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Guofeng You Ph.D.

Distinguished Professor Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Work William Levine Hall Room 218 160 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-6349
Photo of Guofeng You Ph.D.

Biographical Info

Research Areas

Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters

Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.

Research Highlights

Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.

Scholarly Activities

  • 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
  • 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
  • 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
  • 2012 NIH Review Panel for COBRE Pilot Project Applications
  • 2012 NIH Special Emphasis Review Panel for Program Project Grants.
  • 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
  • 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
  • 2011 NIH Special Emphasis Review Panel for Program Project Grants.
  • 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
  • 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
  • 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
  • 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
  • 2006-present Editorial Board, Pharmaceutical Research

Recent Publications

  1. You, G, Hou, J, Xu, Y, Miao, L, Ao, Y, Xing, B. Surface Properties and Environmental Transformations Controlling the Bioaccumulation and Toxicity of Cerium Oxide Nanoparticles: A Critical Review. Rev Environ Contam Toxicol. 2020; :. doi: 10.1007/398_2020_42. PubMed PMID:32462332
  2. Mao, Y, Zhang, Z, Zeng, W, Zhang, W, Zhang, J, You, G, Wei, Y. A clinical study of efficacy of polyglycolic acid patch in surgery for pneumothorax:a systematic review and meta-analysis. J Cardiothorac Surg. 2020;15 (1):117. doi: 10.1186/s13019-020-01137-8. PubMed PMID:32460862
  3. Chu, Z, Wang, Y, You, G, Wang, Q, Ma, N, Li, B, Zhao, L, Zhou, H. The P50 value detected by the oxygenation-dissociation analyser and blood gas analyser. Artif Cells Nanomed Biotechnol. 2020;48 (1):867-874. doi: 10.1080/21691401.2020.1770272. PubMed PMID:32460558
  4. Kuo, CT, You, GT, Jian, YJ, Chen, TS, Siao, YC, Hsu, AL, Ching, TT. AMPK-mediated formation of stress granules is required for dietary restriction-induced longevity in Caenorhabditis elegans. Aging Cell. 2020; :e13157. doi: 10.1111/acel.13157. PubMed PMID:32432401
  5. You, G, Lv, Y, Jiang, Y, Yi, C. A Novel Fault Diagnosis Scheme for Rolling Bearing Based on Convex Optimization in Synchroextracting Chirplet Transform. Sensors (Basel). 2020;20 (10):. doi: 10.3390/s20102813. PubMed PMID:32429156
  6. You, G, Li, C, Mao, Y, Ren, X, Liu, Y, Wang, M. A comparative analysis of raw and processed Radix Paeoniae Alba using high performance liquid chromatography, chemometrics and antioxidant activity. Biomed. Chromatogr. 2020; :e4901. doi: 10.1002/bmc.4901. PubMed PMID:32428269
  7. Li, S, Li, Y, Feng, B, Liang, J, You, G, Liu, X, Xian, L. Bi(iii)-catalyzed aminooxygenation of propargyl amidines to synthesize 2-fluoroalkyl imidazole-5-carbaldehydes and their decarbonylations. Chem. Commun. (Camb.). 2020; :. doi: 10.1039/d0cc02143a. PubMed PMID:32390034
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Categories: Faculty, Toxicology
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