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Photo of Michael A. Gallo Ph.D., D.A.B.T.
Michael A. Gallo, Ph.D., D.A.B.T.
Professor Emeritus Rutgers UniversityEOHSI – Toxicology

Dr. Gallo is a Professor in the Rutgers-Robert Wood Johnson Medical School Department of Environmental and Occupational Medicine. He is a Diplomate of the American Board of Toxicology, and a Fellow of the Academy of Toxicological Sciences. Dr Gallo is an Adjunct Professor both in the School of Public Health and in the Department of Pharmacology and Toxicology in the Ernest Mario School of Pharmacy of Rutgers University. He is a founding member of the Environmental and Occupational Health Sciences Institute where he served as Director of Toxicology, and as Director of the NIEHS Center of Excellence. He was the founding Director of the Cancer Institute of New Jersey and Associate Dean for Research. Dr. Gallo is a renowned toxicologist with expertise in the area of dioxins and PCBs, experimental models in pharmacology and toxicology, cytoplasmic and cell surface receptors, hormone biology and mechanisms of hormonal and environmental carcinogenesis. His avocation is History of Toxicology. Dr. Gallo served on several NIH committees including the ALTOX-4 Study Section, Chair of the Board of Scientific Councilors of the National Toxicology Program, and member of the NIEHS Board of Councilors. He also served as Chair of the NCI Centers Review committee, as well as a member of several NAS/NRC Expert committees including Drinking Water and Health; Pesticides in the Diets of Infants and Children; Risk Assessment Methodology; and the National Research Council/Institute of Medicine Roundtable on Environmental Health Sciences, Research and Medicine. He served the US-EPA as a member of the Scientific Advisory Board, and the Dioxin Review Science Advisory Board. Dr. Gallo was Chair of the New Jersey Governor’s Pesticide Control Council, and the New Jersey Cancer Risk Commission. Dr. Gallo serves as a consultant to the academic, government and private sectors.

Research Areas

Dioxins; Experimental Models; Pharmacology and Toxicology; Ocular Toxicity; Cytoplasmic Receptors; Hormones; Mechanisms of Carcinogenesis; Cell Surface Receptors; and Chemical Carcinogenesis

Scholarly Activities

  • 2011: Society of Toxicology Education Award
  • 2001: Chair, Hormonal Carcinogenesis Gordon Research Conference
  • 2000: Ambassador of Toxicology, Mid-Atlantic Society of Toxicology
  • 1985: Chair, Mechanisms of Toxicity Gordon Research Conference
  • 1985: UMDNJ Exceptional Merit Award
  • 1979: Russell Sage College Outstanding Alumni
  • 1971-1972: NIH Post Doctoral Fellow
  • 1968-1971 NIH Pre-Doctoral Fellow

Recent Publications

  1. Wesley, SR, Gallo, M, Apata, T, Dis, JV, Hollenbach, SJ. Impact of Endocrine-Disrupting Chemicals, Climate, and Air Pollution on Pregnancy Outcomes: A Scoping Review. Semin Reprod Med. 2024; :. doi: 10.1055/s-0044-1800961. PubMed PMID:39694048
  2. Novara, L, Antonioni, A, Vacca, L, Rosato, E, Lombardo, R, De Nunzio, C, Young Research Group of the Italian Society of Urodynamics. Letter to the Editor: How Useful are Current Chatbots Regarding Urology Patient Information? Comparison of the Ten Most Popular Chatbots’ Responses About Female Urinary Incontinence. J Med Syst. 2024;48 (1):111. doi: 10.1007/s10916-024-02131-6. PubMed PMID:39676073
  3. Cirronis, M, Giampreti, A, Eleftheriou, G, Gallo, M, Contessa, G, Faraoni, L, Butera, R, Bacis, G. Coma and confirmed epileptiform activity induced by Amanita pantherina poisoning. Toxicon. 2024;254 :108208. doi: 10.1016/j.toxicon.2024.108208. PubMed PMID:39662530
  4. Chen, MS, Liu, KC, Gallo, MC, Kusnezov, N, Chung, BC, Hwang, D, Christ, AB, Heckmann, ND. Characterizing the Rotational Profile of the Distal Femur: A Roadmap for Distal Femoral Replacement Surgery. J Am Acad Orthop Surg. 2024; :. doi: 10.5435/JAAOS-D-24-00207. PubMed PMID:39661775
  5. Gallo, L, Kim, P, Churchill, IF, Gallo, M, Yuan, M, Voineskos, SH, Thoma, A, Pusic, AL, Klassen, AF, Cano, SJ et al.. Measuring the Impact of Surgical and Non-surgical Facial Cosmetic Interventions Using FACE-Q Aesthetic Module Scales: A Systematic Review and Meta-Analysis. Plast Surg (Oakv). 2024; :22925503231225480. doi: 10.1177/22925503231225480. PubMed PMID:39553513 PubMed Central PMC11562317
  6. Kim, PJ, Gallo, L, Chen, J, Yuan, M, Gallo, M, Main, C, Coroneos, C. A 10-year Retrospective Review of Patient-to-Patient Transmitted Pathogens in Culture-Positive Burn Wounds at a Tertiary Burn Center. Plast Surg (Oakv). 2024; :22925503241249760. doi: 10.1177/22925503241249760. PubMed PMID:39553510 PubMed Central PMC11561929
  7. Milkovich, J, Churchill, IF, Gallo, L, Kim, P, Gallo, M, Thoma, A, Voineskos, SH, Main, C, Coroneos, CJ. The Impact of Surgical Wait Time and Hospital Stay on the Incidence of Burn Wound Infection and Related Complications at a Single Tertiary Hospital Centre: A 10-Year Experience. Plast Surg (Oakv). 2024; :22925503241249756. doi: 10.1177/22925503241249756. PubMed PMID:39553508 PubMed Central PMC11561922
  8. Semelak, JA, Gallo, M, González Flecha, FL, Di Pino, S, Pertinhez, TA, Zeida, A, Gout, I, Estrin, DA, Trujillo, M. Mg2+ binding to coenzyme A. Arch Biochem Biophys. 2025;763 :110202. doi: 10.1016/j.abb.2024.110202. PubMed PMID:39536960
  9. Gallo, M, Ferrari, E, Giovati, L, Pertinhez, TA, Artesani, L, Conti, S, Ciociola, T. The Variability of the Salivary Antimicrobial Peptide Profile: Impact of Lifestyle. Int J Mol Sci. 2024;25 (21):. doi: 10.3390/ijms252111501. PubMed PMID:39519054 PubMed Central PMC11547034
  10. NIHR Global Health Research Unit on Global Surgery, Kamarajah, SK, Alexander, P. Structures, processes and outcomes between first referral and referral hospitals in low-income and middle-income countries: a secondary preplanned analysis of the FALCON and ChEETAh randomised trials. BMJ Glob Health. 2024;9 (Suppl 4):. doi: 10.1136/bmjgh-2024-015599. PubMed PMID:39510564 PubMed Central PMC11552540
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Photo of Carol Gardner Ph.D.
Carol Gardner, Ph.D.
Associate Director, Flow Cytometry/Cell Sorting & Confocal Microscopy Core Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology

Research Areas

Mechanisms of hepatotoxicity caused by lipopolysaccharide or acetaminophen, including cellular and molecular effects on isolated hepatocytes, liver macrophages and endothelial cells; characterization of subpopulations of liver macrophages and endothelial following toxicant injury; modulating the immune response to hepatotoxicants to modify liver injury by using knockout mice; and mechanisms of tissue repair following toxicant-induced injury.

