US DOE emphasizes human health and safety in its allocations for remediating former nuclear weapons sites. Dr. Greenberg has received awards from the United States Environmental Protection Agency, the Society for Professional Journalists, the Public Health Association, the Association of American Geographers, and Society for Risk Analysis. He served as area editor for social sciences and then editor-in-chief of Risk Analysis: An International Journal during the period 2002-2013, and continues as associate editor for environmental health for the American Journal of Public Health.
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Dr. Guo is an Associate Professor at the Department Pharmacology and Toxicology in the Ernest Mario School of Pharmacy of Rutgers University. She is an adjunct faculty of the Department of Pharmacology, Toxicology and Therapeutics in School of Medicine at the University of Kanas Medical Center. Dr. Guo obtained her MBBS degree from the West China University of Medical Sciences in 1993 and a PhD degree from the University of Kansas Medical Center in 2001, as well as post-doctoral training at the NCI, NIH in 2004. From 2004-2012, Dr. Guo has served as a faculty at the University of Kansas Medical Center.
Research Areas
Liver is essential for life and liver functions are tightly regulated. Particularly, the impact of intestine on liver homeostasis, function and diseases is significant, but this impact has been less studied. Our group has been focusing on determining the effects of intestine-liver crosstalks on liver metabolism and pathogenesis and the underlying molecular mechanisms, especially following disruption of endogenous homeostasis and exposure to xenobiotic chemicals.
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