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Chung “CS” Yang, Ph.D.
Distinguished Professor & John L. Colaizzi Endowed Chair in Pharmacy
Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Research Areas
Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.
Research Highlights
- Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
- Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
- Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
- Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
- Conducting translational research on tocopherols in prostate cancer patients.
Scholarly Activities
- Conduct research as described above.
- Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
- Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
- Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.
Recent Publications
- Liu, C, Chen, J, Che, Y, He, L, Luo, S, Yang, CS, Chen, T. Interactive Effects of Arabinoxylan Oligosaccharides and Green Tea Polyphenols on Obesity Management and Gut Microbiota Modulation in High-Fat Diet-Fed Mice. J Agric Food Chem. 2024; :. doi: 10.1021/acs.jafc.4c02022. PubMed PMID:38984620
- Hou, MH, Chen, CJ, Yang, CS, Wang, YC, Chen, Y. Structural and functional characterization of cyclic pyrimidine-regulated anti-phage system. Nat Commun. 2024;15 (1):5634. doi: 10.1038/s41467-024-49861-2. PubMed PMID:38965224 PubMed Central PMC11224242
- Yang, CS, Geng, JH, Wu, PY, Huang, JC, Hu, HM, Chen, SC, Kuo, CH. Sex difference in the associations among hyperuricemia with self-reported peptic ulcer disease in a large Taiwanese population study. Front Med (Lausanne). 2024;11 :1383290. doi: 10.3389/fmed.2024.1383290. PubMed PMID:38919943 PubMed Central PMC11197382
- Hong, D, Kim, HK, Yang, W, Yoon, C, Kim, M, Yang, CS, Yoon, S. Integrative analysis of single-cell RNA-seq and gut microbiome metabarcoding data elucidates macrophage dysfunction in mice with DSS-induced ulcerative colitis. Commun Biol. 2024;7 (1):731. doi: 10.1038/s42003-024-06409-w. PubMed PMID:38879692 PubMed Central PMC11180211
- Husain, K, Coppola, D, Yang, CS, Malafa, MP. Effect of vitamin E δ-tocotrienol and aspirin on Wnt signaling in human colon cancer stem cells and in adenoma development in APCmin/+ mice. Carcinogenesis. 2024; :. doi: 10.1093/carcin/bgae041. PubMed PMID:38877828
- Gibbs, KW, Semler, MW, Driver, BE, Seitz, KP, Stempek, SB, Taylor, C, Resnick-Ault, D, White, HD, Gandotra, S, Doerschug, KC et al.. Noninvasive Ventilation for Preoxygenation during Emergency Intubation. N Engl J Med. 2024;390 (23):2165-2177. doi: 10.1056/NEJMoa2313680. PubMed PMID:38869091
- Ivanesthi, IR, Latifah, E, Amrullah, LF, Tseng, YK, Chuang, TH, Pan, HC, Yang, CS, Liu, SY, Wang, CC. Adaptation of a eukaryote-like ProRS to a prokaryote-like tRNAPro. Nucleic Acids Res. 2024;52 (12):7158-7170. doi: 10.1093/nar/gkae483. PubMed PMID:38842939 PubMed Central PMC11229370
Hilly (ILL) Yang, M.S., Ph.D.
Associate Director of Methods Research
Chemixal Analytical Facility CoreRutgers University – Chemistry & Chemical Biology
Kate York,, LCSW
Cllinician Supervisor
World Trade Center Health ProgramEOHSI – Clinical Research and Occupational Medicine
Guofeng You, Ph.D.
Distinguished Professor
Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Research Areas
Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters
Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.
Research Highlights
Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.
Scholarly Activities
- 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
- 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
- 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
- 2012 NIH Review Panel for COBRE Pilot Project Applications
- 2012 NIH Special Emphasis Review Panel for Program Project Grants.
- 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
- 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
- 2011 NIH Special Emphasis Review Panel for Program Project Grants.
- 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
- 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
- 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
- 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
- 2006-present Editorial Board, Pharmaceutical Research
Recent Publications
- Yu, H, Gao, D, You, G, Li, W, Wang, Y, Chen, Y, Zhao, L. An ex vivo method to evaluate vasoactivity induced by hemoglobin-based oxygen carriers in resistance vessels. Front Bioeng Biotechnol. 2024;12 :1376806. doi: 10.3389/fbioe.2024.1376806. PubMed PMID:39007056 PubMed Central PMC11239391
- Ni, Y, You, G, Gong, Y, Su, X, Du, Y, Wang, X, Ding, X, Fu, Q, Zhang, M, Cheng, T et al.. Human yolk sac-derived innate lymphoid-biased multipotent progenitors emerge prior to hematopoietic stem cell formation. Dev Cell. 2024; :. doi: 10.1016/j.devcel.2024.06.010. PubMed PMID:38996461
- Ying, X, Shi, Z, Shao, R, You, G, Song, Z. Efficacy and safety analysis of anlotinib in combination with immune checkpoint inhibitors for second-line and subsequent extensive-stage small-cell lung cancer. Neoplasma. 2024;71 (3):297-305. doi: 10.4149/neo_2024_231104N572. PubMed PMID:38958712
- Zhu, Z, Hu, Y, Ye, F, Teng, H, You, G, Zeng, Y, Tian, M, Xu, J, Li, J, Liu, Z et al.. IKIP downregulates THBS1/FAK signaling to suppress migration and invasion by glioblastoma cells. Oncol Res. 2024;32 (7):1173-1184. doi: 10.32604/or.2024.042456. PubMed PMID:38948026 PubMed Central PMC11211642
- Chen, X, Shen, R, Zhu, D, Luo, S, You, G, Li, R, Hong, X, Li, R, Wu, J, Huang, Y et al.. Drug repurposing opportunities for chronic kidney disease. iScience. 2024;27 (6):109953. doi: 10.1016/j.isci.2024.109953. PubMed PMID:38947510 PubMed Central PMC11214293
- Zhang, J, Qian, C, You, G, Wang, T, Saifullah, Y, Abdi-Ghaleh, R, Chen, H. Harnessing the Missing Spectral Correlation for Metasurface Inverse Design. Adv Sci (Weinh). 2024; :e2308807. doi: 10.1002/advs.202308807. PubMed PMID:38946621
- Ni, Y, Li, L, Bao, Y, You, G, Li, J. Relationship between perceived organisational support, self-efficacy, proactive personality and career self-management among nurses: a moderated mediation analysis. BMJ Open. 2024;14 (6):e081334. doi: 10.1136/bmjopen-2023-081334. PubMed PMID:38904141 PubMed Central PMC11191799
Lily Young, Ph.D.
