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Guofeng You Ph.D.

Distinguished Professor Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Work William Levine Hall Room 218 160 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-6349
Photo of Guofeng You Ph.D.

Biographical Info

Research Areas

Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters

Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.

Research Highlights

Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.

Scholarly Activities

  • 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
  • 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
  • 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
  • 2012 NIH Review Panel for COBRE Pilot Project Applications
  • 2012 NIH Special Emphasis Review Panel for Program Project Grants.
  • 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
  • 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
  • 2011 NIH Special Emphasis Review Panel for Program Project Grants.
  • 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
  • 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
  • 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
  • 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
  • 2006-present Editorial Board, Pharmaceutical Research

Recent Publications

  1. Liu, J, Han, Y, Hua, W, Wang, Y, You, G, Li, P, Liao, F, Zhao, L, Ding, Y. Improved flowing behaviour and gas exchange of stored red blood cells by a compound porous structure. Artif Cells Nanomed Biotechnol. 2019;47 (1):1888-1897. doi: 10.1080/21691401.2019.1614018. PubMed PMID:31072140
  2. Wang, H, You, G. The SUMO-Specific Protease Senp2 Regulates SUMOylation, Expression and Function of Human Organic Anion Transporter 3. Biochim Biophys Acta Biomembr. 2019;1861 (7):1293-1301. doi: 10.1016/j.bbamem.2019.04.007. PubMed PMID:31054272
  3. Li, SY, You, GJ, Du, LJ, Li, WW, Liu, YY, Du, JT, Xia, J, Huang, Y. Complete Genome Sequence of a Class I Newcastle Disease Virus Strain Isolate from a Breeding Chicken Flock in Sichuan, China. Microbiol Resour Announc. 2019;8 (18):. doi: 10.1128/MRA.00337-19. PubMed PMID:31048383 PubMed Central PMC6498238
  4. Lv, M, You, G, Wang, J, Fu, Q, Gupta, A, Li, J, Sun, J. Identification of a novel ANO5 missense mutation in a Chinese family with familial florid osseous dysplasia. J. Hum. Genet. 2019; :. doi: 10.1038/s10038-019-0601-9. PubMed PMID:30996299
  5. Zhang, J, Xu, K, You, G, Wang, B, Zhao, L. Causation Analysis of Risk Coupling of Gas Explosion Accident in Chinese Underground Coal Mines. Risk Anal. 2019; :. doi: 10.1111/risa.13311. PubMed PMID:30970163
  6. Gao, T, Jiang, M, Liu, X, You, G, Wang, W, Sun, Z, Ma, A, Chen, J. Patterned Polyvinyl Alcohol Hydrogel Dressings with Stem Cells Seeded for Wound Healing. Polymers (Basel). 2019;11 (1):. doi: 10.3390/polym11010171. PubMed PMID:30960155 PubMed Central PMC6401986
  7. Liu, C, Zhang, J, You, G. Interaction of Anticancer Drugs with Human Organic Anion Transporter hOAT4. J Oncol. 2019;2019 :1951786. doi: 10.1155/2019/1951786. PubMed PMID:30941173 PubMed Central PMC6421026
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Categories: Faculty, Toxicology
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