Lauren Aleksunes’Lab 

Recent Publications

1. Henry, ZR, Armstrong, L, Maliha, S, Jia, X, Gao, S, Taylor, RE, Basaly, V, Otersen, K, Yang, Z, Rizzolo, D et al.. Deletion of hepatic FXR leads to more severe MASH development in female mice. Hepatol Commun. 2025;9 (6):. doi: 10.1097/HC9.0000000000000693. PubMed PMID:40377496 PubMed Central PMC12088634
2. Wang, T, Jia, X, Aleksunes, LM, Shen, H, Deng, HW, Zhu, H. Developmental toxicity: artificial intelligence-powered assessments. Trends Pharmacol Sci. 2025; :. doi: 10.1016/j.tips.2025.04.005. PubMed PMID:40374415
3. Rivera-Núñez, Z, Kinkade, C, Brinker, A, Zhang, R, Buckley, B, Brunner, J, Ohman-Strickland, P, Qiu, X, Qasem, RJ, Fallon, JK et al.. Mycoestrogen Exposure during Pregnancy: Impact of the ABCG2 Q141K Variant on Birth and Placental Outcomes. Environ Health Perspect. 2025;133 (5):57001. doi: 10.1289/EHP14478. PubMed PMID:40126888 PubMed Central PMC12052082
4. Asby, SC, Thompson, LE, Goedken, M, Lucia, SM, Dominguez, AT, Kar, A, Pitts, TM, Kiseljak-Vassiliades, K, Lang, J, Aleksunes, LM et al.. Pathological findings of immunotherapy-induced nephrotoxicity in a humanized immune system mouse model. Kidney Int. 2025;107 (5):930-934. doi: 10.1016/j.kint.2025.01.021. PubMed PMID:39922378
5. Thompson, LE, Ghimire, A, Wen, X, Kim, C, Choza, J, Doherty, CL, Buckley, BT, Bowles, DW, O’Bryant, CL, Pfister, DG et al.. A Pharmacokinetic/Toxicodynamic Model of Cisplatin Nephrotoxicity Using the Kidney Injury Molecule-1 Biomarker. J Pharmacol Clin Toxicol. 2024;12 (1):. doi: 10.47739/pharmacology1184. PubMed PMID:39726772 PubMed Central PMC11671133
6. Thompson, LE, Ghimire, A, Wen, X, Kim, C, Doherty, CL, Buckley, BT, Bowles, DW, O’Bryant, CL, Jaimes, EA, Aleksunes, LM et al.. Population Pharmacokinetic Model of Platinum Disposition in Cancer Patients Receiving Cisplatin and Randomized to 5-HT₃ Antagonist Antiemetic Drugs. J Clin Pharmacol. 2024; :. doi: 10.1002/jcph.6177. PubMed PMID:39711135
7. Toth, E, Li, H, Frost, K, Sample, P, Jilek, J, Greenfield, S, You, D, Kozlosky, D, Goedken, M, Paine, MF et al.. Nonalcoholic steatohepatitis increases plasma retention of sorafenib-glucuronide in a mouse model by altering hepatocyte hopping. Acta Pharm Sin B. 2024;14 (11):4874-4882. doi: 10.1016/j.apsb.2024.09.004. PubMed PMID:39664440 PubMed Central PMC11628858
8. Kinkade, CW, Rivera-Núñez, Z, Brinker, A, Buckley, B, Waysack, O, Kautz, A, Meng, Y, Ohman Strickland, P, Block, R, Groth, SW et al.. Urinary mycoestrogens and gestational weight gain in the UPSIDE pregnancy cohort. Environ Health. 2024;23 (1):103. doi: 10.1186/s12940-024-01141-8. PubMed PMID:39567992 PubMed Central PMC11580541
9. Kinkade, CW, Brinker, A, Buckley, B, Waysack, O, Fernandez, ID, Kautz, A, Meng, Y, Shi, H, Brunner, J, Ohman-Strickland, P et al.. Sociodemographic and dietary predictors of maternal and placental mycoestrogen concentrations in a US pregnancy cohort. J Expo Sci Environ Epidemiol. 2025;35 (3):382-392. doi: 10.1038/s41370-024-00722-6. PubMed PMID:39363096 PubMed Central PMC11968447
10. Taylor, R, Basaly, V, Kong, B, Yang, I, Brinker, AM, Capece, G, Bhattacharya, A, Henry, ZR, Otersen, K, Yang, Z et al.. Effects of therapeutically approved individual bile acids on the development of metabolic dysfunction-associated steatohepatitis a low bile acid mouse model. Toxicol Sci. 2024;202 (2):179-195. doi: 10.1093/toxsci/kfae110. PubMed PMID:39302723