Grace L. Guo, MBBS, Ph.D.

Professor Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology
Work EOHSI Room 322 170 Frelinghuysen Rd Piscataway NJ 08854 Work Phone: 848-445-8186 (office) Work Phone: 848-445-6102 (Lab) Work Fax: 732-445-4161
Photo of Grace L. Guo MBBS, Ph.D.

Biographical Info

Dr. Guo is an Associate Professor at the Department Pharmacology and Toxicology in the Ernest Mario School of Pharmacy of Rutgers University. She is an adjunct faculty of the Department of Pharmacology, Toxicology and Therapeutics in School of Medicine at the University of Kanas Medical Center.  Dr. Guo obtained her MBBS degree from the West China University of Medical Sciences in 1993 and a PhD degree from the University of Kansas Medical Center in 2001, as well as post-doctoral training at the NCI, NIH in 2004. From 2004-2012, Dr. Guo has served as a faculty at the University of Kansas Medical Center.

Research Areas

Liver is essential for life and liver functions are tightly regulated. Particularly, the impact of intestine on liver homeostasis, function and diseases is significant, but this impact has been less studied. Our group has been focusing on determining the effects of intestine-liver crosstalks on liver metabolism and pathogenesis and the underlying molecular mechanisms, especially following disruption of endogenous homeostasis and exposure to xenobiotic chemicals.

Scholarly Activities

  • 2012: Presidential Poster Award, AASLD meeting (2)
  • 2011: Presidential Poster Award, AASLD meeting
  • 2010: Presidential Poster Award, AASLD meeting
  • 2009: Presidential Poster Award, AASLD meeting
  • 2009: Post award winner for Annual Liver Center Symposium, University of Kansas Medical Center
  • 2007: First place in oral presentation in Annual Cancer Center Symposium, University of Kansas Medical Center
  • 2005: BIRCWH/NIH scholar

Recent Publications

  1. Rizzolo, D, Kong, B, Taylor, RE, Brinker, A, Goedken, M, Buckley, B, Guo, GL. Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1. Acta Pharm Sin B. 2021;11 (12):3847-3856. doi: 10.1016/j.apsb.2021.05.023. PubMed PMID:35024311 PubMed Central PMC8727763
  2. Rizzolo, D, Kong, B, Piekos, S, Chen, L, Zhong, XB, Lu, J, Shi, J, Zhu, HJ, Yang, Q, Li, AP et al.. Effects of Overexpression of Fibroblast Growth Factor 15/19 on Hepatic Drug Metabolizing Enzymes. Drug Metab Dispos. 2021; :. doi: 10.1124/dmd.121.000416. PubMed PMID:34965924
  3. Thangamani, S, Monasky, R, Lee, JK, Antharam, V, HogenEsch, H, Hazbun, TR, Jin, Y, Gu, H, Guo, GL. Bile Acid Regulates the Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract by Controlling Host Defense System and Microbiota. J Fungi (Basel). 2021;7 (12):. doi: 10.3390/jof7121030. PubMed PMID:34947012 PubMed Central PMC8708873
  4. Taylor, RE, Bhattacharya, A, Guo, GL. Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling. Drug Metab Dispos. 2021; :. doi: 10.1124/dmd.121.000388. PubMed PMID:34759011
  5. Wang, H, Brown, PC, Chow, ECY, Ewart, L, Ferguson, SS, Fitzpatrick, S, Freedman, BS, Guo, GL, Hedrich, W, Heyward, S et al.. 3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration. Clin Transl Sci. 2021;14 (5):1659-1680. doi: 10.1111/cts.13066. PubMed PMID:33982436 PubMed Central PMC8504835
  6. Wang, F, Zhang, Y, Shen, J, Yang, B, Dai, W, Yan, J, Maimouni, S, Daguplo, HQ, Coppola, S, Gao, Y et al.. The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway. Cell Mol Gastroenterol Hepatol. 2021;11 (5):1369-1385. doi: 10.1016/j.jcmgh.2021.01.007. PubMed PMID:33482392 PubMed Central PMC8024979
  7. Sun, R, Kong, B, Yang, N, Cao, B, Feng, D, Yu, X, Ge, C, Feng, S, Fei, F, Huang, J et al.. The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal Farnesoid X Receptor Signaling Pathway and Inhibition of Hepatic Gluconeogenesis. Drug Metab Dispos. 2021;49 (3):276-286. doi: 10.1124/dmd.120.000215. PubMed PMID:33376148
  8. Kim, YC, Seok, S, Zhang, Y, Ma, J, Kong, B, Guo, G, Kemper, B, Kemper, JK. Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A. Nat Commun. 2020;11 (1):5969. doi: 10.1038/s41467-020-19803-9. PubMed PMID:33235221 PubMed Central PMC7686350
  9. Yan, S, Khambu, B, Chen, X, Dong, Z, Guo, G, Yin, XM. Hepatic Autophagy Deficiency Remodels Gut Microbiota for Adaptive Protection via FGF15-FGFR4 Signaling. Cell Mol Gastroenterol Hepatol. 2021;11 (4):973-997. doi: 10.1016/j.jcmgh.2020.10.011. PubMed PMID:33127558 PubMed Central PMC7898036
  10. Stofan, M, Guo, GL. Bile Acids and FXR: Novel Targets for Liver Diseases. Front Med (Lausanne). 2020;7 :544. doi: 10.3389/fmed.2020.00544. PubMed PMID:33015098 PubMed Central PMC7516013
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Categories: Faculty, Toxicology, Member, Tox Member
Updated 9 months ago.

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