Lauren Aleksunes Pharm.D., Ph.D., D.A.B.T.
Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology
Work EOHSI Room 426 (Labs: Rooms 439, 434, 430, and 429) 170 Frelinghuysen Rd Piscataway New Jersey 08854 work
Work Phone: 848-445-5518 (office)work
Work Phone: 848-445-0187 (lab)work
Work Email: email@example.comINTERNET
Dr. Aleksunes is Professor in the Rutgers University, Ernest Mario School of Pharmacy, Department of Pharmacology and Toxicology, Project Lead of the NJ Alliance for Clinical and Translational Science CTSA Workforce Development Core, and Director of the Joint Graduate Program in Toxicology and the Summer Undergraduate Research Fellowship. Dr. Aleksunes is also a member of the CounterAct Research Center of Excellence where she Co-Leads the Research Education Core and Pharmacology and Drug Development Core. Within the NIEHS P30 Center for Environmental Exposures and Disease, Dr. Aleksunes is Co-Director of the Environmental/Chemical Pathology Core and Co-Director of Career Development and Mentoring.
Drugs and chemicals are often too large to enter and exit cells unassisted. Transporter proteins can be used as gates that regulate which chemicals leave cells. In fact, the ATP-binding cassette transporters (ABC) are members of a superfamily of transporters found in the plasma membrane. ABC transporters function as efflux pumps that remove chemicals from the cell. Our laboratory studies members of three families of efflux transporters: ABCB1 (Multidrug resistance protein 1, MDR1, P-glycoprotein), ABCC1-6 (Multidrug resistance-associated proteins, MRP), and ABCG2 (Breast cancer resistance protein, BCRP). These transporters are important in removing chemicals from the liver and kidneys and can protect against target organ toxicity. Similarly, these efflux pumps are expressed in the placenta and participate in maternal-fetal xenobiotic disposition, thereby protecting the developing fetus from toxicant exposure.
Dr. Aleksunes’ laboratory investigates how drug transporters in the liver, kidneys, brain, and placenta protect against the accumulation and toxicity of pharmaceuticals and environmental chemicals. Her studies aim to 1) characterize substrates and inhibitors for efflux transporters, 2) determine how genetic variants influence transporter function, and 3) understand the regulatory mechanisms that control expression of transporters. Dr. Aleksunes’ laboratory utilizes molecular biology, cell biology, in vivo transgenic animal, explant human tissue, biomarkers of toxicity, and pharmacokinetic approaches to study the interplay of drug transport and toxicology.
Dr. Aleksunes and her laboratory are funded by NIH R01ES021800, R01ES029275, R01GM123330, and F31ES029794 Dr. Aleksunes is Principal Investigator for T32ES007148 and R25ES020721 and Intern Programs from the Society of Toxicology and the American Society for Pharmacology and Experimental Therapeutics. She also participates in U54TR002258 and U54AR055073.
The Aleksunes laboratory includes research scientists (Xia Wen), graduate students (Ludwik Gorczyca, Danielle Kozlosky, and Maxine Abustan), postdoctoral fellows (Ranran Zhang and Lauren Walker), and undergraduate students (Fatimah Mosaad, Brian Rinelli, Chris Pella, Duaa Eisa, Hye Min Shin, Perihan Badawy, Rebecca Sun, and Victoria Woo). Students from China Pharmaceutical University and Sun Yat-Sen University spend rotations in the Aleksunes laboratory as well.
Highlights from the research team include:
- Identification of pharmacogenetic risk factors, drug interactions, and biomarkers for cisplatin-induced nephrotoxicity in humans.
- Investigation of enterohepatic bile acid signaling and homeostasis during pregnancy.
- Characterization of environmental chemicals as substrates and inhibitors of human placental efflux transporters.
- Elucidation of regulatory mechanisms controlling transporter expression in the placenta.
- Characterization of cell-cell communication between microglia and brain endothelial cells.
