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Chung “CS” Yang, Ph.D.
Distinguished Professor & John L. Colaizzi Endowed Chair in Pharmacy
Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Research Areas
Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.
Research Highlights
- Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
- Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
- Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
- Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
- Conducting translational research on tocopherols in prostate cancer patients.
Scholarly Activities
- Conduct research as described above.
- Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
- Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
- Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.
Recent Publications
- Ko, HJ, Chen, SM, Yang, CS. [The Effects of a Digital Multimedia Foot Ulcer Care Program on Health Beliefs and Self-Care Behaviors in People With Diabetic Foot Ulcer]. Hu Li Za Zhi. 2024;71 (6):59-71. doi: 10.6224/JN.202412_71(6).08. PubMed PMID:39618136
- Warinhomhoun, S, Raiputta, J, Rangsee, PN, Yang, CS, Chueamchaitrakun, P. Effect of Ultrasound-Assisted Extraction and Drying Methods on Bioactive Compounds, Phenolic Composition, and Antioxidant Activity of Assam Tea Cultivar (Camellia sinensis var. assamica) Cultivated in Thailand. Adv Pharmacol Pharm Sci. 2024;2024 :5772961. doi: 10.1155/2024/5772961. PubMed PMID:39512303 PubMed Central PMC11540878
- Chen, CC, Yen, TH, Li, JR, Chen, CJ, Yang, CS, Lai, JY, Lin, SJ, Yeh, CH, Hsu, SW, Lin, MY et al.. Artificial intelligence algorithms enhance urine cytology reporting confidence in postoperative follow-up for upper urinary tract urothelial carcinoma. Int Urol Nephrol. 2024; :. doi: 10.1007/s11255-024-04270-8. PubMed PMID:39509034
- Chang, KY, Yang, CS, Lai, JY, Lin, SJ, Li, JR, Liu, TJ, Yang, WL, Lin, MY, Yeh, CH, Hsu, SW et al.. An Artificial Intelligence-assisted Diagnostic System Improves Upper Urine Tract Cytology Diagnosis. In Vivo. 2024;38 (6):3016-3021. doi: 10.21873/invivo.13785. PubMed PMID:39477382 PubMed Central PMC11535956
- Yoon, C, Kim, HK, Ham, YS, Gil, WJ, Mun, SJ, Cho, E, Yuk, JM, Yang, CS. Toxoplasma gondii macrophage migration inhibitory factor shows anti-Mycobacterium tuberculosis potential via AZIN1/STAT1 interaction. Sci Adv. 2024;10 (43):eadq0101. doi: 10.1126/sciadv.adq0101. PubMed PMID:39453997 PubMed Central PMC11506136
- Cheng, HE, Yeh, HZ, Yang, CS, Yang, SS, Liao, SC. Disseminated Cryptococcus over pancreas, lung, and brain: a case report. J Med Case Rep. 2024;18 (1):513. doi: 10.1186/s13256-024-04836-1. PubMed PMID:39438983 PubMed Central PMC11515725
- Lu, X, He, Y, Guo, JQ, Wang, Y, Yan, Q, Xiong, Q, Shi, H, Hou, Q, Yin, J, An, YB et al.. Dynamics of epitranscriptomes uncover translational reprogramming directed by ac4C in rice during pathogen infection. Nat Plants. 2024;10 (10):1548-1561. doi: 10.1038/s41477-024-01800-1. PubMed PMID:39317771
Hilly (ILL) Yang, M.S., Ph.D.
Associate Director of Methods Research
Chemixal Analytical Facility CoreRutgers University – Chemistry & Chemical Biology
Kate York,, LCSW
Cllinician Supervisor
World Trade Center Health ProgramEOHSI – Clinical Research and Occupational Medicine
Guofeng You, Ph.D.
Distinguished Professor
Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Research Areas
Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters
Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.
Research Highlights
Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.
Scholarly Activities
- 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
- 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
- 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
- 2012 NIH Review Panel for COBRE Pilot Project Applications
- 2012 NIH Special Emphasis Review Panel for Program Project Grants.
- 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
- 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
- 2011 NIH Special Emphasis Review Panel for Program Project Grants.
- 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
- 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
- 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
- 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
- 2006-present Editorial Board, Pharmaceutical Research
Recent Publications
- Miao, L, Jin, Z, Ci, H, Adyel, TM, Deng, X, You, G, Xu, Y, Wu, J, Yao, Y, Kong, M et al.. Dynamic changes of leachates of aged plastic debris under different suspended sand concentrations and their toxicity. J Hazard Mater. 2024;485 :136874. doi: 10.1016/j.jhazmat.2024.136874. PubMed PMID:39700944
- Wang, X, You, G, Liu, C, Sun, Y. Bioaugmentation strategies in co-composting anaerobically digested food waste with agricultural by-products: Enhancing fertilizer quality and microbial communities. Ecotoxicol Environ Saf. 2024;290 :117539. doi: 10.1016/j.ecoenv.2024.117539. PubMed PMID:39700777
- Huang, C, Ye, ZM, Qin, YS, You, GP, Wei, Z, Cai, H. Radical α-C-H Alkylation and Heteroarylation of Benzyl Anilines Enabled by Organic Photoredox Catalysis. Org Lett. 2024; :. doi: 10.1021/acs.orglett.4c04278. PubMed PMID:39688377
- You, G, Long, H, Shen, X, Yin, H, Zhang, S. Emerging roles of circular RNAs on the regulation of production traits in chicken. Poult Sci. 2024;104 (1):104612. doi: 10.1016/j.psj.2024.104612. PubMed PMID:39647355
- You, G, Yang, J, Wang, X, Liu, Q, Ding, R. Development of an atmospheric boundary layer detection system based on a rotary-wing unmanned aerial vehicle. Rev Sci Instrum. 2024;95 (12):. doi: 10.1063/5.0227462. PubMed PMID:39625356
- Yu, Z, You, G. Recent Advances on the Regulations of Organic Anion Transporters. Pharmaceutics. 2024;16 (11):. doi: 10.3390/pharmaceutics16111355. PubMed PMID:39598479 PubMed Central PMC11597148
- Hong, W, You, G, Luo, Z, Zhang, M, Chen, J. High gestational leucine level dampens WDPCP/MAPK signaling to impair the EMT and migration of cardiac microvascular endothelial cells in congenital heart defects. Pulm Circ. 2024;14 (4):e70013. doi: 10.1002/pul2.70013. PubMed PMID:39582775 PubMed Central PMC11582015
Lily Young, Ph.D.
