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Andrew Gow, Ph.D.

Professor Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology
Work William Levine Hall Room 009 160 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 732-445-4612 Work Fax: 732-445-0119
Photo of Andrew Gow Ph.D.

Biographical Info

Education

  • BSc,  (Hons)  University of Edinburgh, Edinburgh, Scotland, UK
  • MEd,  Temple University, Philadelphia, PA
  • PhD, Temple University, Philadelphia, PA
  • Post-Doc, University of Pennsylvania, Philadelphia, PA

Research Areas

Mechanisms of nitric oxide signaling in a wide variety of pathophysiological conditions; molecular mechanisms involved in controlling nitric oxide signaling and the role of nitric oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes; Nitric oxide in inflammatory cells such as macrophages and microglia.

Research

Our laboratory investigates mechanisms of Nitric Oxide signaling in a wide variety of pathophysiological conditions.  We seek to understand the molecular mechanisms involved in controlling Nitric Oxide signaling and answer the question as to how nature uses such a simple molecule to control a multitude of biological processes and in almost every organism.  In particular, we investigate the role of Nitric Oxide in cardiopulmonary diseases such as emphysema, acute lung injury, bronchopulmonary dysplasia, sickle cell disease and diabetes.  We are particularly interested in the function of Nitric Oxide in inflammatory cells such as macrophages and microglia.  It is thought that by better understanding the mechanisms involved in Nitric Oxide signaling that we can design appropriate pharmacological interventions for human diseases in which Nitric Oxide metabolism is disrupted.

Research Highlights

  • S-nitrosylation of pulmonary collectins
  • Role of nitric oxide in lung disease
  • Mechanisms regulating nitric oxide biosynthesis

Scholarly Activities

  • 2001, Florence R.C. Murray Fellowship
  • 2000, Translational Medicine Award, Duke University
  • 1998, Chartered Chemist, Royal Society of Chemistry
  • 1997, Young Investigator Award, International Nitric Oxide Society
  • 1996, Young Investigator Award, Oxygen Society
  • 1995-97, National Research Service Award, National Institutes of Health-NHLBI in Lung Cell and Molecular Biology
  • 1993-95, Russell Conwell Research Fellowship

Recent Publications

  1. Golden, T, Murray, A, Venosa, A, Gow, AJ. Comprehensive dataset to assess morphological changes subsequent to bleomycin exposure. Data Brief. 2021;37 :107270. doi: 10.1016/j.dib.2021.107270. PubMed PMID:34430679 PubMed Central PMC8365314
  2. Massa, CM, Liu, Z, Taylor, S, Pettit, AP, Stakheyeva, MN, Korotkova, E, Popova, V, Atochina-Vasserman, EN, Gow, AJ. Biological Mechanisms of S-Nitrosothiol Formation and Degradation: How Is Specificity of S-Nitrosylation Achieved?. Antioxidants (Basel). 2021;10 (7):. doi: 10.3390/antiox10071111. PubMed PMID:34356344 PubMed Central PMC8301044
  3. Venosa, A, Smith, LC, Gow, AJ, Zarbl, H, Laskin, JD, Laskin, DL. Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression. Toxicol Appl Pharmacol. 2021;423 :115569. doi: 10.1016/j.taap.2021.115569. PubMed PMID:33971176 PubMed Central PMC8496734
  4. Venosa, A, Gow, JG, Taylor, S, Golden, TN, Murray, A, Abramova, E, Malaviya, R, Laskin, DL, Gow, AJ. Myeloid cell dynamics in bleomycin-induced pulmonary injury in mice; effects of anti-TNFα antibody. Toxicol Appl Pharmacol. 2021;417 :115470. doi: 10.1016/j.taap.2021.115470. PubMed PMID:33647319
  5. Murray, A, Gow, AJ, Venosa, A, Andres, J, Malaviya, R, Adler, D, Yurkow, E, Laskin, JD, Laskin, DL. Assessment of mustard vesicant lung injury and anti-TNF-α efficacy in rodents using live-animal imaging. Ann N Y Acad Sci. 2020;1480 (1):246-256. doi: 10.1111/nyas.14525. PubMed PMID:33165947 PubMed Central PMC7968421
  6. Francis, M, Guo, G, Kong, B, Abramova, EV, Cervelli, JA, Gow, AJ, Laskin, JD, Laskin, DL. Regulation of Lung Macrophage Activation and Oxidative Stress Following Ozone Exposure by Farnesoid X Receptor. Toxicol Sci. 2020;177 (2):441-453. doi: 10.1093/toxsci/kfaa111. PubMed PMID:32984886 PubMed Central PMC7548292
  7. Wilkinson, ML, Abramova, E, Guo, C, Gow, JG, Murray, A, Koudelka, A, Cechova, V, Freeman, BA, Gow, AJ. Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury. Toxicol Appl Pharmacol. 2020;407 :115236. doi: 10.1016/j.taap.2020.115236. PubMed PMID:32931793 PubMed Central PMC7662837
  8. Herbert, J, Laskin, DL, Gow, AJ, Laskin, JD. Chemical warfare agent research in precision-cut tissue slices-a useful alternative approach. Ann N Y Acad Sci. 2020;1480 (1):44-53. doi: 10.1111/nyas.14459. PubMed PMID:32808309
  9. Smith, LC, Venosa, A, Gow, AJ, Laskin, JD, Laskin, DL. Transcriptional profiling of lung macrophages during pulmonary injury induced by nitrogen mustard. Ann N Y Acad Sci. 2020;1480 (1):146-154. doi: 10.1111/nyas.14444. PubMed PMID:32767459 PubMed Central PMC7901013
  10. Parikh, A, Vinnard, C, Fahrenfeld, N, Davidow, AL, Patrawalla, A, Lardizabal, A, Gow, A, Panettieri, R, Gennaro, M. Revisiting John Snow to Meet the Challenge of Nontuberculous Mycobacterial Lung Disease. Int J Environ Res Public Health. 2019;16 (21):. doi: 10.3390/ijerph16214250. PubMed PMID:31683836 PubMed Central PMC6862550
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Categories: Faculty, Toxicology, Member, Tox Member
Updated 8 months ago.