Biographical Info

Research Areas

Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.

Research Highlights

• Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
• Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
• Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
• Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
• Conducting translational research on tocopherols in prostate cancer patients.

Scholarly Activities

• Conduct research as described above.
• Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
• Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
• Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.

Recent Publications

1. Chou, YB, Wang, AG, Yang, HY, Chen, KJ, Yang, CS. Refractive status, biometric components, and functional outcomes of patients with threshold retinopathy of prematurity: systemic review and a 17-year longitudinal study. Graefes Arch Clin Exp Ophthalmol. 2022; :. doi: 10.1007/s00417-022-05730-6. PubMed PMID:35729410
2. Yang, CS, Chen, T, Ho, CT. Redox and Other Biological Activities of Tea Catechins That May Affect Health: Mechanisms and Unresolved Issues. J Agric Food Chem. 2022; :. doi: 10.1021/acs.jafc.2c02527. PubMed PMID:35727888
3. Lin, JL, Lin, C, Wang, HL, Wu, SJ, Tang, Y, Yang, CS, Luo, JW, Chi, W, Fang, ZT. Splenic Artery Embolization and Splenectomy for Spontaneous Rupture of Splenic Hemangioma and Its Imaging Features. Front Cardiovasc Med. 2022;9 :925711. doi: 10.3389/fcvm.2022.925711. PubMed PMID:35722106 PubMed Central PMC9205459
4. Ko, LN, Lim, GZ, Chen, XR, Cai, CJ, Liu, KT, Yang, CS. HwMR is a novel magnesium-associated protein. Biophys J. 2022; :. doi: 10.1016/j.bpj.2022.06.010. PubMed PMID:35690905
5. Wu, CH, Ku, CJ, Yu, MW, Yang, JH, Lu, TC, Lin, TR, Yang, CS, Chen, KP. Nonscattering Photodetection in the Propagation of Unidirectional Surface Plasmon Polaritons Embedded with Graphene. ACS Appl Mater Interfaces. 2022; :. doi: 10.1021/acsami.2c03214. PubMed PMID:35675390
6. Zhao, G, Yang, L, Zhong, W, Hu, Y, Tan, Y, Ren, Z, Ban, Q, Yang, CS, Wang, Y, Wang, Z et al.. Polydatin, A Glycoside of Resveratrol, Is Better Than Resveratrol in Alleviating Non-alcoholic Fatty Liver Disease in Mice Fed a High-Fructose Diet. Front Nutr. 2022;9 :857879. doi: 10.3389/fnut.2022.857879. PubMed PMID:35651514 PubMed Central PMC9149290
7. Lee, J, Kim, J, Heo, I, Kim, SJ, Jang, S, Lee, HY, Jang, KS, Yang, CS, Lee, Y, Yoo, WC et al.. One-pot bifunctionalization of silica nanoparticles conjugated with bioorthogonal linkers: application in dual-modal imaging. Biomater Sci. 2022; :. doi: 10.1039/d2bm00258b. PubMed PMID:35611753