Lauren Aleksunes’Lab 

Recent Publications

1. Rivera-Núñez, Z, Kinkade, CW, Juenke, A, Hansel, M, Heltberg, D, Sharada, A, Anthony, S, Brinker, A, Fields, J, Rosen, T et al.. Diet and mycoestrogen exposure in a pregnancy cohort: the Jersey Babies pilot study. J Expo Sci Environ Epidemiol. 2026; :. doi: 10.1038/s41370-026-00940-0. PubMed PMID:42362911
2. Asby, S, Wen, X, Goedken, M, Ames, B, Shams, S, Thompson, LE, Lanis, J, Kostka-Newman, Z, Larsen, K, Tilden, S et al.. Nephrotoxicity of Immune Checkpoint Inhibitors in Mice with a Human Immune System. bioRxiv. 2026; :. doi: 10.64898/2026.05.07.723340. PubMed PMID:42182101 PubMed Central PMC13192905
3. Campbell, MJ, Patel, M, Jiang, C, Wen, X, Xiao, S, Aleksunes, LM. Transporter-Mediated Uptake of Microcystin-LR in Human Trophoblasts: Regulation By Oxygen Concentration and Cell Fusion. bioRxiv. 2026; :. doi: 10.64898/2026.03.22.713491. PubMed PMID:41929031 PubMed Central PMC13041809
4. Jia, X, Wang, T, Russo, DP, Aleksunes, LM, Xiao, S, Zhu, H. vToxiNet: a biologically constrained deep learning framework for interpretable prediction of drug-induced hepatotoxicity. bioRxiv. 2026; :. doi: 10.64898/2026.02.26.708259. PubMed PMID:41846970 PubMed Central PMC12991077
5. Chung, E, Russo, DP, Aleksunes, LM, Warner, GR, Zhu, H. Hierarchical Mechanistic Modeling of Complex Toxicity Endpoints from Public Concentration-Response Data. Environ Sci Technol. 2026;60 (3):2539-2555. doi: 10.1021/acs.est.5c09326. PubMed PMID:41528243 PubMed Central PMC12854766
6. Basaly, V, Henry, ZR, Taylor, RE, Kong, B, Yang, I, Brinker, A, Yang, Z, Zhou, P, Joseph, LB, Aleksunes, L et al.. Mutation of PXR phosphorylation motif at Ser347 disrupts lipid and bile acid homeostasis in diet-induced metabolic dysfunction-associated steatohepatitis in mice. Drug Metab Dispos. 2026;54 (2):100222. doi: 10.1016/j.dmd.2025.100222. PubMed PMID:41520575 PubMed Central PMC12975368
7. Daood, NJ, Carey, SR, Chung, E, Wang, T, Kreutz, A, Girireddy, M, Chakravarti, S, Kleinstreuer, NC, Tiley, JB, Aleksunes, LM et al.. Machine Learning Modeling for ABC Transporter Efflux and Inhibition: Data Curation, Model Development, and New Compound Interaction Predictions. Mol Pharm. 2025;22 (11):7022-7035. doi: 10.1021/acs.molpharmaceut.5c01065. PubMed PMID:41115055 PubMed Central PMC12587445
8. Nguyen, DQ, Hyman, S, Medley, E, Bozack, AK, Kahn, LG, Kannan, K, Guitierrez, A, Aleksunes, LM, Rivera-Núñez, Z, Cowell, W et al.. Maternal organophosphate pesticide exposure in relation to birthweight: Modification by placenta transporter genotype. Placenta. 2025;172 :40-43. doi: 10.1016/j.placenta.2025.10.011. PubMed PMID:41109040 PubMed Central PMC12822829
9. Thompson, LE, Tuey, SM, Gonzalez, PG, Chesterman, CS, McGinnis, CD, Lucia, MS, Aleksunes, LM, Edelstein, CL, Joy, MS. Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin. AAPS Open. 2025;11 :. doi: 10.1186/s41120-025-00107-5. PubMed PMID:40881130 PubMed Central PMC12387945
10. Yasrebi, A, Rojas, CM, Anthony, S, Feltri, S, Evelyn, J, Wiersielis, K, Adams, S, Basaly, V, Guo, GL, Aleksunes, LM et al.. Dual Effects of Maternal Diet and Perinatal Organophosphate Flame Retardant Treatment on Offspring Development, Behavior and Metabolism. Toxics. 2025;13 (8):. doi: 10.3390/toxics13080639. PubMed PMID:40863915 PubMed Central PMC12390071