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Photo of Shuo Xiao Ph.D.
Shuo Xiao, Ph.D.
Assistant Professor – Department of Pharmacology and Toxicology Rutgers University – Ernest Mario School of PharmacyEOHSI- Toxicology

Biographical Info

Dr. Xiao is an Assistant Professor from the Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy at Rutgers University. He received his BMed in Preventive Medicine and MS in Toxicology from Peking University Health Science Center and obtained his PhD in Reproductive Biology and Toxicology from Dr. Xiaoqin Ye’s lab at the University of Georgia (UGA). Dr. Xiao completed his postdoctoral fellowship in Dr. Teresa Woodruff’s lab at Northwestern University Department of Obstetrics and Gynecology. Dr. Xiao started his faculty appointment in 2017 at University of South Carolina School of Public Health Department of Environmental Health Sciences. In 2020, Dr. Xiao moved his lab to Rutgers University.

Research Areas

Dr. Xiao’s research is primarily focused on female reproductive biology, disease, and toxicology, including (1) adverse effects of emerging environmental contaminants on women’s reproductive health, in particular of ovarian functions, menstrual cycle, and fertility; (2) engineering female reproductive system using microfluidic and organ-on-a-chip technologies; (3) developing novel non-hormonal female contraceptives; and (4) environmental exposure on women’s reproductive diseases such as polycystic ovarian syndrome (PCOS). Dr. Xiao’s research is supported by NIH (R01ES032144), Department of Defense (DOD, TX220205), Bill & Melinda Gates Foundation (INV-003385), Health and Environmental Sciences Institute (HESI), and New Jersey Department of Environmental Protection (NJDEP), and Rutgers Office for Research and EOHSI.

Research Highlights

  • Ovarian disrupting effects of classic and emerging environmental contaminants
  • Mechanism of cancer treatment-induced premature ovarian failure and infertility in young female cancer patients
  • Fertility preservation for young female cancer patients
  • Engineering female reproductive system on a chip
  • Development of novel non-hormonal contraceptive for women

Scholarly Activities and Recent Awards

  • Co-Chair of Basic Science Committee, Oncofertility Consortium
  • Editorial Board: Reproductive Toxicology, Biology of Reproduction, and Endocrinology,
  • Teaching and Laboratory Faculty, Frontiers in Reproduction (FIR), Marine Biology Laboratory (MBL), Woods Hole, MA
  • American Society for Pharmacology and Experimental Therapeutics (ASPET) Toxicology Division Early Career Award, 2024
  • JOINN Biomere Outstanding Young Toxicologist Award of American Association of Chinese in Toxicology (AACT), 2023
  • Chancellor Basic Sciences Researcher Award, Rutgers Biomedical and Health Sciences (RBHS), Rutgers University, 2022
  • New-Career Scientist Award, Reproductive and Developmental Toxicology Specialty Section (RDTSS), Society of Toxicology (SOT), 2022
  • The Rising Stars in Reproductive Biology Webinar Series. Society for the Study of Reproduction (SSR), 2022
  • Best Publication in Toxicological Sciences, Reproductive and Developmental Toxicology Specialty Section (RDTSS), Society of Toxicology (SOT) Annual Meeting, 2021

Recent publications (*as the corresponding author)