Research Highlights

  • Studies on polarization of liver macrophage and endothelial cell populations in rats and mice following acetaminophen intoxication.
  • Examination of drug interactions in mice treated with acetaminophen and an anthelminthic drug.
  • Effects of loss of caveolin on acetaminophen hepatotoxicity in mice.

Recent Publications

  1. Malaviya, R, Gardner, CR, Rancourt, RC, Smith, LC, Abramova, EV, Vayas, KN, Gow, AJ, Laskin, JD, Laskin, DL. Lung injury and oxidative stress induced by inhaled chlorine in mice is associated with proinflammatory activation of macrophages and altered bioenergetics. Toxicol Appl Pharmacol. 2023;461 :116388. doi: 10.1016/j.taap.2023.116388. PubMed PMID:36690086 PubMed Central PMC9960611
  2. Radbel, J, Meshanni, JA, Gardner, CR, Le-Hoang, O, Cervelli, J, Laskin, JD, Gow, AJ, Laskin, DL. Novel method to assess resident alveolar macrophage efferocytosis of apoptotic neutrophils by flow cytometry. Toxicol Appl Pharmacol. 2023;460 :116359. doi: 10.1016/j.taap.2022.116359. PubMed PMID:36565939 PubMed Central PMC9870943
  3. Torres, M, Carranza, C, Sarkar, S, Gonzalez, Y, Osornio Vargas, A, Black, K, Meng, Q, Quintana-Belmares, R, Hernandez, M, Angeles Garcia, JJF et al.. Urban airborne particle exposure impairs human lung and blood Mycobacterium tuberculosis immunity. Thorax. 2019;74 (7):675-683. doi: 10.1136/thoraxjnl-2018-212529. PubMed PMID:31036772 PubMed Central PMC7162557
  4. Chmielowski, RA, Abdelhamid, DS, Faig, JJ, Petersen, LK, Gardner, CR, Uhrich, KE, Joseph, LB, Moghe, PV. Athero-inflammatory nanotherapeutics: Ferulic acid-based poly(anhydride-ester) nanoparticles attenuate foam cell formation by regulating macrophage lipogenesis and reactive oxygen species generation. Acta Biomater. 2017;57 :85-94. doi: 10.1016/j.actbio.2017.05.029. PubMed PMID:28522412 PubMed Central PMC5546209
  5. Xu, D, Wang, H, Gardner, C, Pan, Z, Zhang, PL, Zhang, J, You, G. The role of Nedd4-1 WW domains in binding and regulating human organic anion transporter 1. Am J Physiol Renal Physiol. 2016;311 (2):F320-9. doi: 10.1152/ajprenal.00153.2016. PubMed PMID:27226107 PubMed Central PMC5243221
  6. Mandal, M, Gardner, CR, Sun, R, Choi, H, Lad, S, Mishin, V, Laskin, JD, Laskin, DL. The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury. Toxicol Appl Pharmacol. 2016;304 :110-20. doi: 10.1016/j.taap.2016.04.019. PubMed PMID:27163765 PubMed Central PMC5147741
  7. Jan, YH, Heck, DE, Dragomir, AC, Gardner, CR, Laskin, DL, Laskin, JD. Acetaminophen reactive intermediates target hepatic thioredoxin reductase. Chem Res Toxicol. 2014;27 (5):882-94. doi: 10.1021/tx5000443. PubMed PMID:24661219 PubMed Central PMC4033643
  8. Massa, CB, Scott, P, Abramova, E, Gardner, C, Laskin, DL, Gow, AJ. Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction. Toxicol Appl Pharmacol. 2014;278 (1):53-64. doi: 10.1016/j.taap.2014.02.006. PubMed PMID:24582687 PubMed Central PMC4361901
  9. Liu, Y, Gardner, CR, Laskin, JD, Laskin, DL. Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli. Exp Mol Pathol. 2013;94 (1):160-7. doi: 10.1016/j.yexmp.2012.10.015. PubMed PMID:23103612 PubMed Central PMC3562401
  10. Gardner, CR, Hankey, P, Mishin, V, Francis, M, Yu, S, Laskin, JD, Laskin, DL. Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase. Toxicol Appl Pharmacol. 2012;262 (2):139-48. doi: 10.1016/j.taap.2012.04.027. PubMed PMID:22575169 PubMed Central PMC3377817
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Photo of Panos Georgopoulos Ph.D.
Panos Georgopoulos, Ph.D.
Professor Rutgers University – School of Public HealthEOHSI – Environmental and Population Health Bio-Sciences

Dr. Georgopoulos is Professor of Environmental and Occupational Medicine at Rutgers University – Robert Wood Johnson Medical School. He is also a member of the Graduate Faculties of Chemical and Biochemical Engineering, Biomedical Engineering, and of Environmental Sciences at Rutgers University, and a member of the Rutgers Environmental and Occupational Health Sciences Institute (EOHSI). Dr. Georgopoulos received his M.S. and Ph.D. Degrees in Chemical Engineering from the California Institute of Technology (Caltech) and his Dipl. Ing. Degree from the National Technical University of Athens. At EOHSI he established and directs the Computational Chemodynamics Laboratory (CCL), a state-of-the-art facility for informatics and modeling of complex environmental and biological systems. Furthermore, he directs the State-funded Ozone Research Center and co-directs the Center for Exposure and Risk Modeling (CERM) at EOHSI. He is Co-Director of the Environmental Bioinformatics and Computational Toxicology Center (ebCTC), a research consortium of Rutgers University, Princeton University, and USFDA’s Center for Toxicoinformatics (funded by USEPA 2005-2010). He is also Director of the Informatics and Computational Toxicology Core for the NIEHS Center for Environmental Exposures and Disease (CEED) at EOHSI. He served as Director of the USDOE-funded Center of Expertise in Exposure Assessment of the Consortium for Risk Evaluation with Stakeholder Participation (CRESP). [read more…]

Research Interests

Multiscale Simulation of Environmental and Biological Systems and Interactions

  • Mathematical modeling of multimedia transport, fate and uptake of environmental pollutants – photochemical oxidants; air toxics; pesticides; solvents; heavy metals; nanomaterials; spores and pollens
  • Physiologically-based pharmacokinetics; inhalation, ingestion and dermal absorption dosimetry
  • Mechanistic pharmacodynamics
  • Virtual tissues
  • Computational systems toxicology and toxicogenomics

