EOHSI

Biographical Info

Research Areas

• Controlled human exposure health effects studies, incorporating chemical exposures and psychological stress to model realistic environmental exposures.
• Epidemiologic investigations of toxic encephalopathy among workers chronically exposed to solvents and lead with a focus on integrating neuropsychological testing, exposure assessment, and functional imaging.
• Translational research to examine whether alteration in HPA axis function among lead exposed animals translates to humans chronically exposed to lead
• International studies based in Thailand to investigate the cognitive and behavioral effects of pesticide exposure in a birth cohort

Research Highlights

• Discovered a negative dose response relationship between lifetime solvent exposure and functional imaging activation patterns during performance of a working memory task.
• Demonstrated neurobehavioral performance deficits among workers chronically exposed to solvents
• Validated a lifetime solvent exposure index with neurobehavioral performance among workers chronically exposed to solvent mixtures
• Current blood and bone lead alters hypothalamic pituitary adrenal axis function among workers with lifetime exposure
• Developing behavioral research capacity among public health students at Chulalongkorn University, Bangkok, Thailand.

Scholarly Activities

• Member of the Joint Graduate Program in Toxicology, Rutgers University
• NIH Fogarty International Center Grant reviewer
• Co-Chair for the New Jersey Alliance for Clinical and Translational Science Scientific Review Board
• New Jersey Kids Study Co-Chair for neurodevelopmental assessment
• EOHSI representative for the RBHS Mentor Committee
• Chair for the EOHSI Faculty Search Committee

Recent Publications

Click here for additiional publications by Dr. Fiedler.

1. Wang, Y, Hermetz, K, Burt, A, Lesseur, C, Panuwet, P, Fiedler, N, Prapamontol, T, Suttiwan, P, Nimmapirat, P, Sittiwang, S et al.. Prenatal Exposure of Pesticide Mixtures and the Placental Transcriptome: Insights from Trimester-specific, Sex-Specific and Metabolite-Scaled Analyses in the SAWASDEE Cohort. Environ Res. 2024; :120637. doi: 10.1016/j.envres.2024.120637. PubMed PMID:39675449
2. Eick, SM, Sehgal, N, Salamova, A, Fiedler, N, Hood, RB, Yakimavets, V, Promkam, N, Prapamontol, T, Suttiwan, P, Sittiwang, S et al.. Per- and polyfluoroalkyl substances in paired serum and breastmilk samples among pregnant farmworkers in Thailand. Int J Hyg Environ Health. 2024;264 :114509. doi: 10.1016/j.ijheh.2024.114509. PubMed PMID:39647432
3. Gigliotti, RA, Weidner, M, Jansen, M, Greenberg, P, Bachmann, G, Dominguez-Bello, MG, Parmar, V, Panettieri, RA Jr, Reilly, N, Ayers, CA et al.. Assessments of working group effectiveness in the planning of the New Jersey Kids Study: An applied mixed-methods study on the science of team science. J Clin Transl Sci. 2024;8 (1):e163. doi: 10.1017/cts.2024.578. PubMed PMID:39619065 PubMed Central PMC11604504
4. Lu, FT, Gupta, D, Fiedler, N, Satish, U, Black, KG, Legard, A, De Resende, A, Guo, C, Gow, AJ, Kipen, HM et al.. Mechanisms Underlying Acute Cognitive Impairment following Carbon Dioxide Inhalation in a Randomized Crossover Trial. Environ Health Perspect. 2024;132 (10):107702. doi: 10.1289/EHP14806. PubMed PMID:39466336 PubMed Central PMC11515854
5. Fiedler, N, Ohman-Strickland, P, Shen, JD, Black, K, Horton, DB, Panettieri, R Jr, Blaser, MJ, Carson, J, Bendinskas, K, Cheng, H et al.. Age and Hair Cortisol Levels as Predictors of SARS-CoV-2 Infection. Int J Environ Res Public Health. 2024;21 (9):. doi: 10.3390/ijerph21091166. PubMed PMID:39338049 PubMed Central PMC11430878
6. Wang, S, Hicks, MH, Barrett, E, Martsenkovskyi, D, Holovanova, I, Marchak, O, Ishchenko, L, Fiedler, N, Haque, U. Sleep Duration, Insomnia, and Associated Factors Among Ukrainians 1 Year After Russia's Full-Scale Invasion. Psychosom Med. 2024;86 (8):690-699. doi: 10.1097/PSY.0000000000001337. PubMed PMID:39132939
7. Wang, S, Barrett, E, Hicks, MH, Martsenkovskyi, D, Holovanova, I, Marchak, O, Ishchenko, L, Haque, U, Fiedler, N. Associations between mental health symptoms, trauma, quality of life and coping in adults living in Ukraine: A cross-sectional study a year after the 2022 Russian invasion. Psychiatry Res. 2024;339 :116056. doi: 10.1016/j.psychres.2024.116056. PubMed PMID:38968918
8. Haque, U, Bukhari, MH, Fiedler, N, Wang, S, Korzh, O, Espinoza, J, Ahmad, M, Holovanova, I, Chumachenko, T, Marchak, O et al.. A Comparison of Ukrainian Hospital Services and Functions Before and During the Russia-Ukraine War. JAMA Health Forum. 2024;5 (5):e240901. doi: 10.1001/jamahealthforum.2024.0901. PubMed PMID:38758566 PubMed Central PMC11102023
9. Wang, Y, Hermetz, K, Burt, A, Kennedy, EM, Lesseur, C, Panuwet, P, Fiedler, N, Prapamontol, T, Suttiwan, P, Naksen, W et al.. Placental transcriptome variation associated with season, location, and urinary prenatal pyrethroid metabolites of Thai farm-working women. Environ Pollut. 2024;349 :123873. doi: 10.1016/j.envpol.2024.123873. PubMed PMID:38554839 PubMed Central PMC11070292
10. Dang, T, Sehgal, N, Barr, DB, Panuwet, P, Liang, D, Smarr, M, Naksen, W, Fiedler, N, Promkam, N, Prapamontol, T et al.. Association of prenatal chlorpyrifos exposure with sexually dimorphic differences in anogenital distance among Thai farmworker children. Environ Res. 2024;248 :118325. doi: 10.1016/j.envres.2024.118325. PubMed PMID:38286251 PubMed Central PMC11023773