  1. Wang Y, Pattarawat P, Zhang J, Kim E, Zhang D, Fang M, Jannaman EA, Yuan Y, Chatterjee S, Kim JJ, Scott GI, Zhang Q, Xiao S*. Cyanobacterial harmful algal bloom toxin microcystin-LR interferes with gonadotropin-dependent ovarian follicle maturation and ovulation. Environmental Health Perspectives (EHP). 2023 Jun;131(6):67010. PMID: 37342990. (NIEHS Papers of the Month in September 2023)
  2. Zhang J, Russo DD, Wang Y, Zhang Q, Zelinski MB, Shalet AK, Goods BA, Xiao S*. Vitrification preserves follicular transcriptomic dynamics during ex vivo ovulation. Biology of Reproduction (BOR). 2023 Sep 12;109(3):240-243.PMID: 37498173.
  3. McClam M, Liu J, Fan Yi, Zhang T, Zhang WQ, Porter DE, Scott GI, Xiao S*. Associations between exposure to single cadmium, lead, mercury and mixtures and women’s infertility and long-term amenorrhea. Achieves of Public Health. 2023; 81: 161. PMID: 37626539.
  4. Zhang J, Goods BA, Pattarawat P, Wang Y, Haining T, Zhang Q, Shalek AK, Duncan FE, Woodruff TK, Xiao S*. An ex vivo ovulation system enables the discovery of novel ovulatory pathways and non-hormonal contraceptive candidates. Biology of Reproduction (BOR). 2023 Apr 11;108(4):629-644.
  5. Wang Y, Russo DD, Pattarawat P, Zhang Q, Zelinski MB, Shalek AK, Goods BA, Xiao S*. Vitrification preserves murine ovarian follicular cell transcriptome in a 3D encapsulated in vitro follicle growth system. Biology of Reproduction (BOR). 2021.
  6. Jiang K, Zhang J, Huang Y, Wang Y, Xiao S, Hadden MK, Woodruff TK, Sun J. A platform utilizing Drosophila ovulation for nonhormonal contraceptive screening. Proceedings of the National Academy of Sciences(PNAS). 2021.
  7. Xu J, Wang Y, Kauffman AE, Zhang Y, Li Y, Zhu J, Maratea K, Fabre K, Zhang Q, Woodruff TK, Xiao S*. A tiered female ovarian toxicity screening identifies toxic effects of checkpoint 2 kinase 1 inhibitors on murine growing follicles. Toxicological Sciences. 2020.
  8. Zubizarreta ME, and Xiao S*. Bioengineering models of female reproduction. Bio-Design and Manufacturing. 2020.
  9. Jiang B, Kauffman AE, Li L, McFee W, Cai B, Weinstein J, Lead J, Chatterjee S, Scott GI, Xiao S*. Health impacts of environmental contamination of micro- and nanoplastics: a review. Environmental Health and Preventive Medicine. 2020.
  10. Wang Y, Xu J, Stanley J. Xu M, Brooks BW, Scott GI, Chatterjee S. Zhang Q, Zelinski MB, Xiao S*. A closed vitrification system enables a murine ovarian follicle bank for high-throughput ovotoxicity screening, which identifies the endocrine disrupting activity of microcystins. Reproductive Toxicology. 2020.
  11. Sarkar S, Alhasson F, Kimono D, Albadrani M, Seth RK, Xiao S, Porter DE, Scott GI,
  12. Wang Y, Liu M, Johnson SB, Yuan G, Arriba AK, Zubizarreta ME, Chatterjee S, Nagarkatti M, Nagarkatti P, Xiao S*. Doxorubicin obliterates mouse ovarian reserve through both primordial follicle atresia and overactivation. Toxicology and Applied Pharmacology. 2019.
  13. Andersen CL, Liu M, Wang Z, Ye X*, Xiao S*. Chemotherapeutic agent doxorubicin alters uterine gene expression in response to estrogen in ovariectomized CD-1 adult mice. Biology of Reproduction. 2019.
  14. Wang Y, Chen H, Ju K, Kopp MF, Johnson SB, Farrell KK, Yuan G, Ataman LM, Zheng W, Woodruff TK, Xiao S*. Female oncofertility attitude and knowledge: a survey of reproductive health professionals in Shanghai, China. Future Oncology.
  15. Ju K, Kopp M, Wang Y, Yuan G, Zheng W, Ataman LM, Woodruff TK, Chen Q, Xiao S*. A Survey Study of Attitude and Knowledge Regarding Female Fertility Preservation Among Reproductive Health Professionals in Fujian, China. Journal of Adolescent Young Adult Oncology. 2019.
  16. Wang Y, Liu M, Zhang, J, Liu Y, Kopp M, Zheng W, Xiao S*. Multidrug resistance protein 1 deficiency promotes doxorubicin-induced ovarian toxicity in female mice. Toxicological Sciences. 2018 (Cover image).
  17. Xiao S, Coppeta JR, Rogers HB, Isenberg BC, Zhu J, Olalekan SA, McKinnon KE, Dokic D, Rashedi AS, Haisenleder DJ, Malpani SS, Arnold-Murray CA, Chen K, Jiang M, Bai L, Nguyen CT, Zhang J, Laronda MM, Hope TJ, Maniar KP, Pavone ME, Avram MJ, Sefton EC, Getsios S, Burdette JE, Kim JJ, Borenstein JT, Woodruff TK. A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. Nature Communications. 2017 (NIEHS 2017 Papers of the Year).
  18. Laronda MM, Rutz AL, Xiao S, Whelan KA, Duncan FE, Roth EW, Woodruff TK, Shah RN. A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice. Nature Communications. 2017.
  19. Xiao S*, Zhang J, Liu M, Iwahata H, Rogers HB, Woodruff TK. Doxorubicin Has Dose-Dependent Toxicity on Mouse Ovarian Follicle Development, Hormone Secretion, and Oocyte Maturation. Toxicological Sciences. 2017.
  20. Xiao S, Li R, El Zowalaty A, Diao H, Zhao F, Choi Y and Ye X. Acidification of uterine epithelium during embryo implantation in mice. Biology of Reproduction. 2017.
  21. Xiao S, Zhang J, Romero MM, Smith KN, Shea LD, Woodruff TK. In vitro follicle growth supports human oocyte meiotic maturation. Scientific Reports. 2015.
  22. Xiao S, Duncan FE, Bai L, Nguyen, CT, Shea LD, Woodruff TK. Size-specific follicle selection improves mouse oocyte reproductive outcomes. Reproduction,

The full publication list is available at: https://www.ncbi.nlm.nih.gov/myncbi/shuo.xiao.1/bibliography/public/

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