Enviroinformatics and the Exposome

  • Spatiotemporal data mining and analytics
  • Geographic Information and Database Management Systems
  • Multiroute/multipathway modeling of human exposures to chemical, radiological and biological agents
  • Climatic change impacts on environmental quality and human exposure and health
  • Environmental cheminformatics and bioinformatics

Risk Analysis for Environmental and Occupational Health

  • Uncertainty characterization and analysis
  • Diagnostic and prognostic risk assessment for exposures to carcinogens, neurotoxicants, allergens, irritants, endocrine disruptors
  • Individual and population based simulation modeling

Recent Publications

  1. Ren, X, Mi, Z, Georgopoulos, PG. Socioexposomics of COVID-19 across New Jersey: a comparison of geostatistical and machine learning approaches. J Expo Sci Environ Epidemiol. 2024;34 (2):197-207. doi: 10.1038/s41370-023-00518-0. PubMed PMID:36725924 PubMed Central PMC9889956
  2. Ren, X, Cai, T, Mi, Z, Bielory, L, Nolte, CG, Georgopoulos, PG. Modeling past and future spatiotemporal distributions of airborne allergenic pollen across the contiguous United States. Front Allergy. 2022;3 :959594. doi: 10.3389/falgy.2022.959594. PubMed PMID:36389037 PubMed Central PMC9640548
  3. Barrett, ES, Andrews, TR, Roy, J, Greenberg, P, Ferrante, JM, Horton, DB, Gordon, M, Rivera-Núñez, Z, Pellerano, MB, Tallia, AF et al.. Community- Versus Health Care Organization-Based Approaches to Expanding At-Home COVID-19 Testing in Black and Latino Communities, New Jersey, 2021. Am J Public Health. 2022;112 (S9):S918-S922. doi: 10.2105/AJPH.2022.306989. PubMed PMID:36265092 PubMed Central PMC9707722
  4. Ren, X, Mi, Z, Cai, T, Nolte, CG, Georgopoulos, PG. Flexible Bayesian Ensemble Machine Learning Framework for Predicting Local Ozone Concentrations. Environ Sci Technol. 2022;56 (7):3871-3883. doi: 10.1021/acs.est.1c04076. PubMed PMID:35312316 PubMed Central PMC9133919
  5. Ren, X, Weisel, CP, Georgopoulos, PG. Modeling Effects of Spatial Heterogeneities and Layered Exposure Interventions on the Spread of COVID-19 across New Jersey. Int J Environ Res Public Health. 2021;18 (22):. doi: 10.3390/ijerph182211950. PubMed PMID:34831706 PubMed Central PMC8618648
  6. Yu, CH, Weisel, CP, Alimokhtari, S, Georgopoulos, PG, Fan, ZT. Biomonitoring: A tool to assess PFNA body burdens and evaluate the effectiveness of drinking water intervention for communities in New Jersey. Int J Hyg Environ Health. 2021;235 :113757. doi: 10.1016/j.ijheh.2021.113757. PubMed PMID:33962122
  7. Zhang, X, Just, AC, Hsu, HL, Kloog, I, Woody, M, Mi, Z, Rush, J, Georgopoulos, P, Wright, RO, Stroustrup, A et al.. A hybrid approach to predict daily NO2 concentrations at city block scale. Sci Total Environ. 2021;761 :143279. doi: 10.1016/j.scitotenv.2020.143279. PubMed PMID:33162146
  8. Ren, X, Mi, Z, Georgopoulos, PG. Comparison of Machine Learning and Land Use Regression for fine scale spatiotemporal estimation of ambient air pollution: Modeling ozone concentrations across the contiguous United States. Environ Int. 2020;142 :105827. doi: 10.1016/j.envint.2020.105827. PubMed PMID:32593834
  9. Cai, T, Zhang, Y, Ren, X, Bielory, L, Mi, Z, Nolte, CG, Gao, Y, Leung, LR, Georgopoulos, PG. Development of a semi-mechanistic allergenic pollen emission model. Sci Total Environ. 2019;653 :947-957. doi: 10.1016/j.scitotenv.2018.10.243. PubMed PMID:30759620 PubMed Central PMC7841766
  10. Graber, JM, Alexander, C, Laumbach, RJ, Black, K, Strickland, PO, Georgopoulos, PG, Marshall, EG, Shendell, DG, Alderson, D, Mi, Z et al.. Per and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013-2014 NHANES. J Expo Sci Environ Epidemiol. 2019;29 (2):172-182. doi: 10.1038/s41370-018-0096-z. PubMed PMID:30482936 PubMed Central PMC6380951
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Photo of Michael Gochfeld M.D., Ph.D.
Michael Gochfeld, M.D., Ph.D.
Professor Emeritus Rutgers UniversityEOHSI – Clinical Research and Occupational Medicine

Research Areas

My main area of research has focused on heavy metals exposure and effect. The current emphasis is on the relationship between mercury and selenium exposure and balancing the risks against benefits of fish consumption. Much of this work involves Native American and Alaskan Native communities.

A second area focuses on the environmental consequences of energy options, examining nuclear options in the light of the spent nuclear fuel impasse and the Fukushima disaster vs unintended consequences of renewable energy. This has been developed as an outgrowth of our CRESP work on hazardous waste, risk management, and land use decisions with the U.S. Department of Energy.

A third area focuses on incorporating workplace health and safety equity into the EPA’s “Environmental Justice” paradigm.

Research Highlights

  • Participation in an EPA Environmental Justice Symposium resulted in exploration of the importance of outliers in risk management and the importance of occupational exposures as part of a comprehensive Environmental Justice paradigm.
  • The role of selenium in protecting against mercury toxicity has been known for 40 years, but the mechanism(s) of the interaction remain unclear. This study examines whether the Se:Hg molar ratio predicts mercury toxicity from fish consumption.

Scholarly Activities

  • Department of Environmental and Occupational Medicine: Chair of Curriculum Committee
  • Robert Wood Johnson Medical School: M1 Block Directors Committee
  • Special Committee on Health, Productivity, and Disability Management, American College of Occupational and Environmental Medicine.
  • Chair Committee on History of OSHA Permissible Exposure Limits

