EOHSI

Research Areas

Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters

Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.

Research Highlights

Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.

Scholarly Activities

• 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
• 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
• 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
• 2012 NIH Review Panel for COBRE Pilot Project Applications
• 2012 NIH Special Emphasis Review Panel for Program Project Grants.
• 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
• 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
• 2011 NIH Special Emphasis Review Panel for Program Project Grants.
• 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
• 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
• 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
• 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
• 2006-present Editorial Board, Pharmaceutical Research

Recent Publications

1. Chen, J, Kang, Y, Lin, S, He, S, He, Y, Xu, X, Xu, H, You, G, Xu, D. Single-port plus one in pediatric robotic-assisted Lich-Gregoir ureteral reimplantation for vesicoureteral reflux, a comparative analysis with short-term outcomes. BMC Urol. 2024;24 (1):81. doi: 10.1186/s12894-024-01467-y. PubMed PMID:38589861 PubMed Central PMC11000388
2. You, G, Jin, Z, Lu, S, Ren, J, Zhang, Y, Hu, K, Xie, S. Emission factors and source profiles of volatile organic compounds from the automobile manufacturing industry. Sci Total Environ. 2024;927 :172183. doi: 10.1016/j.scitotenv.2024.172183. PubMed PMID:38575016
3. You, G. Preface to Special Issue: Drug Transporters: Regulation and Roles in Therapeutic Strategies. Pharmaceutics. 2024;16 (3):. doi: 10.3390/pharmaceutics16030425. PubMed PMID:38543319 PubMed Central PMC10976069
4. Zhang, H, You, G, Yang, Q, Jin, G, Lv, G, Fan, L, Chen, Y, Li, H, Yi, S, Li, H et al.. CX3CR1 deficiency promotes resolution of hepatic ischemia-reperfusion injury by regulating homeostatic function of liver infiltrating macrophages. Biochim Biophys Acta Mol Basis Dis. 2024;1870 (5):167130. doi: 10.1016/j.bbadis.2024.167130. PubMed PMID:38537684
5. Wang, R, Yang, Y, You, G, Huang, L, Zhou, X, Jiang, S, Shi, H, Wang, G, Zhang, L. Chronic lateral ankle instability using anterior tibiofibular ligament distal fascicle transfer augmentation repair: an anatomical, biomechanical, and histological study. Front Bioeng Biotechnol. 2024;12 :1326036. doi: 10.3389/fbioe.2024.1326036. PubMed PMID:38515619 PubMed Central PMC10955350
6. Niu, G, You, G, Liu, X. Interactions of hsian-tsao polysaccharide with corn starch to reduce its in vitro digestibility. Int J Biol Macromol. 2024;265 (Pt 1):130951. doi: 10.1016/j.ijbiomac.2024.130951. PubMed PMID:38503373
7. Xu, L, Zhang, J, Dong, J, Chen, Q, Ma, S, Jiang, J, Zheng, Y, Zhuo, W, Tang, X, Gao, Y et al.. A bibliometric analysis of Kawasaki disease from 1974 to 2022. Heliyon. 2024;10 (5):e27290. doi: 10.1016/j.heliyon.2024.e27290. PubMed PMID:38486756 PubMed Central PMC10937693