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Photo of Helmut Zarbl Ph.D.
Helmut Zarbl, Ph.D.
EOHSI Director – Professor – NIEHS Center Director Rutgers University- School of Public HealthEOHSI – Toxicology

Dr. Zarbl serves as the Director of the NIEHS sponsored Center for Environmental Exposures and Disease. He is also the Associate Director For Public Health Sciences at the Cancer Institute of New Jersey. He serves on numerous national research review and advisory panels, and editorial panels.. Dr. Zarbl is known for his work in areas of toxicogenomics, and mechanisms of and genetic susceptibility to chemical carcinogenesis, mechanisms of mutagenesis and toxicity, and technology development. These research efforts have to date resulted in over 70 scientific papers and book chapters.

Research Areas

Research has focused largely on toxicogenomics and functional genomics, carcinogenesis, molecular and cellular biology, and toxicology. Specifically this has included work understand to molecular mechanisms of chemical carcinogenesis and the genetic basis for differential susceptibility to mammary carcinogenesis using animal and in vitro model systems, and then translating the findings to human breast cancer.

Research Highlights

Studies in the rat model have included analysis of oncogene activation, mechanisms of signal transduction, and genetic linkage analysis to identify mammary tumor suppressor genes. He has also used toxicogenomics to dissect mechanisms of mechanism carcinogenesis, tumor progression and chemoprevention. His studies in the area of toxicogenomics include the development and application of standards for DNA microarray experiments, and phenotypic anchoring of response of human cells, model organisms (yeast) and target organs (rodents) to toxicants, providing insights into dose and temporal responses, as well as mechanisms of action. He is also actively involved in technology development for functional genomics and biomarker screening.

Recent Publications

  1. Yang, Z, Black, K, Ohman-Strickland, P, Graber, JM, Kipen, HM, Fang, M, Zarbl, H. Disruption of central and peripheral circadian clocks and circadian controlled estrogen receptor rhythms in night shift nurses in working environments. FASEB J. 2024;38 (11):e23719. doi: 10.1096/fj.202302261RR. PubMed PMID:38837828
  2. Yang, Z, DeLoid, GM, Baw, J, Zarbl, H, Demokritou, P. Assessment of Ingested Micro- and Nanoplastic (MNP)-Mediated Genotoxicity in an In Vitro Model of the Small Intestinal Epithelium (SIE). Nanomaterials (Basel). 2024;14 (9):. doi: 10.3390/nano14090807. PubMed PMID:38727401 PubMed Central PMC11085749
  3. Park, Y, Kang, HG, Kang, SJ, Ku, HO, Zarbl, H, Fang, MZ, Park, JH. Combined use of multiparametric high-content-screening and in vitro circadian reporter assays in neurotoxicity evaluation. Arch Toxicol. 2024;98 (5):1485-1498. doi: 10.1007/s00204-024-03686-6. PubMed PMID:38483585 PubMed Central PMC10965668
  4. Yang, Z, Zarbl, H, Guo, GL. Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism. Mol Pharmacol. 2024;105 (3):179-193. doi: 10.1124/molpharm.123.000831. PubMed PMID:38238100 PubMed Central PMC10877735
  5. Yang, Z, DeLoid, GM, Zarbl, H, Baw, J, Demokritou, P. Micro- and nanoplastics (MNPs) and their potential toxicological outcomes: State of science, knowledge gaps and research needs. NanoImpact. 2023;32 :100481. doi: 10.1016/j.impact.2023.100481. PubMed PMID:37717636 PubMed Central PMC10841092
  6. Venosa, A, Smith, LC, Gow, AJ, Zarbl, H, Laskin, JD, Laskin, DL. Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression. Toxicol Appl Pharmacol. 2021;423 :115569. doi: 10.1016/j.taap.2021.115569. PubMed PMID:33971176 PubMed Central PMC8496734
  7. Liu, Y, Chen, X, Gong, Z, Zhang, H, Fei, F, Tang, X, Wang, J, Xu, P, Zarbl, H, Ren, X et al.. Fry Is Required for Mammary Gland Development During Pregnant Periods and Affects the Morphology and Growth of Breast Cancer Cells. Front Oncol. 2019;9 :1279. doi: 10.3389/fonc.2019.01279. PubMed PMID:31824855 PubMed Central PMC6881260
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Chuang (Charlie) Zhao
Rutgers UniversityEOHSI – Central Administration
Liping Zhao, Ph.D.
Professor Rutgers UniversitySchool of Environmental and Biological Sciences- Department Biochemistry and Microbiology
Photo of Wenlong Zhao Ph.D.
Wenlong Zhao, Ph.D.
Post-Doctoral Associate Rutgers – Ernest Mario School of PharmacyEOHSI – Toxicology Division
Peihong Zhou, MS
Rutgers UniversityEOHSI – Toxicology
Photo of Dr. Renping Zhou Ph.D.
Dr. Renping Zhou, Ph.D.
Professor Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology

