Guofeng You Ph.D.Distinguished Professor Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters
Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.
Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.
- 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
- 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
- 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
- 2012 NIH Review Panel for COBRE Pilot Project Applications
- 2012 NIH Special Emphasis Review Panel for Program Project Grants.
- 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
- 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
- 2011 NIH Special Emphasis Review Panel for Program Project Grants.
- 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
- 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
- 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
- 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
- 2006-present Editorial Board, Pharmaceutical Research
- You, G. Preface: Molecular Mechanisms, Novel Modes of Regulation, and Therapeutic Strategies. Adv. Drug Deliv. Rev. 2017;116 :1-2. doi: 10.1016/j.addr.2017.08.008. PubMed PMID:28882217
- Wang, H, You, G. SGK1/Nedd4-2 signaling pathway regulates the activity of human organic anion transporters 3. Biopharm Drug Dispos. 2017;38 (8):449-457. doi: 10.1002/bdd.2085. PubMed PMID:28608480 PubMed Central PMC5668173
- Xu, D, Zhang, J, Zhang, Q, Fan, Y, Liu, C, You, G. PKC/Nedd4-2 Signaling Pathway Regulates the Cell Surface Expression of Drug Transporter hOAT1. Drug Metab. Dispos. 2017;45 (8):887-895. doi: 10.1124/dmd.117.075861. PubMed PMID:28572241 PubMed Central PMC5506456
- Xu, D, You, G. Rethinking the regulation of l-carnitine transport in skeletal muscle cells. Focus on "Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes". Am. J. Physiol., Cell Physiol. 2017;312 (6):C687-C688. doi: 10.1152/ajpcell.00093.2017. PubMed PMID:28424167 PubMed Central PMC5494588
- Xu, D, Huang, H, Toh, MF, You, G. Serum- and glucocorticoid-inducible kinase sgk2 stimulates the transport activity of human organic anion transporters 1 by enhancing the stability of the transporter. Int J Biochem Mol Biol. 2016;7 (1):19-26. . PubMed PMID:27335683 PubMed Central PMC4913228
- Toh, MF, Suh, W, Wang, H, Zhou, P, Hu, L, You, G. Inhibitory effects of chemotherapeutics on human organic anion transporter hOAT4. Int J Biochem Mol Biol. 2016;7 (1):11-8. . PubMed PMID:27335682 PubMed Central PMC4913227
- Xu, D, Wang, H, You, G. Posttranslational Regulation of Organic Anion Transporters by Ubiquitination: Known and Novel. Med Res Rev. 2016;36 (5):964-79. doi: 10.1002/med.21397. PubMed PMID:27291023 PubMed Central PMC5147025