Recent Publications

  1. Passannante, MR, Shahani, S, Gochfeld, M, Purcell, WM, Savul, SA, Thomas, P. Teaching Climate and Health in Preventive Medicine Residency Programs: A Survey of Program Directors. J Grad Med Educ. 2024;16 (6 Suppl):120-124. doi: 10.4300/JGME-D-24-00348.1. PubMed PMID:39677910 PubMed Central PMC11644597
  2. Burger, J, Gochfeld, M, Brown, KG, Cortes, M, Ng, K, Kosson, D. Using the National Land Cover Database as an indicator of shrub-steppe habitat: comparing two large United States federal lands with surrounding regions. J Toxicol Environ Health A. 2025;88 (1):1-19. doi: 10.1080/15287394.2024.2412659. PubMed PMID:39396151
  3. Burger, J, Jeitner, C, Zappalorti, RT, Bunnell, JF, Ng, K, DeVito, E, Schneider, D, Gochfeld, M. Snake Fungal Disease in Free-Ranging Northern Pine Snakes (Pituophis melanoleucus melanoleucus) in New Jersey: Lesions, Severity of Sores and Investigator’s Perceptions. J Fungi (Basel). 2024;10 (2):. doi: 10.3390/jof10020125. PubMed PMID:38392797 PubMed Central PMC10889963
  4. Burger, J, Gochfeld, M, Brown, KG, Ng, K, Cortes, M, Kosson, D. The importance of recognizing Buffer Zones to lands being developed, restored, or remediated: on planning for protection of ecological resources. J Toxicol Environ Health A. 2024;87 (4):133-149. doi: 10.1080/15287394.2023.2285511. PubMed PMID:37997947 PubMed Central PMC10843829
  5. Burger, J, Feigin, S, Ng, K, Jeitner, C, Tsipoura, N, Niles, L, Gochfeld, M. Some metals and metalloids in the blood of three species of shorebirds increase while foraging during two-week migratory stopover in Delaware Bay, New Jersey. Environ Res. 2023;238 (Pt 2):117194. doi: 10.1016/j.envres.2023.117194. PubMed PMID:37748669 PubMed Central PMC10841762
  6. Burger, J, Gochfeld, M, Giffen, N, Brown, KG, Cortes, M, Ng, K, Kosson, DS. Comparing land cover and interior forests on contaminated land and the surrounding region: Oak Ridge Reservation as a case study. J Toxicol Environ Health A. 2023;86 (15):501-517. doi: 10.1080/15287394.2023.2223231. PubMed PMID:37335075
  7. Burger, J, Gochfeld, M, Zappalorti, R, Bunnell, J, Jeitner, C, Schneider, D, Ng, K, DeVito, E, Lorch, JM. Prevalence of Ophidiomyces ophidiicola and epizootiology of snake fungal disease in free-ranging Northern Pine Snakes (Pituophis melanoleucus melanoleucus) in New Jersey. Environ Monit Assess. 2023;195 (6):662. doi: 10.1007/s10661-023-11259-w. PubMed PMID:37169998
  8. Soskolne, CL, Kramer, S, Ramos-Bonilla, JP, Mandrioli, D, Sass, J, Gochfeld, M, Cranor, CF, Advani, S, Bero, LA. Correction: Toolkit for detecting misused epidemiological methods. Environ Health. 2022;21 (1):109. doi: 10.1186/s12940-022-00938-9. PubMed PMID:36368967 PubMed Central PMC9652904
  9. Soskolne, CL, Bero, LA, Kramer, S, Gochfeld, M, Ramos-Bonilla, JP, Sass, J, Cranor, CF, Advani, S, Mandrioli, D. Response to Toshihide Tsuda, Yumiko Miyano and Eiji Yamamoto [1]. Environ Health. 2022;21 (1):100. doi: 10.1186/s12940-022-00913-4. PubMed PMID:36284322 PubMed Central PMC9597996
  10. Gochfeld, M. Information needs, approaches, and case studies in human health risk communication. Risk Anal. 2022;42 (11):2376-2399. doi: 10.1111/risa.14006. PubMed PMID:36100396 PubMed Central PMC10087356
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Photo of Lawrence I Golbe M.D.
Lawrence I Golbe, M.D.
Professor Emeritus Rutgers UniversityNeurology- Clinical Academic Building

 

HOSPITAL AFFILIATIONS:
Robert Wood Johnson University Hospital – New Brunswick – New Brunswick, NJ
SPECIALTY:
Neurology – American Board of Psychiatry & Neurology
RESIDENCY:
Neurology, New York University – Bellevue Hospital, New York City, NY, US
Medicine, Hahnemann Hospital, Philadelphia, PA, US
INTERESTS:
Progressive supranuclear palsy (PSP), parkinsons disease, movement disorders
DEGREE:
New York University, New York, NY, US
Brown University, Providence, RI, US
Photo of Marion Gordon Ph.D.
Marion Gordon, Ph.D.
Associate Professor of Pharmacology and Toxicology Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology

Dr. Gordon received her BS in Chemistry (1973) and PhD. in the Rutgers-UMDNJ joint graduate program in Biochemistry in 1986. Dr. Gordon’s last year of graduate school was completed at Harvard Medical School in the Anatomy and Cell Biology Department, where she stayed to do post doctoral training. After a second post doctoral fellowship in the Anatomy and Cell Biology Department at Tufts Medical School she joined the faculty as an Assistant Professor, and remained there for 7 years. She came to the Ernest Mario School of Pharmacy in 1998, and is presently an Associate Professor in the Pharmacology and Toxicology Department.

Dr. Gordon has been continuously funded by NIH since 1988. She teaches the PharmD students in their P1 and P2 years in the Pathophysiology and in Pharmacology I and II courses. She has served on the thesis committees of 31 graduate students, and in her laboratory she has trained 2 MD research residents, 8 medical and graduate students (2 from Tufts Medical School), 13 pharmacy students (including 2 honors research students), as well as 1 MIT and 9 Rutgers undergraduate students. She has been thesis advisor to 1 M.S. student and 3 Ph.D. students in the Joint Program in Toxicology.

Dr. Gordon has served on the editorial boards for Developmental Dynamics, Anatomical Record, and on the editorial board of Matrix Biology. She currently serves on the Anterior Eye Disease Study Section of the NIH. She has been very active in the American Association of Anatomists, serving this national society as an executive officer for 5 years.

Research Areas

Dr. Gordon’s research examines corneal development and functional integrity as it relates to extracellular matrix. Projects involve the contribution of diverse collagens to corneal transparency, how they facilitate the attachment of epithelial and stromal cell layers, and what role the molecules play in wound healing. Dr. Gordon is also interested in collagen pathologies, especially fibrosis, in other organs. These investigations examine how Fibril-Associated Collagens with Interrupted Triple helices (FACITs) play a role in normal and pathological assembly of fibrils in the lung, liver, umbilical arteries and fetal membranes. The laboratory has also studied the roles of 3 transmembranous molecules, EMMPRIN, collagen XVII, and collagen XXIII, in development, wound healing, and cancer.

