EOHSI

Education

• BSc,  (Hons)  University of Edinburgh, Edinburgh, Scotland, UK
• MEd,  Temple University, Philadelphia, PA
• PhD, Temple University, Philadelphia, PA
• Post-Doc, University of Pennsylvania, Philadelphia, PA

Research Areas

Mechanisms of nitric oxide signaling in a wide variety of pathophysiological conditions; molecular mechanisms involved in controlling nitric oxide signaling and the role of nitric oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes; Nitric oxide in inflammatory cells such as macrophages and microglia.

Research

Our laboratory investigates mechanisms of Nitric Oxide signaling in a wide variety of pathophysiological conditions.  We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism.  In particular, we investigate the role of Nitric Oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes.  We are particularly interested in the function of Nitric Oxide in inflammatory cells such as macrophages and microglia.  It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted.

Research Highlights

• S-nitrosylation of pulmonary collectins
• Role of nitric oxide in lung disease
• Mechanisms regulating nitric oxide biosynthesis

Scholarly Activities

• 2001, Florence R.C. Murray Fellowship
• 2000, Translational Medicine Award, Duke University
• 1998, Chartered Chemist, Royal Society of Chemistry
• 1997, Young Investigator Award, International Nitric Oxide Society
• 1996, Young Investigator Award, Oxygen Society
• 1995-97, National Research Service Award, National Institutes of Health-NHLBI in Lung Cell and Molecular Biology
• 1993-95, Russell Conwell Research Fellowship

Recent Publications

1. Remchak, ME, Dosik, JK, Pappas, G, Gow, AJ, Shah, AM, Malin, SK. Exercise blood pressure and heart rate responses to graded exercise testing in intermediate versus morning chronotypes with obesity. Am J Physiol Heart Circ Physiol. 2023;325 (4):H635-H644. doi: 10.1152/ajpheart.00149.2023. PubMed PMID:37505468
2. Smith, LC, Gow, AJ, Abramova, E, Vayas, K, Guo, C, Noto, J, Lyman, J, Rodriquez, J, Gelfand-Titiyevskiy, B, Malcolm, C et al.. Role of PPARγ in dyslipidemia and altered pulmonary functioning in mice following ozone exposure. Toxicol Sci. 2023;194 (1):109-119. doi: 10.1093/toxsci/kfad048. PubMed PMID:37202362 PubMed Central PMC10306402
3. Meshanni, JA, Lee, JM, Vayas, KN, Sun, R, Jiang, C, Guo, GL, Gow, AJ, Laskin, JD, Laskin, DL. Suppression of lung oxidative stress, inflammation and fibrosis following nitrogen mustard exposure by the selective farnesoid X receptor agonist obeticholic acid. J Pharmacol Exp Ther. 2023; :. doi: 10.1124/jpet.123.001557. PubMed PMID:37188530
4. Herbert, J, Kelty, JS, Laskin, JD, Laskin, DL, Gow, AJ. Menthol flavoring in e-cigarette condensate causes pulmonary dysfunction and cytotoxicity in precision cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2023;324 (3):L345-L357. doi: 10.1152/ajplung.00222.2022. PubMed PMID:36692165 PubMed Central PMC10026991
5. Malaviya, R, Gardner, CR, Rancourt, RC, Smith, LC, Abramova, EV, Vayas, KN, Gow, AJ, Laskin, JD, Laskin, DL. Lung injury and oxidative stress induced by inhaled chlorine in mice is associated with proinflammatory activation of macrophages and altered bioenergetics. Toxicol Appl Pharmacol. 2023;461 :116388. doi: 10.1016/j.taap.2023.116388. PubMed PMID:36690086 PubMed Central PMC9960611
6. Radbel, J, Meshanni, JA, Gardner, CR, Le-Hoang, O, Cervelli, J, Laskin, JD, Gow, AJ, Laskin, DL. Novel method to assess resident alveolar macrophage efferocytosis of apoptotic neutrophils by flow cytometry. Toxicol Appl Pharmacol. 2023;460 :116359. doi: 10.1016/j.taap.2022.116359. PubMed PMID:36565939 PubMed Central PMC9870943
7. Gholizadeh, A, Black, K, Kipen, H, Laumbach, R, Gow, A, Weisel, C, Javanmard, M. Detection of respiratory inflammation biomarkers in non-processed exhaled breath condensate samples using reduced graphene oxide. RSC Adv. 2022;12 (55):35627-35638. doi: 10.1039/d2ra05764f. PubMed PMID:36545081 PubMed Central PMC9745889
8. Pappas, G, Wilkinson, ML, Gow, AJ. Nitric oxide regulation of cellular metabolism: Adaptive tuning of cellular energy. Nitric Oxide. 2023;131 :8-17. doi: 10.1016/j.niox.2022.11.006. PubMed PMID:36470373 PubMed Central PMC9839556
9. Taylor, S, Murray, A, Francis, M, Abramova, E, Guo, C, Laskin, DL, Gow, AJ. Regulation of macrophage activation by S-Nitrosothiols following ozone-induced lung injury. Toxicol Appl Pharmacol. 2022;457 :116281. doi: 10.1016/j.taap.2022.116281. PubMed PMID:36244437 PubMed Central PMC10250783
10. Xu, S, Karmacharya, N, Woo, J, Cao, G, Guo, C, Gow, A, Panettieri, RA Jr, Jude, JA. Starving a Cell Promotes Airway Smooth Muscle Relaxation: Inhibition of Glycolysis Attenuates Excitation-Contraction Coupling. Am J Respir Cell Mol Biol. 2023;68 (1):39-48. doi: 10.1165/rcmb.2021-0495OC. PubMed PMID:36227725 PubMed Central PMC9817909