Research Areas

The Zhou laboratory is interested in the mechanisms mediating cell-cell communication and their roles in normal development, physiology, and diseases. Specifically the Zhou laboratory is investigating the functions of a large family of tyrosine kinase receptors, the Ephs, and their ligands, the ephrins, in neural circuit formation, eye development, and behavior regulations including motor activity, circadian rhythm, and aggression. The Zhou laboratory employs both in vitro and in vivo techniques, including neuron cultures, transgenic and knockout mice, as well as behavior assays.

Research Highlights

Demonstration of a repulsive function of ephrins in axon guidance

Discovering signal transduction pathways mediating ephrin-induced growth cone guidance

Establishing a novel cataract mouse model

Elucidating regulation of cell-cell adhesion by ephrins

Scholarly Activities

Member of editorial board: Neuroscience Bulletin; Cell & Bioscience

Membership in: AAAS, Society of Neuroscice, ARVO

Recent Publications

  1. Zhou, RZ, Wimo, A, Winblad, B. Editorial: On the 2024 Alzheimer’s Association Criteria: Still Not Ready for Clinical Use. J Prev Alzheimers Dis. 2024;11 (4):895-896. doi: 10.14283/jpad.2024.141. PubMed PMID:39044499
  2. Zhang, L, Li, G, Lin, B, He, H, Zhou, R, Jiang, W. Corrigendum to “Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome” [Int. Immunopharmacol. 131 (2024) 111915]. Int Immunopharmacol. 2024; :112726. doi: 10.1016/j.intimp.2024.112726. PubMed PMID:39043482
  3. Zhou, H, Cao, Y, Khmelevskyi, S, Zhang, Q, Hu, S, Avdeev, M, Wang, CW, Zhou, R, Yu, C, Chen, X et al.. Colossal Zero-Field-Cooled Exchange Bias via Tuning Compensated Ferrimagnetic in Kagome Metals. J Am Chem Soc. 2024; :. doi: 10.1021/jacs.4c04173. PubMed PMID:39039443
  4. Ren, C, Wang, F, Meng, X, Zhou, R, Sun, Z, Cheng, Y, Chu, H, Wang, Y. Supramolecular Modulator Assisted Cryo-Engineered Porous Cu-DNA Nano-Vehicles for Versatile Theranostic Agent Delivery. Adv Healthc Mater. 2024; :e2401885. doi: 10.1002/adhm.202401885. PubMed PMID:39036819
  5. Li, X, Du, X, He, Z, Zhou, R, Guo, Y, Liu, J, Lian, J, Guo, X, Tang, Z. Transcriptome mechanisms of dandelion under stress of polystyrene and dibutyl phthalate and quantitative tracing of nanoplastics. Sci Total Environ. 2024; :174894. doi: 10.1016/j.scitotenv.2024.174894. PubMed PMID:39034002
  6. Sheen, JZ, Mazza, F, Momi, D, Miron, JP, Mansouri, F, Russell, T, Zhou, R, Hyde, M, Fox, L, Voetterl, H et al.. N100 as a response prediction biomarker for accelerated 1 Hz right DLPFC-rTMS in major depression. J Affect Disord. 2024; :. doi: 10.1016/j.jad.2024.07.131. PubMed PMID:39033822
  7. Qiu, CZ, Zhou, R, Zhang, HY, Zhang, L, Yin, ZJ, Ren, DL. Histone lactylation-ROS loop contributes to light exposure-exacerbated neutrophil recruitment in zebrafish. Commun Biol. 2024;7 (1):887. doi: 10.1038/s42003-024-06543-5. PubMed PMID:39033200
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Hao Zhu, Ph.D.
Associate Professor Rutgers UniversityCenter for Computational and Integrative Biology – FASC
Photo of Wei-Xing Zong Ph.D.
Wei-Xing Zong, Ph.D.
Professor and Co-Leader, John L. Colaizzi Chair in Pharmacy Rutgers UniversitySusan Lehman Cullman Laboratory for Cancer Research

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