Biographical Info

Education

• BSc,  (Hons)  University of Edinburgh, Edinburgh, Scotland, UK
• MEd,  Temple University, Philadelphia, PA
• PhD, Temple University, Philadelphia, PA
• Post-Doc, University of Pennsylvania, Philadelphia, PA

Research Areas

Mechanisms of nitric oxide signaling in a wide variety of pathophysiological conditions; molecular mechanisms involved in controlling nitric oxide signaling and the role of nitric oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes; Nitric oxide in inflammatory cells such as macrophages and microglia.

Research

Our laboratory investigates mechanisms of Nitric Oxide signaling in a wide variety of pathophysiological conditions.  We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism.  In particular, we investigate the role of Nitric Oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes.  We are particularly interested in the function of Nitric Oxide in inflammatory cells such as macrophages and microglia.  It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted.

Research Highlights

• S-nitrosylation of pulmonary collectins
• Role of nitric oxide in lung disease
• Mechanisms regulating nitric oxide biosynthesis

Scholarly Activities

• 2001, Florence R.C. Murray Fellowship
• 2000, Translational Medicine Award, Duke University
• 1998, Chartered Chemist, Royal Society of Chemistry
• 1997, Young Investigator Award, International Nitric Oxide Society
• 1996, Young Investigator Award, Oxygen Society
• 1995-97, National Research Service Award, National Institutes of Health-NHLBI in Lung Cell and Molecular Biology
• 1993-95, Russell Conwell Research Fellowship

Recent Publications

1. Smith, LC, Abramova, H, Vayas, K, Rodriguez, J, Gelfand-Titiyevksiy, B, Roepke, T, Laskin, JD, Gow, AJ, Laskin, DL. Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation. Toxicol Sci. 2024; :. doi: 10.1093/toxsci/kfae081. PubMed PMID:38897669
2. Radbel, J, Meshanni, JA, Vayas, KN, Le-Hoang, O, Abramova, E, Zhou, P, Joseph, LB, Laskin, JD, Gow, AJ, Laskin, DL et al.. Effects of ozone exposure on lung injury, inflammation, and oxidative stress in a murine model of non-pneumonic endotoxemia. Toxicol Sci. 2024; :. doi: 10.1093/toxsci/kfae062. PubMed PMID:38749002
3. Bellomo, A, Herbert, J, Kudlak, MJ, Laskin, JD, Gow, AJ, Laskin, DL. Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices. Toxicol Appl Pharmacol. 2024;486 :116941. doi: 10.1016/j.taap.2024.116941. PubMed PMID:38677601
4. Malaviya, R, Meshanni, JA, Sunil, VR, Venosa, A, Guo, C, Abramova, EV, Vayas, KN, Jiang, C, Cervelli, JA, Gow, AJ et al.. Role of macrophage bioenergetics in N-acetylcysteine-mediated mitigation of lung injury and oxidative stress induced by nitrogen mustard. Toxicol Appl Pharmacol. 2024;485 :116908. doi: 10.1016/j.taap.2024.116908. PubMed PMID:38513841
5. Malin, SK, Remchak, ME, Heiston, EM, Battillo, DJ, Gow, AJ, Shah, AM, Liu, Z. Intermediate versus morning chronotype has lower vascular insulin sensitivity in adults with obesity. Diabetes Obes Metab. 2024;26 (5):1582-1592. doi: 10.1111/dom.15456. PubMed PMID:38246697 PubMed Central PMC11001524
6. Gutierrez, B, Aggarwal, T, Erguven, H, Stone, MRL, Guo, C, Bellomo, A, Abramova, E, Stevenson, ER, Laskin, DL, Gow, AJ et al.. Direct assessment of nitrative stress in lipid environments: Applications of a designer lipid-based biosensor for peroxynitrite. iScience. 2023;26 (12):108567. doi: 10.1016/j.isci.2023.108567. PubMed PMID:38144454 PubMed Central PMC10746523
7. Remchak, ME, Dosik, JK, Pappas, G, Gow, AJ, Shah, AM, Malin, SK. Exercise blood pressure and heart rate responses to graded exercise testing in intermediate versus morning chronotypes with obesity. Am J Physiol Heart Circ Physiol. 2023;325 (4):H635-H644. doi: 10.1152/ajpheart.00149.2023. PubMed PMID:37505468 PubMed Central PMC10642995
8. Smith, LC, Gow, AJ, Abramova, E, Vayas, K, Guo, C, Noto, J, Lyman, J, Rodriquez, J, Gelfand-Titiyevskiy, B, Malcolm, C et al.. Role of PPARγ in dyslipidemia and altered pulmonary functioning in mice following ozone exposure. Toxicol Sci. 2023;194 (1):109-119. doi: 10.1093/toxsci/kfad048. PubMed PMID:37202362 PubMed Central PMC10306402
9. Meshanni, JA, Lee, JM, Vayas, KN, Sun, R, Jiang, C, Guo, GL, Gow, AJ, Laskin, JD, Laskin, DL. Suppression of Lung Oxidative Stress, Inflammation, and Fibrosis following Nitrogen Mustard Exposure by the Selective Farnesoid X Receptor Agonist Obeticholic Acid. J Pharmacol Exp Ther. 2024;388 (2):586-595. doi: 10.1124/jpet.123.001557. PubMed PMID:37188530 PubMed Central PMC10801770
10. Herbert, J, Kelty, JS, Laskin, JD, Laskin, DL, Gow, AJ. Menthol flavoring in e-cigarette condensate causes pulmonary dysfunction and cytotoxicity in precision cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2023;324 (3):L345-L357. doi: 10.1152/ajplung.00222.2022. PubMed PMID:36692165 PubMed Central PMC10026991