Lauren Aleksunes’Lab 

Recent Publications

1. Chung, E, Russo, DP, Aleksunes, LM, Warner, GR, Zhu, H. Hierarchical Mechanistic Modeling of Complex Toxicity Endpoints from Public Concentration-Response Data. Environ Sci Technol. 2026; :. doi: 10.1021/acs.est.5c09326. PubMed PMID:41528243
2. Basaly, V, Henry, ZR, Taylor, RE, Kong, B, Yang, I, Brinker, A, Yang, Z, Zhou, P, Joseph, LB, Aleksunes, L et al.. Mutation of PXR phosphorylation motif at Ser347 disrupts lipid and bile acid homeostasis in diet-induced metabolic dysfunction-associated steatohepatitis in mice. Drug Metab Dispos. 2025;54 (2):100222. doi: 10.1016/j.dmd.2025.100222. PubMed PMID:41520575
3. Daood, NJ, Carey, SR, Chung, E, Wang, T, Kreutz, A, Girireddy, M, Chakravarti, S, Kleinstreuer, NC, Tiley, JB, Aleksunes, LM et al.. Machine Learning Modeling for ABC Transporter Efflux and Inhibition: Data Curation, Model Development, and New Compound Interaction Predictions. Mol Pharm. 2025;22 (11):7022-7035. doi: 10.1021/acs.molpharmaceut.5c01065. PubMed PMID:41115055 PubMed Central PMC12587445
4. Nguyen, DQ, Hyman, S, Medley, E, Bozack, AK, Kahn, LG, Kannan, K, Guitierrez, A, Aleksunes, LM, Rivera-Núñez, Z, Cowell, W et al.. Maternal organophosphate pesticide exposure in relation to birthweight: Modification by placenta transporter genotype. Placenta. 2025;172 :40-43. doi: 10.1016/j.placenta.2025.10.011. PubMed PMID:41109040
5. Thompson, LE, Tuey, SM, Gonzalez, PG, Chesterman, CS, McGinnis, CD, Lucia, MS, Aleksunes, LM, Edelstein, CL, Joy, MS. Bardoxolone methyl improves survival and reduces clinical measures of kidney injury in tumor-bearing mice treated with cisplatin. AAPS Open. 2025;11 :. doi: 10.1186/s41120-025-00107-5. PubMed PMID:40881130 PubMed Central PMC12387945
6. Yasrebi, A, Rojas, CM, Anthony, S, Feltri, S, Evelyn, J, Wiersielis, K, Adams, S, Basaly, V, Guo, GL, Aleksunes, LM et al.. Dual Effects of Maternal Diet and Perinatal Organophosphate Flame Retardant Treatment on Offspring Development, Behavior and Metabolism. Toxics. 2025;13 (8):. doi: 10.3390/toxics13080639. PubMed PMID:40863915 PubMed Central PMC12390071
7. Veiga-Lopez, A, Elkin, ER, Harris, SM, Blake, BE, Paquette, AG, Aleksunes, LM, Stapleton, PA. Current approaches and advances in placental toxicology. Trends Endocrinol Metab. 2026;37 (1):31-54. doi: 10.1016/j.tem.2025.05.001. PubMed PMID:40473500 PubMed Central PMC12353762
8. Henry, ZR, Armstrong, L, Maliha, S, Jia, X, Gao, S, Taylor, RE, Basaly, V, Otersen, K, Yang, Z, Rizzolo, D et al.. Deletion of hepatic FXR leads to more severe MASH development in female mice. Hepatol Commun. 2025;9 (6):. doi: 10.1097/HC9.0000000000000693. PubMed PMID:40377496 PubMed Central PMC12088634
9. Wang, T, Jia, X, Aleksunes, LM, Shen, H, Deng, HW, Zhu, H. Developmental toxicity: artificial intelligence-powered assessments. Trends Pharmacol Sci. 2025;46 (6):486-502. doi: 10.1016/j.tips.2025.04.005. PubMed PMID:40374415 PubMed Central PMC12145233
10. Rivera-Núñez, Z, Kinkade, C, Brinker, A, Zhang, R, Buckley, B, Brunner, J, Ohman-Strickland, P, Qiu, X, Qasem, RJ, Fallon, JK et al.. Mycoestrogen Exposure during Pregnancy: Impact of the ABCG2 Q141K Variant on Birth and Placental Outcomes. Environ Health Perspect. 2025;133 (5):57001. doi: 10.1289/EHP14478. PubMed PMID:40126888 PubMed Central PMC12052082