- Identification of transporters in the blood-brain barrier that regulate exposure to pesticides.
- Screening of diverse chemical sets to inform the development and refinement of virtual Adverse Outcome Pathways (vAOPs).
In the News
- Wen, X, Kozlosky, D, Zhang, R, Doherty, C, Buckley, B, Barrett, E, Aleksunes, LM. BCRP/ABCG2 Transporter Regulates Accumulation of Cadmium in Kidney Cells:Role of the Q141K Variant in Modulating Nephrotoxicity. Drug Metab Dispos. 2021; :. doi: 10.1124/dmd.121.000446. PubMed PMID:34074729
- Kinkade, CW, Rivera-Núñez, Z, Gorcyzca, L, Aleksunes, LM, Barrett, ES. Impact of Fusarium-Derived Mycoestrogens on Female Reproduction: A Systematic Review. Toxins (Basel). 2021;13 (6):. doi: 10.3390/toxins13060373. PubMed PMID:34073731
- Gorczyca, L, Du, J, Bircsak, KM, Wen, X, Vetrano, AM, Aleksunes, LM. Low oxygen tension differentially regulates the expression of placental solute carriers and ABC transporters. FEBS Lett. 2021;595 (6):811-827. doi: 10.1002/1873-3468.13937. PubMed PMID:32978975 PubMed Central PMC7987846
- Palomares, KT, Parobchak, N, Ithier, MC, Aleksunes, LM, Castaño, PM, So, M, Faro, R, Heller, D, Wang, B, Rosen, T et al.. Fetal Exosomal Platelet-activating Factor Triggers Functional Progesterone Withdrawal in Human Placenta. Reprod Sci. 2021;28 (1):252-262. doi: 10.1007/s43032-020-00283-7. PubMed PMID:32780361
- Ciallella, HL, Russo, DP, Aleksunes, LM, Grimm, FA, Zhu, H. Predictive modeling of estrogen receptor agonism, antagonism, and binding activities using machine- and deep-learning approaches. Lab Invest. 2021;101 (4):490-502. doi: 10.1038/s41374-020-00477-2. PubMed PMID:32778734 PubMed Central PMC7873171
- Zhao, L, Ciallella, HL, Aleksunes, LM, Zhu, H. Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling. Drug Discov Today. 2020;25 (9):1624-1638. doi: 10.1016/j.drudis.2020.07.005. PubMed PMID:32663517 PubMed Central PMC7572559
- George, B, Wen, X, Mercke, N, Gomez, M, O’Bryant, C, Bowles, DW, Hu, Y, Hogan, SL, Joy, MS, Aleksunes, LM et al.. Time-dependent changes in kidney injury biomarkers in patients receiving multiple cycles of cisplatin chemotherapy. Toxicol Rep. 2020;7 :571-576. doi: 10.1016/j.toxrep.2020.04.003. PubMed PMID:32382514 PubMed Central PMC7200609
- You, D, Richardson, JR, Aleksunes, LM. Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition. Drug Metab Dispos. 2020;48 (6):459-480. doi: 10.1124/dmd.119.089953. PubMed PMID:32193359 PubMed Central PMC7250367
- Gorczyca, L, Aleksunes, LM. Transcription factor-mediated regulation of the BCRP/ABCG2 efflux transporter: a review across tissues and species. Expert Opin Drug Metab Toxicol. 2020;16 (3):239-253. doi: 10.1080/17425255.2020.1732348. PubMed PMID:32077332 PubMed Central PMC7167287
- Zhao, L, Russo, DP, Wang, W, Aleksunes, LM, Zhu, H. Mechanism-Driven Read-Across of Chemical Hepatotoxicants Based on Chemical Structures and Biological Data. Toxicol Sci. 2020;174 (2):178-188. doi: 10.1093/toxsci/kfaa005. PubMed PMID:32073637 PubMed Central PMC7098374
Categories: Faculty, Toxicology, Member, Tox Member
Updated 2 months ago.