Research Highlights

Collagens, wound healing, fibrosis, corneal development, collagen pathologies, sulfur mustard injury, chemical counterterrorism

Scholarly Activities

  • 1988-1991: Individual National Research Service Award: “Avian Cornea Developmental Regulation of Collagens”
  • 1995: Invited to the laboratory of Dr. Ulla Wewer as an “Expert Guest Researcher” for collaborative research at the institute of Pathological Anatomy, University of Copenhagen, Denmark
  • 2000: Young Faculty Participation Award from the American Association of Anatomists
  • 2000- : Faculty for the National Eye Institute sponsored course “Fundamental Issues in Vision Research,” at the Marine Biological Laboratories, Woodshole, MA (Topic: “Corneal Extracellular Matrix”). The National Eye Institute has direct input into course topics, sponsors the course, financially supports the students, and has a representative present during the entire course.
  • 2000-2007: Co-director of the Signal Transduction Core of the NIEHS Center for Excellence at the Environmental and Occupational Health Sciences Institute
  • 2002: Program organizer for the “Matrix and Morphogenesis” conference, Boston, MA
  • 2004: appointed to the Editorial Board of Developmental Dynamics
  • 2004: appointed to the Board of Reviewers for Anatomical Record
  • 2004-2005: Member of the Federation of Societies for Experimental Biology (FASEB) Excellence in Science Award committee
  • 2004-2008: Elected to an executive position in a national society: Co-chair of the Program Committee of the American Association of Anatomists, a core member society of FASEB (the Federation of American Societies for Experimental Biology)
  • 2007-2009: Invited by the Douglass Residence Campus Dean Carmen Twillie Ambar to be on the Faculty Advisory Committee for the Douglass Project for Rutgers Women in Math, Science and Engineering
  • 2007- : Member of Advisory Cabinet for the “Fundamentals Issues in Vision Research” course, taught at the MBL in Woods Hole, MA
  • 2007- Faculty advisor for Pharmacy Profession Fraternity, Alpha Zeta Omega
  • 2008: Moderator for the American Association of Anatomists annual meeting Keynote Address by Harold f. Dvorak, MD, entitled “Angiogenesis: the Importance of Anatomy,” Experimental Biology 2008 meeting, San Diego, CA
  • 2008: Symposium chair for “Deciphering the Actions of Angiogenesis Inhibitors: Surprises and New Directions,” American Association of Anatomists, Experimental Biology 2008 meeting, San Diego, CA
  • 2008:  Moderator for the 36th Annual Scientific Session of the New Jersey Thoracic Society meeting
  • 2008: Special Guest Editor for Developmental Dynamics volume 237, issue 10, special issue entitled: Special Focus on the Extracellular Matrix, in Memory of Dr. Elizabeth D. Hay
  • 2008- : Co-director of the Diseases of the Integument Core, a unit of the NIEHS Center for Environmental Exposures and Disease
  • 2009: Moderator for the symposium entitled “Corneal Wound Healing and Cell Biology” at the annual Association for Research in Vision and Ophthalmology (ARVO) meeting
  • 2009-2013: NIH Center for Scientific Review regular standing study section member–Anterior Eye Disease

Recent Publications

  1. Joseph, LB, Gordon, MK, Zhou, P, Hahn, RA, Lababidi, H, Croutch, CR, Sinko, PJ, Heck, DE, Laskin, DL, Laskin, JD et al.. Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix. Exp Mol Pathol. 2022;128 :104807. doi: 10.1016/j.yexmp.2022.104807. PubMed PMID:35798063 PubMed Central PMC10044521
  2. Joseph, LB, Gordon, MK, Kang, J, Croutch, CR, Zhou, P, Heck, DE, Laskin, DL, Laskin, JD. Characterization of the rabbit conjunctiva: Effects of sulfur mustard. Exp Mol Pathol. 2021;121 :104656. doi: 10.1016/j.yexmp.2021.104656. PubMed PMID:34081961 PubMed Central PMC9006340
  3. DeSantis-Rodrigues, A, Hahn, RA, Zhou, P, Babin, M, Svoboda, KKH, Chang, YC, Gerecke, DR, Gordon, MK. SM1997 downregulates mustard-induced enzymes that disrupt corneal epithelial attachment. Anat Rec (Hoboken). 2021;304 (9):1974-1983. doi: 10.1002/ar.24597. PubMed PMID:33554453 PubMed Central PMC11236088
  4. Chang, YC, Hahn, RA, Gordon, MK, Laskin, JD, Gerecke, DR. A type IV collagenase inhibitor, N-hydroxy-3-phenyl-2-(4-phenylbenzenesulfonamido) propanamide (BiPS), suppresses skin injury induced by sulfur mustard. Toxicol Appl Pharmacol. 2020;401 :115078. doi: 10.1016/j.taap.2020.115078. PubMed PMID:32479919 PubMed Central PMC7470515
  5. Chang, YC, Wang, JD, Chang, HY, Zhou, P, Hahn, RA, Gordon, MK, Laskin, JD, Gerecke, DR. Expression of Laminin γ2 Proteolytic Fragments in Murine Skin Following Exposure to Sulfur Mustard. Anat Rec (Hoboken). 2020;303 (6):1642-1652. doi: 10.1002/ar.24405. PubMed PMID:32421930 PubMed Central PMC7394410
  6. Svoboda, KKH, Gordon, MK. Extracellular matrix: The proteins that function throughout the body. Anat Rec (Hoboken). 2020;303 (6):1509-1513. doi: 10.1002/ar.24404. PubMed PMID:32421924
  7. Eveleth, DD, Eveleth, JJ, Subramaniam, A, Hahn, R, Zhou, P, Gordon, MK, Bradshaw, RA. An Engineered Human Fibroblast Growth Factor-1 Derivative, TTHX1114, Ameliorates Short-term Corneal Nitrogen Mustard Injury in Rabbit Organ Cultures. Invest Ophthalmol Vis Sci. 2018;59 (11):4720-4730. doi: 10.1167/iovs.18-24568. PubMed PMID:30267094 PubMed Central PMC6155473
  8. Chang, YC, Gordon, MK, Gerecke, DR. Expression of Laminin 332 in Vesicant Skin Injury and Wound Repair. Clin Dermatol (Wilmington). 2018;2 (1):. . PubMed PMID:30058002 PubMed Central PMC6063082
  9. Chang, YC, Soriano, M, Hahn, RA, Casillas, RP, Gordon, MK, Laskin, JD, Gerecke, DR. Expression of cytokines and chemokines in mouse skin treated with sulfur mustard. Toxicol Appl Pharmacol. 2018;355 :52-59. doi: 10.1016/j.taap.2018.06.008. PubMed PMID:29935281 PubMed Central PMC6438172
  10. Gordon, MK, DeSantis-Rodrigues, A, Hahn, R, Zhou, P, Chang, Y, Svoboda, KK, Gerecke, DR. The molecules in the corneal basement membrane zone affected by mustard exposure suggest potential therapies. Ann N Y Acad Sci. 2016;1378 (1):158-165. doi: 10.1111/nyas.13226. PubMed PMID:27737494 PubMed Central PMC5221489
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Photo of Andrew Gow Ph.D.
Andrew Gow, Ph.D.
Professor Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology

Education

  • BSc,  (Hons)  University of Edinburgh, Edinburgh, Scotland, UK
  • MEd,  Temple University, Philadelphia, PA
  • PhD, Temple University, Philadelphia, PA
  • Post-Doc, University of Pennsylvania, Philadelphia, PA

Research Areas

Mechanisms of nitric oxide signaling in a wide variety of pathophysiological conditions; molecular mechanisms involved in controlling nitric oxide signaling and the role of nitric oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes; Nitric oxide in inflammatory cells such as macrophages and microglia.

