EOHSI

Biographical Info

Research Areas

Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters

Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.

Research Highlights

Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.

Scholarly Activities

• 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
• 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
• 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
• 2012 NIH Review Panel for COBRE Pilot Project Applications
• 2012 NIH Special Emphasis Review Panel for Program Project Grants.
• 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
• 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
• 2011 NIH Special Emphasis Review Panel for Program Project Grants.
• 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
• 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
• 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
• 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
• 2006-present Editorial Board, Pharmaceutical Research

Recent Publications

1. Hong, W, You, G, Luo, Z, Zhang, M, Chen, J. High gestational leucine level dampens WDPCP/MAPK signaling to impair the EMT and migration of cardiac microvascular endothelial cells in congenital heart defects. Pulm Circ. 2024;14 (4):e70013. doi: 10.1002/pul2.70013. PubMed PMID:39582775 PubMed Central PMC11582015
2. Zhang, M, Lin, N, You, G, Wang, Y, Wang, L, Zou, C, Yan, R, Zhang, Y. Variations and influencing factors of vegetation net primary productivity over 31 years in Wuyishan National Park, China. Sci Rep. 2024;14 (1):29002. doi: 10.1038/s41598-024-71812-6. PubMed PMID:39578471 PubMed Central PMC11584899
3. Ying, X, Shi, Z, Shao, R, You, G, Song, Z. Correction: Efficacy and safety analysis of anlotinib in combination with immune checkpoint inhibitors for second-line and subsequent extensive-stage small-cell lung cancer. Neoplasma. 2024;71 (5):509. doi: 10.4149/neo_2024_231104N572COR. PubMed PMID:39556434
4. Miao, L, Li, W, Li, C, Adyel, TM, You, G, Xu, Y, Wu, J, Yao, Y, Kong, M, Feng, J et al.. Effects of reduced flow gradient on benthic biofilm communities' ecological network and community assembly. Environ Res. 2024;264 (Pt 1):120362. doi: 10.1016/j.envres.2024.120362. PubMed PMID:39547568
5. Li, T, Li, Q, Fan, X, Wang, L, You, G. Seizure Burden and Clinical Risk Factors in Glioma-Related Epilepsy: Insights From MRI Voxel-Based Lesion-Symptom Mapping. J Magn Reson Imaging. 2024; :. doi: 10.1002/jmri.29663. PubMed PMID:39545320
6. Miao, L, Zhang, J, Luo, D, Adyel, TM, Ao, Y, Li, C, Yao, Y, Wu, J, You, G, Hou, J et al.. Distinct effects of flow intermittency on the benthic microbial diversity and their denitrification on different substrates. Sci Total Environ. 2024;957 :177394. doi: 10.1016/j.scitotenv.2024.177394. PubMed PMID:39528219
7. Huang, HH, Chang, JT, You, GR, Fu, YF, Shen, EY, Huang, YF, Shen, CR, Cheng, AJ. MiRNA Profiling of Areca Nut-Induced Carcinogenesis in Head and Neck Cancer. Cancers (Basel). 2024;16 (21):. doi: 10.3390/cancers16213710. PubMed PMID:39518147 PubMed Central PMC11545612