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Jeffrey D Laskin Ph.D.

Distinguished Professor & Director, Division of Toxicology Environmental and Occupational Health Sciences InstituteEOHSI – Toxicology
Work EOHSI Room 441 170 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-0170
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Biographical Info

Distinguished Professor
Department of Environmental & Occupational Health
Environmental and Occupational Health Sciences Institute
Rutgers University School of Public Health, Piscataway, NJ

Director of the Division of Toxicology
Environmental and Occupational Health Sciences Institute (EOHSI)
Rutgers University School of Public Health, Piscataway, NJ

Director
Rutgers University CounterACT Research Center of Excellence
Rutgers University School of Public Health, Piscataway, NJ

 

Research Areas

Dr. Jeffrey D. Laskin is a Distinguished Professor in the School of Public Health at Rutgers University.  He is Director of the Division of Toxicology at the Environmental and Occupational Health Sciences Institute (EOHSI) and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. He is Director of the Rutgers University CounterACT Research Center of Excellence, a major research effort to develop the most promising scientific discoveries that lead to improved medical countermeasures to protect Americans against a chemical attack.

Dr. Laskin received a B.A. in Chemistry and Biology from New York University, NY and a Ph.D. in Experimental Therapeutics from Roswell Park Cancer Institute, SUNY at Buffalo, NY. He was a post-doctoral fellow in the Institute for Cancer Research at the College of Physicians and Surgeons at Columbia University in NY before joining the faculty the Robert Wood Johnson Medical School and the School of Public Health at Rutgers University. Dr. Laskin has served on numerous study sections for the National Institutes of Health and was an invited participant at the National Institutes of Arthritis and Musculoskeletal Disorders Roundtable on Wound Healing. He is a member of the Cancer Institute of New Jersey, the Graduate School of Biomedical Sciences at Rutgers University and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. Dr. Laskin has also served as a member of the corporation of the Marine Biological Laboratory in Woods Hole, Massachusetts.

Dr. Laskin has served as a reviewer on over 30 journals that deal with pharmacology, toxicology and cancer research. With over 250 peer-reviewed publications, three books, and numerous book chapters and editorials, he has been recognized as one of the most cited scientists in the field of chemical toxicology. His research focuses on mechanisms of chemical-induced skin, lung and liver toxicity. He is an expert in mechanisms of chemical toxicity, phototoxicology and redox chemistry. Dr. Laskin has been continuously funded by the NIH for the last 35 years and has served as PI on numerous RO1’s, as a Program Project PI and as a Center Director. Currently, he is completing research on exposure and health effects of chemical warfare agents and is working to identify countermeasures to sulfur mustard exposure.

Research Highlights

  • Demonstrated that sulfur mustard induces autophagy in the skin
  • Developed models for sulfur mustard-induced skin and lung toxicity
  • Synthesized >100 inhibitors of chemical-induced skin and lung injury
  • Demonstrated that UVB light is an inducer of prostaglandin and leukotriene biosynthetic enzymes

Scholarly Activities

  • Founder, New Jersey Basic and Applied Dermatology Forum
  • NASA, Issues in Advanced Environmental Health and Advanced Food Technology
  • NIH grant reviewer
  • Member, Cancer Institute of New Jersey
  • Member, NJ Department of Homeland Security Preparedness College
  • Executive Committee, NJ Universities Homeland Security Research Consortium
  • Executive Committee, University Center for Disaster Preparedness and Emergency Response
  • Director, Rutgers University CounterACT Research Center of Excellence

Recent Publications

  1. Joseph, LB, Gordon, MK, Kang, J, Croutch, CR, Zhou, P, Heck, DE, Laskin, DL, Laskin, JD. Characterization of the rabbit conjunctiva: Effects of sulfur mustard. Exp Mol Pathol. 2021;121 :104656. doi: 10.1016/j.yexmp.2021.104656. PubMed PMID:34081961
  2. Sandhu, SK, Kumar, S, Raut, J, Singh, M, Kaur, S, Sharma, G, Roldan, TL, Trehan, S, Holloway, J, Wahler, G et al.. Systematic Development and Characterization of Novel, High Drug-Loaded, Photostable, Curcumin Solid Lipid Nanoparticle Hydrogel for Wound Healing. Antioxidants (Basel). 2021;10 (5):. doi: 10.3390/antiox10050725. PubMed PMID:34063003 PubMed Central PMC8148018
  3. Venosa, A, Smith, LC, Gow, AJ, Zarbl, H, Laskin, JD, Laskin, DL. Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression. Toxicol Appl Pharmacol. 2021;423 :115569. doi: 10.1016/j.taap.2021.115569. PubMed PMID:33971176
  4. Murray, A, Gow, AJ, Venosa, A, Andres, J, Malaviya, R, Adler, D, Yurkow, E, Laskin, JD, Laskin, DL. Assessment of mustard vesicant lung injury and anti-TNF-α efficacy in rodents using live-animal imaging. Ann N Y Acad Sci. 2020;1480 (1):246-256. doi: 10.1111/nyas.14525. PubMed PMID:33165947 PubMed Central PMC7968421
  5. Malaviya, R, Kipen, HM, Businaro, R, Laskin, JD, Laskin, DL. Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms. Toxicol Appl Pharmacol. 2020;409 :115272. doi: 10.1016/j.taap.2020.115272. PubMed PMID:33031836
  6. Malaviya, R, Abramova, EV, Rancourt, RC, Sunil, VR, Napierala, M, Weinstock, D, Croutch, CR, Roseman, J, Tuttle, R, Peters, E et al.. Progressive Lung Injury, Inflammation, and Fibrosis in Rats Following Inhalation of Sulfur Mustard. Toxicol Sci. 2020;178 (2):358-374. doi: 10.1093/toxsci/kfaa150. PubMed PMID:33002157 PubMed Central PMC7751178
  7. Francis, M, Guo, G, Kong, B, Abramova, EV, Cervelli, JA, Gow, AJ, Laskin, JD, Laskin, DL. Regulation of Lung Macrophage Activation and Oxidative Stress Following Ozone Exposure by Farnesoid X Receptor. Toxicol Sci. 2020;177 (2):441-453. doi: 10.1093/toxsci/kfaa111. PubMed PMID:32984886 PubMed Central PMC7548292
  8. Mishin, V, Heck, DE, Laskin, DL, Laskin, JD. The amplex red/horseradish peroxidase assay requires superoxide dismutase to measure hydrogen peroxide in the presence of NAD(P)H. Free Radic Res. 2020;54 (8-9):620-628. doi: 10.1080/10715762.2020.1821883. PubMed PMID:32912004 PubMed Central PMC7874521
  9. Herbert, J, Laskin, DL, Gow, AJ, Laskin, JD. Chemical warfare agent research in precision-cut tissue slices-a useful alternative approach. Ann N Y Acad Sci. 2020;1480 (1):44-53. doi: 10.1111/nyas.14459. PubMed PMID:32808309
  10. Smith, LC, Venosa, A, Gow, AJ, Laskin, JD, Laskin, DL. Transcriptional profiling of lung macrophages during pulmonary injury induced by nitrogen mustard. Ann N Y Acad Sci. 2020;1480 (1):146-154. doi: 10.1111/nyas.14444. PubMed PMID:32767459 PubMed Central PMC7901013
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