Research

Our laboratory investigates mechanisms of Nitric Oxide signaling in a wide variety of pathophysiological conditions.  We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism.  In particular, we investigate the role of Nitric Oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes.  We are particularly interested in the function of Nitric Oxide in inflammatory cells such as macrophages and microglia.  It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted.

Research Highlights

  • S-nitrosylation of pulmonary collectins
  • Role of nitric oxide in lung disease
  • Mechanisms regulating nitric oxide biosynthesis

Scholarly Activities

  • 2001, Florence R.C. Murray Fellowship
  • 2000, Translational Medicine Award, Duke University
  • 1998, Chartered Chemist, Royal Society of Chemistry
  • 1997, Young Investigator Award, International Nitric Oxide Society
  • 1996, Young Investigator Award, Oxygen Society
  • 1995-97, National Research Service Award, National Institutes of Health-NHLBI in Lung Cell and Molecular Biology
  • 1993-95, Russell Conwell Research Fellowship

Recent Publications

  1. Lu, FT, Gupta, D, Fiedler, N, Satish, U, Black, KG, Legard, A, De Resende, A, Guo, C, Gow, AJ, Kipen, HM et al.. Mechanisms Underlying Acute Cognitive Impairment following Carbon Dioxide Inhalation in a Randomized Crossover Trial. Environ Health Perspect. 2024;132 (10):107702. doi: 10.1289/EHP14806. PubMed PMID:39466336 PubMed Central PMC11515854
  2. Aggarwal, T, Bellomo, A, Stevenson, ER, Herbert, J, Laskin, DL, Gow, AJ, Izgu, EC. Protocol for detecting nitrative stress in biological lipid membranes in murine cells and tissues. STAR Protoc. 2024;5 (3):103268. doi: 10.1016/j.xpro.2024.103268. PubMed PMID:39215997 PubMed Central PMC11403049
  3. Atochina-Vasserman, E, Meshanni, J, Stevenson, E, Zhang, D, Sun, R, Ona, N, Reagan, E, Abramova, E, Guo, CJ, Wilkinson, M et al.. Targeted delivery of TGF-β mRNA to lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers. Res Sq. 2024; :. doi: 10.21203/rs.3.rs-4656663/v1. PubMed PMID:39041040 PubMed Central PMC11261981
  4. Smith, LC, Abramova, E, Vayas, K, Rodriguez, J, Gelfand-Titiyevksiy, B, Roepke, TA, Laskin, JD, Gow, AJ, Laskin, DL. Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation. Toxicol Sci. 2024;201 (1):103-117. doi: 10.1093/toxsci/kfae081. PubMed PMID:38897669 PubMed Central PMC11347782
  5. Radbel, J, Meshanni, JA, Vayas, KN, Le-Hoang, O, Abramova, E, Zhou, P, Joseph, LB, Laskin, JD, Gow, AJ, Laskin, DL et al.. Effects of ozone exposure on lung injury, inflammation, and oxidative stress in a murine model of nonpneumonic endotoxemia. Toxicol Sci. 2024;200 (2):299-311. doi: 10.1093/toxsci/kfae062. PubMed PMID:38749002 PubMed Central PMC11285192
  6. Bellomo, A, Herbert, J, Kudlak, MJ, Laskin, JD, Gow, AJ, Laskin, DL. Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices. Toxicol Appl Pharmacol. 2024;486 :116941. doi: 10.1016/j.taap.2024.116941. PubMed PMID:38677601
  7. Malaviya, R, Meshanni, JA, Sunil, VR, Venosa, A, Guo, C, Abramova, EV, Vayas, KN, Jiang, C, Cervelli, JA, Gow, AJ et al.. Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard. Toxicol Appl Pharmacol. 2024;485 :116908. doi: 10.1016/j.taap.2024.116908. PubMed PMID:38513841
  8. Malin, SK, Remchak, ME, Heiston, EM, Battillo, DJ, Gow, AJ, Shah, AM, Liu, Z. Intermediate versus morning chronotype has lower vascular insulin sensitivity in adults with obesity. Diabetes Obes Metab. 2024;26 (5):1582-1592. doi: 10.1111/dom.15456. PubMed PMID:38246697 PubMed Central PMC11001524
  9. Gutierrez, B, Aggarwal, T, Erguven, H, Stone, MRL, Guo, C, Bellomo, A, Abramova, E, Stevenson, ER, Laskin, DL, Gow, AJ et al.. Direct assessment of nitrative stress in lipid environments: Applications of a designer lipid-based biosensor for peroxynitrite. iScience. 2023;26 (12):108567. doi: 10.1016/j.isci.2023.108567. PubMed PMID:38144454 PubMed Central PMC10746523
  10. Remchak, ME, Dosik, JK, Pappas, G, Gow, AJ, Shah, AM, Malin, SK. Exercise blood pressure and heart rate responses to graded exercise testing in intermediate versus morning chronotypes with obesity. Am J Physiol Heart Circ Physiol. 2023;325 (4):H635-H644. doi: 10.1152/ajpheart.00149.2023. PubMed PMID:37505468 PubMed Central PMC10642995
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Photo of Judith Graber Ph.D.
Judith Graber, Ph.D.
Associate Professor Rutgers University – School of Public HealthEOHSI – Environmental and Population Health Bio-Sciences

Research Areas

  • Cancer risk and risk factors among volunteer and career firefighters.
  • Adverse effects of occupational dust exposure and interactions with modifiable personal risk factors, including tobacco and alcohol use and obesity.
  • Per- and poly-fluoroalkyl substances (PFAS) exposure and health outcomes in occupational and community settings

 Research Highlights

  • Principal New Jersey Firefighters Cancer Prevention Project, looking at cancer risk among New Jersey volunteer and career firefighters. The long-term goal of this work is to reduce cancer incidence and mortality among firefighters.
  • Investigating the evaluate associations between health outcomes and multiple estimates of exposure to poly- and perfluoroalkyl substances (PFAS), with an emphasis on perfluorononanoic acid (PFNA), among members of highly exposed communities conditions, including work pace bullying and harassment,  and contribute to workplace and other injuries
  • Evaluating the contribution of World Trade Center related exposure to exposure to head neck cancer, given the etiologic role of tobacco use, heavy alcohol use and oral infection with the human papilloma virus in the incidence of cancer of the head and neck

