EOHSI

Biographical Info

Research Areas

My laboratory is interested in numerous facets of central nervous system pathology, particularly in developmental neurotoxicology, traumatic brain injury, and the differential responses of various CNS cell types to insult.  We are particularly interested in the recruitment of endogenous neural stem cells to sites of injury as a potential therapeutic approach to brain injury.

The laboratory also provides diagnostic histopathology support to investigators across the Rutgers community

Research Highlights

• Established a lateral fluid percussion model for TBI and initiated studies of persistent blood-brain-barrier defects following closed-head injury
• Investigated the comparative neurotoxicity of amphoterocin-type fungicides
• Examining the developmental pathology of low-dose methylmercury exposure in vitro and in vivo
• Documented recruitment of periventricular stem cells to the hippocampus following chemical injury

Scholarly Activities

• Review Article Editor-NeuroToxicology
• President-MidAtlantic Society of Toxicology
• External Advisory Committee-University of Michigan Toxicology Program

Recent Publications

1. Eddy, K, Gupta, K, Pelletier, JC, Isola, AL, Marinaro, C, Rasheed, MA, Campagnolo, J, Eddin, MN, Rossi, M, Fateeva, A et al.. A Spontaneous Melanoma Mouse Model Applicable for a Longitudinal Chemotherapy and Immunotherapy Study. J Invest Dermatol. 2023;143 (10):2007-2018.e6. doi: 10.1016/j.jid.2023.03.1664. PubMed PMID:36997110 PubMed Central PMC10524215
2. Chen, T, Liu, AB, Sun, S, Ajami, NJ, Ross, MC, Wang, H, Zhang, L, Reuhl, K, Kobayashi, K, Onishi, JC et al.. Green Tea Polyphenols Modify the Gut Microbiome in db/db Mice as Co-Abundance Groups Correlating with the Blood Glucose Lowering Effect. Mol Nutr Food Res. 2019;63 (8):e1801064. doi: 10.1002/mnfr.201801064. PubMed PMID:30667580 PubMed Central PMC6494111
3. Feng, S, Dai, Z, Liu, AB, Huang, J, Narsipur, N, Guo, G, Kong, B, Reuhl, K, Lu, W, Luo, Z et al.. Intake of stigmasterol and β-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863 (10):1274-1284. doi: 10.1016/j.bbalip.2018.08.004. PubMed PMID:30305244 PubMed Central PMC6226309
4. Hossain, MM, Weig, B, Reuhl, K, Gearing, M, Wu, LJ, Richardson, JR. The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Na_v 1.6. Exp Neurol. 2018;308 :111-119. doi: 10.1016/j.expneurol.2018.07.005. PubMed PMID:30017881 PubMed Central PMC7404626
5. Jabbar, S, Reuhl, K, Sarkar, DK. Prenatal alcohol exposure increases the susceptibility to develop aggressive prolactinomas in the pituitary gland. Sci Rep. 2018;8 (1):7720. doi: 10.1038/s41598-018-25785-y. PubMed PMID:29769550 PubMed Central PMC5955957
6. Huang, J, Feng, S, Liu, A, Dai, Z, Wang, H, Reuhl, K, Lu, W, Yang, CS. Green Tea Polyphenol EGCG Alleviates Metabolic Abnormality and Fatty Liver by Decreasing Bile Acid and Lipid Absorption in Mice. Mol Nutr Food Res. 2018;62 (4):. doi: 10.1002/mnfr.201700696. PubMed PMID:29278293 PubMed Central PMC6350933
7. Meng, Y, Wiseman, JA, Nemtsova, Y, Moore, DF, Guevarra, J, Reuhl, K, Banks, WA, Daneman, R, Sleat, DE, Lobel, P et al.. A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism. Mol Ther. 2017;25 (7):1531-1543. doi: 10.1016/j.ymthe.2017.03.037. PubMed PMID:28456380 PubMed Central PMC5498811
8. Garbuzenko, OB, Ivanova, V, Kholodovych, V, Reimer, DC, Reuhl, KR, Yurkow, E, Adler, D, Minko, T. Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s). Nanomedicine. 2017;13 (6):1983-1992. doi: 10.1016/j.nano.2017.04.005. PubMed PMID:28434932 PubMed Central PMC5546883
9. Chen, JX, Wang, H, Liu, A, Zhang, L, Reuhl, K, Yang, CS. From the Cover: PhIP/DSS-Induced Colon Carcinogenesis in CYP1A-Humanized Mice and the Possible Role of Lgr5+ Stem Cells. Toxicol Sci. 2017;155 (1):224-233. doi: 10.1093/toxsci/kfw190. PubMed PMID:27664423 PubMed Central PMC5216652
10. Das, G, Yu, Q, Hui, R, Reuhl, K, Gale, NW, Zhou, R. EphA5 and EphA6: regulation of neuronal and spine morphology. Cell Biosci. 2016;6 :48. doi: 10.1186/s13578-016-0115-5. PubMed PMID:27489614 PubMed Central PMC4971699