Biographical Info

Research Areas

Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters

Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.

Research Highlights

Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.

Scholarly Activities

• 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
• 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
• 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
• 2012 NIH Review Panel for COBRE Pilot Project Applications
• 2012 NIH Special Emphasis Review Panel for Program Project Grants.
• 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
• 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
• 2011 NIH Special Emphasis Review Panel for Program Project Grants.
• 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
• 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
• 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
• 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
• 2006-present Editorial Board, Pharmaceutical Research

Recent Publications

1. Liang, F, Wang, B, Geng, J, You, G, Fa, J, Zhang, M, Sun, H, Chen, H, Fu, Q, Zhang, X et al.. SORBS2 is a genetic factor contributing to cardiac malformation of 4q deletion syndrome patients. Elife. 2021;10 :. doi: 10.7554/eLife.67481. PubMed PMID:34099102 PubMed Central PMC8186900
2. Shen, Y, Xue, C, You, G, Liu, C. miR-9 alleviated the inflammatory response and apoptosis in caerulein-induced acute pancreatitis by regulating FGF10 and the NF-κB signaling pathway. Exp Ther Med. 2021;22 (2):795. doi: 10.3892/etm.2021.10227. PubMed PMID:34093751 PubMed Central PMC8170642
3. Chen, YJ, Chang, JT, You, GR, Huang, CY, Fan, KH, Cheng, AJ. Panel biomarkers associated with cancer invasion and prognostic prediction for head-neck cancer. Biomark Med. 2021; :. doi: 10.2217/bmm-2021-0213. PubMed PMID:34032473
4. Song, J, Jung, H, You, G, Mok, H. Cancer-Cell-Derived Hybrid Vesicles from MCF-7 and HeLa Cells for Dual-Homotypic Targeting of Anticancer Drugs. Macromol Biosci. 2021; :e2100067. doi: 10.1002/mabi.202100067. PubMed PMID:33963822
5. Li, J, Kaneda, MM, Ma, J, Li, M, Shepard, RM, Patel, K, Koga, T, Sarver, A, Furnari, F, Xu, B et al.. PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. Proc Natl Acad Sci U S A. 2021;118 (16):. doi: 10.1073/pnas.2009290118. PubMed PMID:33846242 PubMed Central PMC8072253
6. Zhang, H, Yao, W, Zhang, M, Lu, Y, Tang, J, Jiang, M, Mou, X, You, G, Liang, X. Corrigendum to "TTK inhibitor promotes radiosensitivity of liver cancer cells through p21" [Biochem. Biophys. Res. Commun. 550(2021) 84-91]. Biochem Biophys Res Commun. 2021;555 :214. doi: 10.1016/j.bbrc.2021.03.164. PubMed PMID:33840464
7. Shi, T, Song, J, You, G, Yang, Y, Liu, Q, Li, N. The Function of Selenium in Central Nervous System: Lessons from MsrB1 Knockout Mouse Models. Molecules. 2021;26 (5):. doi: 10.3390/molecules26051372. PubMed PMID:33806413 PubMed Central PMC7961861