Recent Publications

  1. Graber, JM, Alexander, C, Laumbach, RJ, Black, K, Strickland, PO, Georgopoulos, PG, Marshall, EG, Shendell, DG, Alderson, D, Mi, Z et al.. Per and polyfluoroalkyl substances (PFAS) blood levels after contamination of a community water supply and comparison with 2013-2014 NHANES. J Expo Sci Environ Epidemiol. 2019;29 (2):172-182. doi: 10.1038/s41370-018-0096-z. PubMed PMID:30482936 PubMed Central PMC6380951
  2. Bover Manderski, MT, Black, K, Udasin, IG, Giuliano, AR, Steinberg, MB, Ohman Strickland, P, Black, TM, Dasaro, CR, Crane, M, Harrison, D et al.. Risk factors for head and neck cancer in the World Trade Center Health Program General Responder Cohort: results from a nested case-control study. Occup Environ Med. 2019;76 (11):854-860. doi: 10.1136/oemed-2019-105890. PubMed PMID:31515248
  3. Casseus M, West B, Graber JM, Wackowski O, Cooney JM, JD; Lee HS. Disparities in disability status and illicit drug use among a nationally representative sample of U.S. College students. Disability and Health Journal [in press]Brackbill, RM, Graber, JM, Robison, WAA. Editorial for “Long-Term Health Effects of the 9/11 Disaster” in International Journal of Environmental Research and Public Health, 2019. Int J Environ Res Public Health. 2019;16 (18):. doi: 10.3390/ijerph16183289. PubMed PMID:31500226 PubMed Central PMC6765956
  4. Uhiara, D, Shendell, DG, Borjan, M, Graber, JM, Koshy, K, Lumia, M. Reported injury, hospitalization, and injury fatality rates among New Jersey adolescent workers. Inj Epidemiol. 2019;6 :37. doi: 10.1186/s40621-019-0216-9. PubMed PMID:31453047 PubMed Central PMC6699110
  5. Graber, JM, Harris, G, Black, K, Lucchini, RG, Giuliano, AR, Dasaro, CR, Shapiro, M, Steinberg, MB, Crane, MA, Moline, JM et al.. Excess HPV-related head and neck cancer in the world trade center health program general responder cohort. Int. J. Cancer. 2019;145 (6):1504-1509. doi: 10.1002/ijc.32070. PubMed PMID:30556136
  6. Wang, C, Bischoff, E, Eiden, AL, Zha, C, Cooper, R, Graber, JM. Residents Attitudes and Home Sanitation Predict Presence of German Cockroaches (Blattodea: Ectobiidae) in Apartments for Low-Income Senior Residents. J. Econ. Entomol. 2019;112 (1):284-289. doi: 10.1093/jee/toy307. PubMed PMID:30321349
  7. Graber, JM. Application of the Delphi method to reduce disability and mortality from coal mine dust lung disease in China; a new approach to an old problem. Occup Environ Med. 2018;75 (9):615-616. doi: 10.1136/oemed-2018-105075. PubMed PMID:29991498
  8. Graber, JM, Chuang, CT, Ward, CL, Black, K, Udasin, IG. Head and Neck Cancer in World Trade Center Responders: A Case Series. J. Occup. Environ. Med. 2018;60 (9):e439-e444. doi: 10.1097/JOM.0000000000001386. PubMed PMID:29933317 PubMed Central PMC6131053
  9. Shendell, DG, Graber, JM, Milich, LJ, Pratt, ME. Assessing Acute Symptoms Related to Occupational Exposures Among Nail Salon Technicians. J. Occup. Environ. Med. 2018;60 (4):343-349. doi: 10.1097/JOM.0000000000001210. PubMed PMID:29099468
  10. Farnacio, Y, Pratt, ME, Marshall, EG, Graber, JM. Are Workplace Psychosocial Factors Associated With Work-Related Injury in the US Workforce?: National Health Interview Survey, 2010. J. Occup. Environ. Med. 2017;59 (10):e164-e171. doi: 10.1097/JOM.0000000000001143. PubMed PMID:28991808

 

Photo of Michael R. Greenberg Ph.D.
Michael R. Greenberg, Ph.D.
Distinguished Professor and Associate Dean of the Faculty Rutgers University – Bloustein SchoolEOHSI – Environmental Health Policy

Michael Greenberg studies environmental health and risk analysis. He is distinguished professor and associate dean of the faculty of the Edward J. Bloustein School of Planning and Public Policy, Rutgers University. He has written more than 30 books and more than 300 articles. His most recent books are The Environmental Impact Statement After Two Generations: Managing Environmental Power, New York: (Routledge 2011), Nuclear Waste Management, Nuclear Power and Energy Choices: Public Preferences, Perceptions, and Trust, (Springer 2012), and Protecting Seniors Against Environmental Disasters: From Hazards and Vulnerability to Prevention and Resilience (Earthscan 2014). He has been a member of National Research Council Committees that focus on the destruction of the U.S. chemical weapons stockpile and nuclear weapons; chemical waste management; and the degradation of the U.S. government physical infrastructure, and sustainability and the U.S. EPA. Currently, he is chairing a Committee for the appropriations committees of the U.S. Senate and House to determine the extent that the US DOE emphasizes human health and safety in its allocations for remediating former nuclear weapons sites. Dr. Greenberg has received awards from the United States Environmental Protection Agency, the Society for Professional Journalists, the Public Health Association, the Association of American Geographers, and Society for Risk Analysis. He served as area editor for social sciences and then editor-in-chief of Risk Analysis: An International Journal during the period 2002-2013, and continues as associate editor for environmental health for the American Journal of Public Health.

Undergraduate Courses

  • Introduction to Planning, Public Policy, and Health

Graduate Courses

  • Environmental Planning and Management
  • Graduate Planning Studio
  • Transportation Risk & Security

Recent Publications

  1. Greenberg, MR, Schneider, D. Income disparities and risk: Geographical manifestations of extreme inequities in the United States. Risk Anal. 2024; :. doi: 10.1111/risa.14349. PubMed PMID:38984664
  2. Greenberg, MR, Lowrie, KW. Kenneth Olden: Whatever you do, do it well. Risk Anal. 2024;44 (9):1981-1990. doi: 10.1111/risa.14753. PubMed PMID:38955786
  3. Greenberg, MR, Lowrie, KW. John D. Graham: Making sense of risk. Risk Anal. 2024;44 (8):1735-1742. doi: 10.1111/risa.14350. PubMed PMID:38922745
  4. Greenberg, MR, Lowrie, K. Thomas Burke: Blending practice and academia at the highest levels. Risk Anal. 2023;43 (12):2405-2410. doi: 10.1111/risa.14225. PubMed PMID:38009438
  5. Greenberg, M, Lowrie, K. Robert Budnitz-Tinkerer, experimenter, and nuclear safety promoter. Risk Anal. 2024;44 (1):5-11. doi: 10.1111/risa.14246. PubMed PMID:38009429
  6. Greenberg, M, Lowrie, K. Kristin Shrader-Frechette: Confronting environmental injustice. Risk Anal. 2023; :. doi: 10.1111/risa.14174. PubMed PMID:37277917
  7. Greenberg, M, Schneider, D donas@rutgers.edu. Population density: What does it really mean in geographical health studies?. Health Place. 2023;81 :103001. doi: 10.1016/j.healthplace.2023.103001. PubMed PMID:36947902
  8. Greenberg, M, Lowrie, K, Heller, C, Kunreuther, L. Howard Kunreuther: An irrational economist committed to managing risk. Risk Anal. 2022;42 (12):2607-2612. doi: 10.1111/risa.14078. PubMed PMID:36717362
  9. Burger, J, Greenberg, M, Lowrie, K, Goldstein, BD. Bernard D. Goldstein-Risk communication as an essential component of public health practice. Risk Anal. 2022;42 (11):2459-2463. doi: 10.1111/risa.14055. PubMed PMID:36625059 PubMed Central PMC10316670
  10. Burger, J, Greenberg, M, Lowrie, K, Berlin, K. Ken Berlin-Climate science, risk, and solutions must be communicated together. Risk Anal. 2022;42 (11):2531-2535. doi: 10.1111/risa.14034. PubMed PMID:36625058 PubMed Central PMC10316665
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Abigail (Gail) Gregorio
Accounting Specialist Rutgers UniversityEOHSI – Central Administrattion
Photo of Grace L. Guo MBBS, Ph.D.
Grace L. Guo, MBBS, Ph.D.
Professor Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology

