Jeffrey D Laskin, Ph.D.

Distinguished Professor & Director, Division of Toxicology Environmental and Occupational Health Sciences InstituteEOHSI – Toxicology
Work EOHSI Room 441 170 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-0170 Website: Jeffrey Laskin’s Bio Page
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Biographical Info

Distinguished Professor
Department of Environmental & Occupational Health
Environmental and Occupational Health Sciences Institute
Rutgers University School of Public Health, Piscataway, NJ

Director of the Division of Toxicology
Environmental and Occupational Health Sciences Institute (EOHSI)
Rutgers University School of Public Health, Piscataway, NJ

Rutgers University CounterACT Research Center of Excellence
Rutgers University School of Public Health, Piscataway, NJ


Research Areas

Dr. Jeffrey D. Laskin is a Distinguished Professor in the School of Public Health at Rutgers University.  He is Director of the Division of Toxicology at the Environmental and Occupational Health Sciences Institute (EOHSI) and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. He is Director of the Rutgers University CounterACT Research Center of Excellence, a major research effort to develop the most promising scientific discoveries that lead to improved medical countermeasures to protect Americans against a chemical attack.

Dr. Laskin received a B.A. in Chemistry and Biology from New York University, NY and a Ph.D. in Experimental Therapeutics from Roswell Park Cancer Institute, SUNY at Buffalo, NY. He was a post-doctoral fellow in the Institute for Cancer Research at the College of Physicians and Surgeons at Columbia University in NY before joining the faculty the Robert Wood Johnson Medical School and the School of Public Health at Rutgers University. Dr. Laskin has served on numerous study sections for the National Institutes of Health and was an invited participant at the National Institutes of Arthritis and Musculoskeletal Disorders Roundtable on Wound Healing. He is a member of the Cancer Institute of New Jersey, the Graduate School of Biomedical Sciences at Rutgers University and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. Dr. Laskin has also served as a member of the corporation of the Marine Biological Laboratory in Woods Hole, Massachusetts.

Dr. Laskin has served as a reviewer on over 30 journals that deal with pharmacology, toxicology and cancer research. With over 250 peer-reviewed publications, three books, and numerous book chapters and editorials, he has been recognized as one of the most cited scientists in the field of chemical toxicology. His research focuses on mechanisms of chemical-induced skin, lung and liver toxicity. He is an expert in mechanisms of chemical toxicity, phototoxicology and redox chemistry. Dr. Laskin has been continuously funded by the NIH for the last 35 years and has served as PI on numerous RO1’s, as a Program Project PI and as a Center Director. Currently, he is completing research on exposure and health effects of chemical warfare agents and is working to identify countermeasures to sulfur mustard exposure.

Research Highlights

  • Demonstrated that sulfur mustard induces autophagy in the skin
  • Developed models for sulfur mustard-induced skin and lung toxicity
  • Synthesized >100 inhibitors of chemical-induced skin and lung injury
  • Demonstrated that UVB light is an inducer of prostaglandin and leukotriene biosynthetic enzymes

Scholarly Activities

  • Founder, New Jersey Basic and Applied Dermatology Forum
  • NASA, Issues in Advanced Environmental Health and Advanced Food Technology
  • NIH grant reviewer
  • Member, Cancer Institute of New Jersey
  • Member, NJ Department of Homeland Security Preparedness College
  • Executive Committee, NJ Universities Homeland Security Research Consortium
  • Executive Committee, University Center for Disaster Preparedness and Emergency Response
  • Director, Rutgers University CounterACT Research Center of Excellence

Recent Publications

  1. Mishin, V, Heck, DE, Jan, YH, Richardson, JR, Laskin, JD. Distinct effects of form selective cytochrome P450 inhibitors on cytochrome P450-mediated monooxygenase and hydrogen peroxide generating NADPH oxidase. Toxicol Appl Pharmacol. 2022;455 :116258. doi: 10.1016/j.taap.2022.116258. PubMed PMID:36174671
  2. Sunil, VR, Vayas, KN, Radbel, J, Abramova, E, Gow, A, Laskin, JD, Laskin, DL. Impaired energy metabolism and altered functional activity of alveolar type II epithelial cells following exposure of rats to nitrogen mustard. Toxicol Appl Pharmacol. 2022;456 :116257. doi: 10.1016/j.taap.2022.116257. PubMed PMID:36174670
  3. Murray, A, Banota, T, Guo, GL, Smith, LC, Meshanni, JA, Lee, J, Kong, B, Abramova, EV, Goedken, M, Gow, AJ et al.. Farnesoid X receptor regulates lung macrophage activation and injury following nitrogen mustard exposure. Toxicol Appl Pharmacol. 2022;454 :116208. doi: 10.1016/j.taap.2022.116208. PubMed PMID:35998709
  4. Joseph, LB, Gordon, MK, Zhou, P, Hahn, RA, Lababidi, H, Croutch, CR, Sinko, PJ, Heck, DE, Laskin, DL, Laskin, JD et al.. Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix. Exp Mol Pathol. 2022;128 :104807. doi: 10.1016/j.yexmp.2022.104807. PubMed PMID:35798063
  5. Jan, YH, Heck, DE, An, Y, Laskin, DL, Laskin, JD. Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022;35 (4):636-650. doi: 10.1021/acs.chemrestox.1c00420. PubMed PMID:35312310 PubMed Central PMC9491701
  6. Carnino, JM, Lee, H, Smith, LC, Sunil, VR, Rancourt, RC, Vayas, K, Cervelli, J, Kwok, ZH, Ni, K, Laskin, JD et al.. Microvesicle-Derived miRNAs Regulate Proinflammatory Macrophage Activation in the Lung Following Ozone Exposure. Toxicol Sci. 2022;187 (1):162-174. doi: 10.1093/toxsci/kfac025. PubMed PMID:35201360 PubMed Central PMC9041552
  7. Malaviya, R, Bellomo, A, Abramova, E, Croutch, CR, Roseman, J, Tuttle, R, Peters, E, Casillas, RP, Sunil, VR, Laskin, JD et al.. Pulmonary injury and oxidative stress in rats induced by inhaled sulfur mustard is ameliorated by anti-tumor necrosis factor-α antibody. Toxicol Appl Pharmacol. 2021;428 :115677. doi: 10.1016/j.taap.2021.115677. PubMed PMID:34390737 PubMed Central PMC8452183
  8. Joseph, LB, Gordon, MK, Kang, J, Croutch, CR, Zhou, P, Heck, DE, Laskin, DL, Laskin, JD. Characterization of the rabbit conjunctiva: Effects of sulfur mustard. Exp Mol Pathol. 2021;121 :104656. doi: 10.1016/j.yexmp.2021.104656. PubMed PMID:34081961 PubMed Central PMC9006340
  9. Sandhu, SK, Kumar, S, Raut, J, Singh, M, Kaur, S, Sharma, G, Roldan, TL, Trehan, S, Holloway, J, Wahler, G et al.. Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing. Antioxidants (Basel). 2021;10 (5):. doi: 10.3390/antiox10050725. PubMed PMID:34063003 PubMed Central PMC8148018
  10. Venosa, A, Smith, LC, Gow, AJ, Zarbl, H, Laskin, JD, Laskin, DL. Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression. Toxicol Appl Pharmacol. 2021;423 :115569. doi: 10.1016/j.taap.2021.115569. PubMed PMID:33971176 PubMed Central PMC8496734
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