Research Areas
The overall focus of our research is immunotoxicology. We are particularly interested in inflammatory mechanisms of tissue injury. Our focus is on macrophages. Although the involvement of macrophages in protecting against invading pathogens and tumor cells is well documented, studies from my laboratory have demonstrated that macrophages also have a “dark side”. Thus, they can be activated to release excessive quantities of proinflammatory and cytotoxic mediators that actually promote tissue injury. An analysis of this process represents the main focus of our research. Two rodent models are being utilized to investigate the role of macrophages and inflammatory mediators in toxicity: the lung and the liver. In each of these tissues, we found that exposure of animals to xenobiotics such as acetaminophen and endotoxin in the liver and ozone, nano/microparticles, mustard vesicants, and chlorine is associated with localized accumulation of macrophages. Moreover, macrophages isolated from the lung or liver of animals treated with tissue specific toxicants are “activated” to release increased quantities of inflammatory mediators such as tumor necrosis factor alpha, nitric oxide and superoxide anion. To analyze the role of these cytotoxic mediators in toxicity, both pharmacologic inhibitors and transgenic mice are being utilized. Another aspect of our studies is to elucidate biochemical and molecular mechanisms mediating macrophage activation in the lung. This has involved investigations on signaling molecules, transcription factors, epigenetic regulators and microvesicles. We have also begun to assess the role of macrophages in tissue repair with a focus on impaired resolution of inflammation as a mechanism underlying tissue injury.
Research Highlights
Recent Awards and Honors
Other Recent Activities
Recent Publications
Distinguished Professor
Department of Environmental & Occupational Health
Environmental and Occupational Health Sciences Institute
Rutgers University School of Public Health, Piscataway, NJ
Director of the Division of Toxicology
Environmental and Occupational Health Sciences Institute (EOHSI)
Rutgers University School of Public Health, Piscataway, NJ
Director
Rutgers University CounterACT Research Center of Excellence
Rutgers University School of Public Health, Piscataway, NJ
Research Areas
Dr. Jeffrey D. Laskin is a Distinguished Professor in the School of Public Health at Rutgers University. He is Director of the Division of Toxicology at the Environmental and Occupational Health Sciences Institute (EOHSI) and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. He is Director of the Rutgers University CounterACT Research Center of Excellence, a major research effort to develop the most promising scientific discoveries that lead to improved medical countermeasures to protect Americans against a chemical attack.
Dr. Laskin received a B.A. in Chemistry and Biology from New York University, NY and a Ph.D. in Experimental Therapeutics from Roswell Park Cancer Institute, SUNY at Buffalo, NY. He was a post-doctoral fellow in the Institute for Cancer Research at the College of Physicians and Surgeons at Columbia University in NY before joining the faculty the Robert Wood Johnson Medical School and the School of Public Health at Rutgers University. Dr. Laskin has served on numerous study sections for the National Institutes of Health and was an invited participant at the National Institutes of Arthritis and Musculoskeletal Disorders Roundtable on Wound Healing. He is a member of the Cancer Institute of New Jersey, the Graduate School of Biomedical Sciences at Rutgers University and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. Dr. Laskin has also served as a member of the corporation of the Marine Biological Laboratory in Woods Hole, Massachusetts.
Dr. Laskin has served as a reviewer on over 30 journals that deal with pharmacology, toxicology and cancer research. With over 250 peer-reviewed publications, three books, and numerous book chapters and editorials, he has been recognized as one of the most cited scientists in the field of chemical toxicology. His research focuses on mechanisms of chemical-induced skin, lung and liver toxicity. He is an expert in mechanisms of chemical toxicity, phototoxicology and redox chemistry. Dr. Laskin has been continuously funded by the NIH for the last 35 years and has served as PI on numerous RO1’s, as a Program Project PI and as a Center Director. Currently, he is completing research on exposure and health effects of chemical warfare agents and is working to identify countermeasures to sulfur mustard exposure.
Research Highlights
Scholarly Activities
Recent Publications
Research Areas
Current research interests are focused on two areas: 1) the interactive effects of exposure to multiple air pollutants and psychosocial stressors, and their cumulative impact on urban disparities in asthma, heart disease and cancer and 2) biological mechanisms underlying the effects of diesel exhaust and other air pollutants on pulmonary and cardiovascular disease. Approaches include community-based participatory research, controlled exposure studies, and semi-controlled “real-world” environmental exposure studies.
Research Highlights
Scholarly Activities
Recent Publications
Research Areas
Our laboratory is multi-disciplinary, with projects that range from organic to biological to analytical. Recent projects include: (i) exploring how damaged DNA differs from normal DNA. Mutated bases are linked to carcinogenesis and cell death and it is therefore important to understand how these damaged bases differ from normal bases. In particular, we are interested in how the damaged bases are identified and excised by enzymes; (ii) identification of small RNAs in cell lysates (collaborative project); (iii) studying the properties of silanols, particularly acidity, to characterize their potential as catalysts (collaborative project); (iv) examining the properties and reactivities of N-heterocyclic carbenes, which are a “hot” topic nowadays due to their versatility (as organometallic ligands, organocatalysts, components in environmentally friendly solvents). Our methods include traditional organic tools (including synthesis) as well as spectroscopy (mass spectrometry, UV absorbance, NMR), and computational chemistry.
Recent Publications
Research Areas
Research Highlights
Scholarly Activities
Recent Publications
Recent Publications
Copyright © 2021, Rutgers, The State University of New Jersey