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Guofeng You Ph.D.

Distinguished Professor Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Work William Levine Hall Room 218 160 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-6349
Photo of Guofeng You Ph.D.

Biographical Info

Research Areas

Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters

Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.

Research Highlights

Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.

Scholarly Activities

  • 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
  • 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
  • 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
  • 2012 NIH Review Panel for COBRE Pilot Project Applications
  • 2012 NIH Special Emphasis Review Panel for Program Project Grants.
  • 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
  • 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
  • 2011 NIH Special Emphasis Review Panel for Program Project Grants.
  • 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
  • 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
  • 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
  • 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
  • 2006-present Editorial Board, Pharmaceutical Research

Recent Publications

  1. Ge, T, Wu, HC, Zhou, YY, Shen, SM, Zhu, LG, You, GX. MiR-296-3p may affect the proliferation and migration of non-small cell lung cancer cells via regulating RABL3. Eur Rev Med Pharmacol Sci. 2019;23 (13):5823-5830. doi: 10.26355/eurrev_201907_18321. PubMed PMID:31298353
  2. Cao, X, You, G, Li, H, Li, D, Wang, M, Ren, X. Comparative Investigation for Rotten Xylem (kuqin) and Strip Types (tiaoqin) of Scutellaria baicalensis Georgi Based on Fingerprinting and Chemical Pattern Recognition. Molecules. 2019;24 (13):. doi: 10.3390/molecules24132431. PubMed PMID:31269661
  3. Liang, S, Fan, X, Zhao, M, Shan, X, Li, W, Ding, P, You, G, Hong, Z, Yang, X, Luan, G et al.. Clinical practice guidelines for the diagnosis and treatment of adult diffuse glioma-related epilepsy. Cancer Med. 2019; :. doi: 10.1002/cam4.2362. PubMed PMID:31240876
  4. Shang, P, Chen, G, Zu, G, Song, X, Jiao, P, You, G, Zhao, J, Li, H, Zhou, H. Long noncoding RNA expression analysis reveals the regulatory effects of nitinol-based nanotubular coatings on human coronary artery endothelial cells. Int J Nanomedicine. 2019;14 :3297-3309. doi: 10.2147/IJN.S204067. PubMed PMID:31190794 PubMed Central PMC6519025
  5. Sun, R, Chen, M, Hu, Y, Lan, Y, Gan, L, You, G, Yue, M, Wang, H, Xia, B, Zhao, J et al.. CYP3A4/5 mediates the metabolic detoxification of humantenmine, a highly toxic alkaloid from Gelsemium elegans Benth. J Appl Toxicol. 2019; :. doi: 10.1002/jat.3813. PubMed PMID:31119768
  6. Hou, J, Li, T, Miao, L, You, G, Xu, Y, Liu, S. Effects of titanium dioxide nanoparticles on algal and bacterial communities in periphytic biofilms. Environ. Pollut. 2019;251 :407-414. doi: 10.1016/j.envpol.2019.04.136. PubMed PMID:31103000
  7. Zhang, X, Ye, J, Shen, N, Tao, Y, Han, L, Qiu, W, Zhang, H, Liang, L, Fan, Y, Wang, J et al.. In vitro residual activities in 20 variants of phenylalanine hydroxylase and genotype-phenotype correlation in phenylketonuria patients. Gene. 2019;707 :239-245. doi: 10.1016/j.gene.2019.05.029. PubMed PMID:31102715
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Categories: Faculty, Toxicology
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