Biographical Info

Research Areas

The Zhou laboratory is interested in the mechanisms mediating cell-cell communication and their roles in normal development, physiology, and diseases. Specifically the Zhou laboratory is investigating the functions of a large family of tyrosine kinase receptors, the Ephs, and their ligands, the ephrins, in neural circuit formation, eye development, and behavior regulations including motor activity, circadian rhythm, and aggression. The Zhou laboratory employs both in vitro and in vivo techniques, including neuron cultures, transgenic and knockout mice, as well as behavior assays.

Research Highlights

Demonstration of a repulsive function of ephrins in axon guidance

Discovering signal transduction pathways mediating ephrin-induced growth cone guidance

Establishing a novel cataract mouse model

Elucidating regulation of cell-cell adhesion by ephrins

Scholarly Activities

Member of editorial board: Neuroscience Bulletin; Cell & Bioscience

Membership in: AAAS, Society of Neuroscice, ARVO

Recent Publications

1. Hao, W, Zhu, R, Zhang, H, Chen, Y, Li, S, Zhou, F, Hu, W, Zhou, R. NS8593 inhibits chondrocyte ferroptosis and alleviates cartilage injury in rat adjuvant arthritis through TRPM7 / HO-1 pathway. Int J Biochem Cell Biol. 2024; :106618. doi: 10.1016/j.biocel.2024.106618. PubMed PMID:39053766
2. Lian, CL, Chen, GP, Zhou, R, Yu, YF, Zhou, P, Lin, Q, Wu, SG. Efficacy of thyroid hormone replacement therapy in nasopharyngeal carcinoma patients with radiation-induced subclinical hypothyroidism. Exp Clin Endocrinol Diabetes. 2024; :. doi: 10.1055/a-2373-0030. PubMed PMID:39053589
3. Zhou, R, Zhe, L, Lai, SS, Wen, HM, Hu, L, Zhang, XL, Zhuo, Y, Xu, SY, Lin, Y, Feng, B et al.. Dietary sodium sulphate supplementation during mid-to-late gestation improves placental angiogenesis, bile acid metabolism, and serum amino acid concentrations of sows. Animal. 2024;18 (8):101237. doi: 10.1016/j.animal.2024.101237. PubMed PMID:39053158
4. Zhou, R, Jia, X, Li, Z, Huang, S, Feng, W, Zhu, X. Identifying an immunosenescence-associated gene signature in gastric cancer by integrating bulk and single-cell sequencing data. Sci Rep. 2024;14 (1):17055. doi: 10.1038/s41598-024-68054-x. PubMed PMID:39048596
5. Zhou, RZ, Wimo, A, Winblad, B. Editorial: On the 2024 Alzheimer’s Association Criteria: Still Not Ready for Clinical Use. J Prev Alzheimers Dis. 2024;11 (4):895-896. doi: 10.14283/jpad.2024.141. PubMed PMID:39044499
6. Zhang, L, Li, G, Lin, B, He, H, Zhou, R, Jiang, W. Corrigendum to “Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome” [Int. Immunopharmacol. 131 (2024) 111915]. Int Immunopharmacol. 2024; :112726. doi: 10.1016/j.intimp.2024.112726. PubMed PMID:39043482
7. Zhou, H, Cao, Y, Khmelevskyi, S, Zhang, Q, Hu, S, Avdeev, M, Wang, CW, Zhou, R, Yu, C, Chen, X et al.. Colossal Zero-Field-Cooled Exchange Bias via Tuning Compensated Ferrimagnetic in Kagome Metals. J Am Chem Soc. 2024; :. doi: 10.1021/jacs.4c04173. PubMed PMID:39039443