Education

• BSc,  (Hons)  University of Edinburgh, Edinburgh, Scotland, UK
• MEd,  Temple University, Philadelphia, PA
• PhD, Temple University, Philadelphia, PA
• Post-Doc, University of Pennsylvania, Philadelphia, PA

Research Areas

Mechanisms of nitric oxide signaling in a wide variety of pathophysiological conditions; molecular mechanisms involved in controlling nitric oxide signaling and the role of nitric oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes; Nitric oxide in inflammatory cells such as macrophages and microglia.

Research

Our laboratory investigates mechanisms of Nitric Oxide signaling in a wide variety of pathophysiological conditions.  We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism.  In particular, we investigate the role of Nitric Oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes.  We are particularly interested in the function of Nitric Oxide in inflammatory cells such as macrophages and microglia.  It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted.

Research Highlights

• S-nitrosylation of pulmonary collectins
• Role of nitric oxide in lung disease
• Mechanisms regulating nitric oxide biosynthesis

Scholarly Activities

• 2001, Florence R.C. Murray Fellowship
• 2000, Translational Medicine Award, Duke University
• 1998, Chartered Chemist, Royal Society of Chemistry
• 1997, Young Investigator Award, International Nitric Oxide Society
• 1996, Young Investigator Award, Oxygen Society
• 1995-97, National Research Service Award, National Institutes of Health-NHLBI in Lung Cell and Molecular Biology
• 1993-95, Russell Conwell Research Fellowship

Recent Publications

1. Malin, SK, Heiston, EM, Battillo, DJ, Ragland, TJ, Gow, AJ, Shapses, SA, Shah, AM, Patrie, JT, Barrett, EJ. Metformin Blunts Vascular Insulin Sensitivity After Exercise Training in Adults at Risk for Metabolic Syndrome. J Clin Endocrinol Metab. 2025; :. doi: 10.1210/clinem/dgaf551. PubMed PMID:41160096
2. Cary, CM, Moore, TL, Gow, AJ, Stapleton, PA. Micro and nanoplastic inhalation during pregnancy elicits uterine endothelial dysfunction in Sprague Dawley rats by impeding nitric oxide signaling. bioRxiv. 2025; :. doi: 10.1101/2025.09.12.675811. PubMed PMID:41000905 PubMed Central PMC12458175
3. Seymore, T, Guo, C, Bellomo, A, Herbert, J, Laskin, D, Gow, A, Stapleton, P. Inhalation of titanium dioxide nanoparticles during gestation alters placental bioenergetics in a sex-related manner in rats. Placenta. 2025;168 :168-176. doi: 10.1016/j.placenta.2025.06.018. PubMed PMID:40592188 PubMed Central PMC12291600
4. Meshanni, JA, Stevenson, ER, Zhang, D, Sun, R, Ona, NA, Reagan, EK, Abramova, E, Guo, CJ, Wilkinson, M, Baboo, I et al.. Targeted delivery of TGF-β mRNA to murine lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers. Nat Commun. 2025;16 (1):1806. doi: 10.1038/s41467-025-56448-y. PubMed PMID:39984450 PubMed Central PMC11845678
5. Pappas, G, Gow, A, Punjabi, NM, Aurora, RN. Sex-specific differences in overnight nitrate levels in persons with obstructive sleep apnea and type 2 diabetes. Sleep Med. 2025;128 :159-164. doi: 10.1016/j.sleep.2025.02.011. PubMed PMID:39952069
6. Lee, JM, Meshanni, JA, Vayas, KN, Sunil, VR, Radbel, J, Laskin, JD, Laskin, DL, Gow, AJ. Inhaled ozone induces distinct alterations in pulmonary function in models of acute and episodic exposure in female mice. Toxicol Sci. 2025;204 (1):70-78. doi: 10.1093/toxsci/kfae162. PubMed PMID:39798125 PubMed Central PMC11879009
7. Lu, FT, Gupta, D, Fiedler, N, Satish, U, Black, KG, Legard, A, De Resende, A, Guo, C, Gow, AJ, Kipen, HM et al.. Mechanisms Underlying Acute Cognitive Impairment following Carbon Dioxide Inhalation in a Randomized Crossover Trial. Environ Health Perspect. 2024;132 (10):107702. doi: 10.1289/EHP14806. PubMed PMID:39466336 PubMed Central PMC11515854
8. Aggarwal, T, Bellomo, A, Stevenson, ER, Herbert, J, Laskin, DL, Gow, AJ, Izgu, EC. Protocol for detecting nitrative stress in biological lipid membranes in murine cells and tissues. STAR Protoc. 2024;5 (3):103268. doi: 10.1016/j.xpro.2024.103268. PubMed PMID:39215997 PubMed Central PMC11403049
9. Atochina-Vasserman, E, Meshanni, J, Stevenson, E, Zhang, D, Sun, R, Ona, N, Reagan, E, Abramova, E, Guo, CJ, Wilkinson, M et al.. Targeted delivery of TGF-β mRNA to lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers. Res Sq. 2024; :. doi: 10.21203/rs.3.rs-4656663/v1. PubMed PMID:39041040 PubMed Central PMC11261981
10. Smith, LC, Abramova, E, Vayas, K, Rodriguez, J, Gelfand-Titiyevksiy, B, Roepke, TA, Laskin, JD, Gow, AJ, Laskin, DL. Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation. Toxicol Sci. 2024;201 (1):103-117. doi: 10.1093/toxsci/kfae081. PubMed PMID:38897669 PubMed Central PMC11347782