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Andrew Gow Ph.D.

Professor Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology
Work William Levine Hall Room 009 160 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 732-445-4612 Work Fax: 732-445-0119
Photo of Andrew Gow Ph.D.

Biographical Info

Education

  • BSc,  (Hons)  University of Edinburgh, Edinburgh, Scotland, UK
  • MEd,  Temple University, Philadelphia, PA
  • PhD, Temple University, Philadelphia, PA
  • Post-Doc, University of Pennsylvania, Philadelphia, PA

Research Areas

Mechanisms of nitric oxide signaling in a wide variety of pathophysiological conditions; molecular mechanisms involved in controlling nitric oxide signaling and the role of nitric oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes; Nitric oxide in inflammatory cells such as macrophages and microglia.

Research

Our laboratory investigates mechanisms of Nitric Oxide signaling in a wide variety of pathophysiological conditions.  We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism.  In particular, we investigate the role of Nitric Oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes.  We are particularly interested in the function of Nitric Oxide in inflammatory cells such as macrophages and microglia.  It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted.

Research Highlights

  • S-nitrosylation of pulmonary collectins
  • Role of nitric oxide in lung disease
  • Mechanisms regulating nitric oxide biosynthesis

Scholarly Activities

  • 2001, Florence R.C. Murray Fellowship
  • 2000, Translational Medicine Award, Duke University
  • 1998, Chartered Chemist, Royal Society of Chemistry
  • 1997, Young Investigator Award, International Nitric Oxide Society
  • 1996, Young Investigator Award, Oxygen Society
  • 1995-97, National Research Service Award, National Institutes of Health-NHLBI in Lung Cell and Molecular Biology
  • 1993-95, Russell Conwell Research Fellowship

Recent Publications

  1. Parikh, A, Vinnard, C, Fahrenfeld, N, Davidow, AL, Patrawalla, A, Lardizabal, A, Gow, A, Panettieri, R, Gennaro, M. Revisiting John Snow to Meet the Challenge of Nontuberculous Mycobacterial Lung Disease. Int J Environ Res Public Health. 2019;16 (21):. doi: 10.3390/ijerph16214250. PubMed PMID:31683836
  2. Sunil, VR, Vayas, KN, Abramova, EV, Rancourt, R, Cervelli, JA, Malaviya, R, Goedken, M, Venosa, A, Gow, AJ, Laskin, JD et al.. Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard. Toxicol. Appl. Pharmacol. 2019; :114798. doi: 10.1016/j.taap.2019.114798. PubMed PMID:31678244
  3. Venosa, A, Smith, LC, Murray, A, Banota, T, Gow, AJ, Laskin, JD, Laskin, DL. Regulation of Macrophage Foam Cell Formation during Nitrogen Mustard (NM)-Induced Pulmonary Fibrosis by Lung Lipids. Toxicol. Sci. 2019; :. doi: 10.1093/toxsci/kfz187. PubMed PMID:31428777
  4. Guo, CJ, Atochina-Vasserman, EN, Abramova, E, Smith, LC, Beers, MF, Gow, AJ. Surfactant protein-D modulation of pulmonary macrophage phenotype is controlled by S-nitrosylation. Am. J. Physiol. Lung Cell Mol. Physiol. 2019;317 (5):L539-L549. doi: 10.1152/ajplung.00506.2018. PubMed PMID:31411060
  5. Maisel, K, Merrilees, MJ, Atochina-Vasserman, EN, Lian, L, Obraztsova, K, Rue, R, Vasserman, AN, Zuo, N, Angel, LF, Gow, AJ et al.. Immune Checkpoint Ligand PD-L1 Is Upregulated in Pulmonary Lymphangioleiomyomatosis. Am. J. Respir. Cell Mol. Biol. 2018;59 (6):723-732. doi: 10.1165/rcmb.2018-0123OC. PubMed PMID:30095976 PubMed Central PMC6293078
  6. Sunil, VR, Vayas, KN, Cervelli, JA, Ebramova, EV, Gow, AJ, Goedken, M, Malaviya, R, Laskin, JD, Laskin, DL. Protective Role of Surfactant Protein-D Against Lung Injury and Oxidative Stress Induced by Nitrogen Mustard. Toxicol. Sci. 2018;166 (1):108-122. doi: 10.1093/toxsci/kfy188. PubMed PMID:30060251 PubMed Central PMC6204765
  7. Woessner, M, VanBruggen, MD, Pieper, CF, Sloane, R, Kraus, WE, Gow, AJ, Allen, JD. Beet the Best?. Circ. Res. 2018;123 (6):654-659. doi: 10.1161/CIRCRESAHA.118.313131. PubMed PMID:29976553 PubMed Central PMC6202165
  8. Gusliakova, O, Atochina-Vasserman, EN, Sindeeva, O, Sindeev, S, Pinyaev, S, Pyataev, N, Revin, V, Sukhorukov, GB, Gorin, D, Gow, AJ et al.. Use of Submicron Vaterite Particles Serves as an Effective Delivery Vehicle to the Respiratory Portion of the Lung. Front Pharmacol. 2018;9 :559. doi: 10.3389/fphar.2018.00559. PubMed PMID:29915536 PubMed Central PMC5994594
  9. Botelho, D, Leo, BF, Massa, C, Sarkar, S, Tetley, T, Chung, KF, Chen, S, Ryan, MP, Porter, A, Atochina-Vasserman, EN et al.. Exposure to Silver Nanospheres Leads to Altered Respiratory Mechanics and Delayed Immune Response in an in Vivo Murine Model. Front Pharmacol. 2018;9 :213. doi: 10.3389/fphar.2018.00213. PubMed PMID:29632485 PubMed Central PMC5879457
  10. Vinod, S, Gow, A, Weinberger, B, Potak, D, Hiatt, M, Chandra, S, Hegyi, T. Serum surfactant protein D as a marker for bronchopulmonary dysplasia. J. Matern. Fetal. Neonatal. Med. 2019;32 (5):815-819. doi: 10.1080/14767058.2017.1392506. PubMed PMID:29025303
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