Professor and Dean of International Programs
Rutgers University, School of Environmental and Biological SciencesEOHSI – Environmental and Population Health Bio-Sciences
Dr. Young is a Professor and Chair in Rutgers Department of Environmental Sciences and Biotechnology Center for Agriculture and the Environment. She is a member of the Scientific Advisory Board of the U.S. Department of Defense Strategic Environmental Research and Development Program. She also serves on the EC-US Task Force on Environmental Biotechnology.
Research Areas
Examining the instrinsic ability of anaerobic communities from NY-NJ Harbor sediments todegrade alkanes and PAHs, and environmental factors which affect the activity Determining the novel microbial chemistry of the anaerobic pathways of naphthalene, methylnapthalene and phenanthrene by active consortia, and that of the alkanes by newly isolated pure cultures; Investigating methods to improve or enhance natural rates of biodegradation; Developing biochemical markers for assessing intrinsic biodegradation; Isolating novel anaerobes able to degrade additional petroleum constituents and other aromatic compounds; Characterizing the anaerobic toluene pathway in a denitrifying strain with a molecular genetic approach.
Scholarly Activities
- 2001 Research Excellence Award, Board of Trustees, Rutgers Univeristy
- 1999 Research Excellence Award, Cook College, NJ Agricultural Experiment Station, Rutgers University
- 1996 Invited presentation to the Presidents’ Circle of the National Academy of Sciences (Advisory group to NAS President Bruce Albert, comprised of 100 buisness leaders) – Colloquium on “Water Resources for the 21st Century”; presentation title, “Environmental Biotechnology”
Recent Publications
- Wang, JY, Michki, SN, Sitaraman, S, Banaschewski, BJ, Jamal, R, Gokey, JJ, Lin, SM, Katzen, JB, Basil, MC, Cantu, E et al.. Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome. JCI Insight. 2024; :. doi: 10.1172/jci.insight.183483. PubMed PMID:39699958
- Miller, MA, Calle, PP, Gai, J, Sanchez, C, Young, L. SEROCONVERSION CAN PRECEDE CULTURE CONFIRMED DIAGNOSIS OF MYCOBACTERIUM TUBERCULOSIS INFECTION IN ASIAN ELEPHANTS (ELEPHAS MAXIMUS) BY DECADES. J Zoo Wildl Med. 2024;55 (4):1082-1087. doi: 10.1638/2024-0034. PubMed PMID:39699155
- Garza, MY, Williams, TB, Ounpraseuth, S, Hu, Z, Lee, J, Snowden, J, Walden, AC, Simon, AE, Devlin, LA, Young, LW et al.. Comparing Medical Record Abstraction (MRA) error rates in an observational study to pooled rates identified in the data quality literature. BMC Med Res Methodol. 2024;24 (1):304. doi: 10.1186/s12874-024-02424-x. PubMed PMID:39695394 PubMed Central PMC11653794
- Goedeke, L, Ma, Y, Gaspar, RC, Nasiri, A, Lee, J, Zhang, D, Galsgaard, KD, Hu, X, Zhang, J, Guerrera, N et al.. SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts. J Clin Invest. 2024;134 (24):. doi: 10.1172/JCI176708. PubMed PMID:39680452 PubMed Central PMC11645152
- Law, KF, Syropoulos, S, O’Connor, BB, Young, L. The Probabilistic Price of Life Across Time: Generational and Probabilistic Distance Render a Life Today Worth More Than Ten Tomorrow. Pers Soc Psychol Bull. 2024; :1461672241303993. doi: 10.1177/01461672241303993. PubMed PMID:39676757
- Dowling, GP, Daly, GR, Hegarty, A, Flanagan, M, Ola, M, Fallon, R, Cocchiglia, S, Singh, V, Sheehan, KM, Bane, F et al.. Neoadjuvant HER2 inhibition induces ESR1 DNA methylation alterations resulting in clinically relevant ER expression changes in breast cancers. Cancer Commun (Lond). 2024; :. doi: 10.1002/cac2.12640. PubMed PMID:39676516
- Strepkos, D, Rempakos, A, Alexandrou, M, Mutlu, D, Carvalho, PEP, Bahbah, A, Kontantinis, S, Choi, JW, Gorgulu, S, Jaffer, FA et al.. Association of Proximal Vessel Tortuosity with Technical Success and Clinical Outcomes: Analysis From the Progress-CTO Registry. Catheter Cardiovasc Interv. 2024; :. doi: 10.1002/ccd.31338. PubMed PMID:39660868
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