Biographical Info

Dr. Grace L. Guo is a Professor at the Department Pharmacology and Toxicology in the Ernest Mario School of Pharmacy of Rutgers University. Dr. Guo obtained her MBBS degree from the West China University of Medical Sciences in 1993 and a PhD degree in Toxicology from the University of Kansas Medical Center in 2001, as well as post-doctoral training at the NCI, NIH in 2004. From 2004-2012, Dr. Guo has been a faculty at the University of Kansas Medical Center.

Research Areas

The Guo lab focuses on the molecular mechanisms underlying intestine-liver crosstalk through nuclear receptor signaling pathways, which are pivotal for regulating bile acids, lipid homeostasis, and chemical disposition. A significant area of study is the bile acids-farnesoid X receptor (FXR)-fibroblast growth factor 15/19 (FGF15/19) axis, a critical regulator of hepatic functions and associated pathologies.

Dr. Guo and her research team have pioneered insights into the cellular and molecular mechanisms by which FXR operates in a tissue-specific manner to maintain bile acid homeostasis, particularly in the context of gut-liver interactions. Their work has implications for understanding and addressing non-alcoholic steatohepatitis (NASH), now called metabolic dysfunction-associated steatohepatitis (MASH), as well as the pathogenesis of liver and colon cancers and liver regeneration processes.

 

Dr. Guo’s research background is extensive, focusing on the functional characterization of bile acid signaling in hepatic diseases using animal models. Her expertise also covers lipid regulation, drug and toxin metabolism and transport, and their modulation by nuclear hormone receptors and cell signaling pathways. This comprehensive research contributes to a nuanced understanding of liver disease mechanisms and potential therapeutic avenues.

Scholarly Activities

2024                          ASPET Division of Toxicology Career Award

2023                          James R. Gillette Drug Metabolism and Disposition Best Paper of 2022 in the Drug Metabolism category, ASPET

2021                          Inaugural Presidential Outstanding Faculty Scholar Award, Rutgers University

2021                          Expertscape World Expert in Hepatocytes

2020                          Fellow of AASLD

Dr. Guo’s Google Scholar Citations

Recent Publications

  1. Yang, Z, Zarbl, H, Kong, B, Taylor, R, Black, K, Kipen, H, Basaly, V, Fang, M, Guo, GL. Liver-gut axis signaling regulates circadian energy metabolism in shift workers. FASEB J. 2024;38 (22):e70203. doi: 10.1096/fj.202402102R. PubMed PMID:39588921 PubMed Central PMC11590413
  2. Taylor, R, Basaly, V, Kong, B, Yang, I, Brinker, AM, Capece, G, Bhattacharya, A, Henry, ZR, Otersen, K, Yang, Z et al.. Effects of therapeutically approved individual bile acids on the development of metabolic dysfunction-associated steatohepatitis a low bile acid mouse model. Toxicol Sci. 2024;202 (2):179-195. doi: 10.1093/toxsci/kfae110. PubMed PMID:39302723
  3. Burchat, N, Vidola, J, Pfreundschuh, S, Sharma, P, Rizzolo, D, Guo, GL, Sampath, H. Intestinal Stearoyl-CoA Desaturase-1 Regulates Energy Balance via Alterations in Bile Acid Homeostasis. Cell Mol Gastroenterol Hepatol. 2024;18 (6):101403. doi: 10.1016/j.jcmgh.2024.101403. PubMed PMID:39278403 PubMed Central PMC11546130
  4. Jin, J, Nguyen, LTG, Wassef, A, Sadek, R, Schmitt, TM, Guo, GL, Rasmussen, TP, Zhong, XB. Correlations of Long Noncoding RNA HNF4A-AS1 Alternative Transcripts with Liver Diseases and Drug Metabolism. Drug Metab Dispos. 2024;52 (11):1345-1355. doi: 10.1124/dmd.124.001873. PubMed PMID:39168525
  5. Chow, MD, Otersen, K, Wassef, A, Kong, B, Yamarthy, S, Rizzolo, D, Yang, I, Buckley, B, Lu, A, Crook, N et al.. Effects of intestine-specific deletion of FGF15 on the development of fatty liver disease with vertical sleeve gastrectomy. Hepatol Commun. 2024;8 (6):. doi: 10.1097/HC9.0000000000000444. PubMed PMID:38780301 PubMed Central PMC11124683
  6. Jin, J, Nguyen, LTG, Wassef, A, Sadek, R, Schmitt, TM, Guo, GL, Rasmussen, TP, Zhong, XB. Identification and Functional Characterization of Alternative Transcripts of LncRNA HNF1A-AS1 and Their Impacts on Cell Growth, Differentiation, Liver Diseases, and in Response to Drug Induction. Noncoding RNA. 2024;10 (2):. doi: 10.3390/ncrna10020028. PubMed PMID:38668386 PubMed Central PMC11053763
  7. Taylor, R, Yang, Z, Henry, Z, Capece, G, Meadows, V, Otersen, K, Basaly, V, Bhattacharya, A, Mera, S, Zhou, P et al.. Characterization of individual bile acids in vivo utilizing a novel low bile acid mouse model. Toxicol Sci. 2024;199 (2):316-331. doi: 10.1093/toxsci/kfae029. PubMed PMID:38526215
  8. Yang, X, Wang, J, Chang, CY, Zhou, F, Liu, J, Xu, H, Ibrahim, M, Gomez, M, Guo, GL, Liu, H et al.. Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice. Nat Commun. 2024;15 (1):627. doi: 10.1038/s41467-024-44924-w. PubMed PMID:38245529 PubMed Central PMC10799847
  9. Yang, Z, Zarbl, H, Guo, GL. Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism. Mol Pharmacol. 2024;105 (3):179-193. doi: 10.1124/molpharm.123.000831. PubMed PMID:38238100 PubMed Central PMC10877735
  10. Bhattacharya, A, Taylor, RE, Guo, GL. In vivo mouse models to study bile acid synthesis and signaling. Hepatobiliary Pancreat Dis Int. 2023;22 (5):466-473. doi: 10.1016/j.hbpd.2023.08.009. PubMed PMID:37620226 PubMed Central PMC10790561
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