Professor and Dean of International Programs
Rutgers University, School of Environmental and Biological SciencesEOHSI – Environmental and Population Health Bio-Sciences
Dr. Young is a Professor and Chair in Rutgers Department of Environmental Sciences and Biotechnology Center for Agriculture and the Environment. She is a member of the Scientific Advisory Board of the U.S. Department of Defense Strategic Environmental Research and Development Program. She also serves on the EC-US Task Force on Environmental Biotechnology.
Research Areas
Examining the instrinsic ability of anaerobic communities from NY-NJ Harbor sediments todegrade alkanes and PAHs, and environmental factors which affect the activity Determining the novel microbial chemistry of the anaerobic pathways of naphthalene, methylnapthalene and phenanthrene by active consortia, and that of the alkanes by newly isolated pure cultures; Investigating methods to improve or enhance natural rates of biodegradation; Developing biochemical markers for assessing intrinsic biodegradation; Isolating novel anaerobes able to degrade additional petroleum constituents and other aromatic compounds; Characterizing the anaerobic toluene pathway in a denitrifying strain with a molecular genetic approach.
Scholarly Activities
- 2001 Research Excellence Award, Board of Trustees, Rutgers Univeristy
- 1999 Research Excellence Award, Cook College, NJ Agricultural Experiment Station, Rutgers University
- 1996 Invited presentation to the Presidents’ Circle of the National Academy of Sciences (Advisory group to NAS President Bruce Albert, comprised of 100 buisness leaders) – Colloquium on “Water Resources for the 21st Century”; presentation title, “Environmental Biotechnology”
Recent Publications
- Vigh-Larsen, JF, Junge, N, Cialdella-Kam, L, Tomás, R, Young, L, Krustrup, P, Mohr, M, Nybo, L. Testing in Intermittent Sports-Importance for Training and Performance Optimization in Adult Athletes. Med Sci Sports Exerc. 2024;56 (8):1505-1537. doi: 10.1249/MSS.0000000000003442. PubMed PMID:39004796
- Young, LS. Out of Many. J Trauma Nurs. ;31 (4):179-180. doi: 10.1097/JTN.0000000000000794. PubMed PMID:38990871
- Mcgee, LMC, Carpinteyro Sanchez, AG, Perieteanu, M, Eskandari, K, Bian, Y, Mackie, L, Young, L, Beveridge, R, Suckling, CJ, Roberts, CW et al.. Strathclyde minor groove binders (S-MGBs) with activity against Acanthamoeba castellanii. J Antimicrob Chemother. 2024; :. doi: 10.1093/jac/dkae221. PubMed PMID:38980760
- Huang, Y, Chen, L, Li, L, Qi, Y, Tong, H, Wu, H, Xu, J, Leng, L, Cheema, S, Sun, G et al.. Downregulation of adipose LPL by PAR2 contributes to the development of hypertriglyceridemia. JCI Insight. 2024;9 (13):. doi: 10.1172/jci.insight.173240. PubMed PMID:38973609
- Rempakos, A, Alexandrou, M, Mutlu, D, Kalyanasundaram, A, Ybarra, LF, Bagur, R, Choi, JW, Poommipanit, P, Khatri, JJ, Young, L et al.. Predicting Successful Chronic Total Occlusion Crossing With Primary Antegrade Wiring Using Machine Learning. JACC Cardiovasc Interv. 2024; :. doi: 10.1016/j.jcin.2024.04.043. PubMed PMID:38970585
- Wang, J, Wang, M, Moshiri, A, Harris, RA, Raveendran, M, Nguyen, T, Kim, S, Young, L, Wang, K, Wiseman, R et al.. Genetic diversity of 1,845 rhesus macaques improves genetic variation interpretation and identifies disease models. Nat Commun. 2024;15 (1):5658. doi: 10.1038/s41467-024-49922-6. PubMed PMID:38969634 PubMed Central PMC11226599
- Coppeto, DJ, Martin, JS, Ringen, EJ, Palmieri, V, Young, LJ, Jaeggi, AV. Peptides and primate personality: Central and peripheral oxytocin and vasopressin levels and social behavior in two baboon species (Papio hamadryas and Papio anubis). Peptides. 2024;179 :171270. doi: 10.1016/j.peptides.2024.171270. PubMed PMID:38969236
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