Mechanisms of nitric oxide signaling in a wide variety of pathophysiological conditions; molecular mechanisms involved in controlling nitric oxide signaling and the role of nitric oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes; Nitric oxide in inflammatory cells such as macrophages and microglia.

Our laboratory investigates mechanisms of Nitric Oxide signaling in a wide variety of pathophysiological conditions. We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism. In particular, we investigate the role of Nitric Oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes. We are particularly interested in the function of Nitric Oxide in inflammatory cells such as macrophages and microglia. It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted.