Biographical Info

Research Areas

Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters

Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.

Research Highlights

Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.

Scholarly Activities

• 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
• 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
• 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
• 2012 NIH Review Panel for COBRE Pilot Project Applications
• 2012 NIH Special Emphasis Review Panel for Program Project Grants.
• 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
• 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
• 2011 NIH Special Emphasis Review Panel for Program Project Grants.
• 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
• 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
• 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
• 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
• 2006-present Editorial Board, Pharmaceutical Research

Recent Publications

1. Zu, B, Zhang, X, You, G, Fu, Q. Generation of a homozygous CRISPR/Cas9-mediated knockout human iPSC line for PTCH1 gene. Stem Cell Res. 2021;56 :102517. doi: 10.1016/j.scr.2021.102517. PubMed PMID:34509918
2. Xu, Y, Yang, S, You, G, Hou, J. Attenuation effects of iron on dissemination of antibiotic resistance genes in anaerobic bioreactor: Evolution of quorum sensing, quorum quenching and dynamics of community composition. J Hazard Mater. 2021;416 :126136. doi: 10.1016/j.jhazmat.2021.126136. PubMed PMID:34492925
3. Lv, L, Peng, M, Wu, L, Dong, Y, You, G, Duan, Y, Yang, W, He, L, Liu, X. Progress in Iron Oxides Based Nanostructures for Applications in Energy Storage. Nanoscale Res Lett. 2021;16 (1):138. doi: 10.1186/s11671-021-03594-z. PubMed PMID:34463837 PubMed Central PMC8408304
4. Cheng, AJ, You, GR, Lee, CJ, Lu, YC, Tang, SJ, Huang, YF, Huang, YC, Lee, LY, Fan, KH, Chen, YC et al.. Systemic Investigation Identifying Salivary miR-196b as a Promising Biomarker for Early Detection of Head-Neck Cancer and Oral Precancer Lesions. Diagnostics (Basel). 2021;11 (8):. doi: 10.3390/diagnostics11081411. PubMed PMID:34441345 PubMed Central PMC8392418
5. Shen, X, Wei, Y, You, G, Liu, W, Amevor, FK, Zhang, Y, He, H, Ma, M, Zhang, Y, Li, D et al.. Circular PPP1R13B RNA Promotes Chicken Skeletal Muscle Satellite Cell Proliferation and Differentiation via Targeting miR-9-5p. Animals (Basel). 2021;11 (8):. doi: 10.3390/ani11082396. PubMed PMID:34438852 PubMed Central PMC8388737
6. You, G, Bickel, B, Daum, MM, Stoll, S. Child-directed speech is optimized for syntax-free semantic inference. Sci Rep. 2021;11 (1):16527. doi: 10.1038/s41598-021-95392-x. PubMed PMID:34400656 PubMed Central PMC8368066
7. Liu, Z, Adyel, TM, Miao, L, You, G, Liu, S, Hou, J. Biofilm influenced metal accumulation onto plastic debris in different freshwaters. Environ Pollut. 2021;285 :117646. doi: 10.1016/j.envpol.2021.117646. PubMed PMID:34380227