Associate Professor
Rutgers UniversityEOHSI- Department of Pharmacology and Toxicology – Ernest Mario School of Pharmacy
Work Phone: 848-445-0142 -Officework
Work Phone: 848-445-0113 – Labwork
Work Email: stapleton@eohsi.rutgers.eduINTERNET
Biography
Dr. Stapleton is an Associate Professor within the Department of Pharmacology and Toxicology of the Ernest Mario School of Pharmacy at Rutgers University. She currently serves as the Division Director for Environmental and Population Health Biosciences branch of EOHSI. Dr. Stapleton also serves within the Joint Graduate Program in Toxicology.
She received her B.S. in Biology and Athletic Training from State University of New York (SUNY) College at Cortland, a M.S.Ed. in Kinesiology from Southern Illinois University at Edwardsville, and a Ph.D. in Exercise Physiology from West Virginia University with a focus on microvascular physiology. She completed her postdoctoral training in inhalation nanotoxicology within the Department of Physiology and Pharmacology at West Virginia University.
Research Areas
The microcirculation branch of the cardiovascular system encompasses the arterioles, capillaries, and venules within an organ or tissue of interest. These highly active vessels serve to maintain homeostasis by regulating blood flow and tissue perfusion, thus providing nutrients and removing waste. Central to proper reactivity is the health and function of the endothelium, a single cell layer lining the vasculature. The Stapleton laboratory investigates the microvascular perturbations associated with normal physiological challenges (exercise or pregnancy), disease, and exposures to environmental and/or occupational xenobiotics.
Our overarching research question is: how do particles inhaled during pregnancy affect the pregnant mother, fetal development, and offspring health with a focus on cardiovascular physiology. Within this umbrella, we have assessed exposure to micro- and nanoplastic particles and utilized engineered nanomaterials as a surrogate for ultrafine particulate matter with a keen focus on particle translocation, deposition, and cardiovascular perturbation. Our laboratory was previously supported by the Herbert W. Hoover Foundation and an NIEHS Outstanding New Environmental Scientist Award (ONES; NIH R01 ES031285). Our laboratory is currently supported by R01 ES036575.


Research Highlights
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Inhaled particulate matter during pregnancy, micro- and nanoplastic particles (MNP) and nano-titanium dioxide, differentially impact placental development.
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Inhaled micro- and nanoplastic particles (MNP) aerosols were found to alter inflammatory, cardiovascular, and endocrine activity in virgin female Sprague-Dawley rats.
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Identified and visualized micro- and nanoplastic particles that have translocated from the maternal lungs or GI system to the fetal tissues 24h after pulmonary or gastric exposure, respectively, in late pregnancy.
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Development of a novel placental perfusion technique to quantify material transfer from the maternal uterine circulation to the fetal umbilical circulation and measure biomarkers of uteroplacental function.
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Identified and visualized nanoplastic particles are able to translocate from the maternal lungs to the fetal tissues after pulmonary exposure in late pregnancy.
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Development of a novel intravital microscopy technique to visualize the vasculature of the pregnant uterus.
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Identified microvascular dysfunction and behavioral alterations associated with engineered nanomaterial exposure in gestation.
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Identification of the development of a hostile gestational environment after engineered nanomaterial exposure during pregnancy.
Awards/Recognition
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Dr. Stapleton acted as the Society of Toxicology representative for the annual SOT-EuroTox debate (2026)
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Dr. Chelsea Cary was awarded the Doctoral Student Merit and Achievement Award from the Rutgers School of Graduate Studies (2026)
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Ms. Talia Seymore was an invited Symposium Speaker for the session Battle of the Sexes: Sexually Dimorphic Reponses to In Utero Toxicant Exposures, presenting: “Exposure to Particulate Matter Causes Sex-Specific Effects on Placental Metabolism” at the Society of Toxicology conference (2025)
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Ms. Samantha Adams received 1st place in the Mid-Atlantic SOT Trainee Poster Presentation (2025)
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Ms. Talia Seymore received an NIH New Investigator Travel Award and was a finalist for the Trophoblast Research New Investigator Award, International Federation of Placental Association (IFPA) (2025)
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Dr. Stapleton was awarded the Biomedical and Health Sciences Dean’s Award from the School of Graduate Studies, Rutgers University (2025)
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Ms. Samantha Adams received the competitive Bristol-Myers Squibb Graduate Fellowship (2024-2025)
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Dr. Stapleton was appointed as Chair of the NJ DEP Drinking Water Quality Institute (2024)
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Ms. Talia Seymore placed for the Trophoblast Research New Investigator oral presentation, International Federation of Placental Association (IFPA) (2024)
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Dr. Stapleton was awarded the Society of Toxicology (SOT) Achievement Award (2024)
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Ms. Talia Seymore received 1st place in the Mid-Atlantic SOT Trainee Poster Presentation (2025)
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Laboratory publication,
Ingested polystyrene micro-nanoplastics (MNPs) translate to placenta and fetal tissues in pregnant rats identified as
top 1% of NIEHS papers published in 2023
- Ms. Chelsea Cary awarded the Rutgers School of Graduate Studies Aaron Shatkin Graduate Award (2023)
- Ms. Talia Seymore was a finalist for the Trophoblast Research New Investigator Award, International Federation of Placental Association (IFPA) (2023)
- Ms. Chelsea Cary was awarded a Kirschstein-NRSA (F31-ES035256) pre-doctoral fellowship from NIEHS (2023)
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Ms. Chelsea Cary and Talia Seymore were each awarded a Diversity Initiatives Career Development Award from SOT (2023)
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Dr. Stapleton was awarded the Women in Toxicology (WIT) Outstanding Young Investigator award (2023)
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Ms. Talia Seymore placed 2nd in the poster session for the International Particle Toxicology Conference held in Santa Fe, NM (2022)
- Laboratory publication, Maternal, placental, and fetal distribution of titanium after repeated titanium dioxide nanoparticle inhalation through pregnancy identified as top 1% of NIEHS papers published in 2022
- Mr. Andrés D. Rivera Ruiz was awarded the SOT Undergraduate Diversity Award in 2021 for his work as an 2020 Virtual SURF trainee.
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Dr. Stapleton received the Outstanding New Environmental Scientist (ONES) Award from NIEHS (2021).
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Ms. Chelsea Cary won the Graduate Student Trainee Award from the Cardiovascular Toxicology Specialty Section of the Society of Toxicology (SOT) (2021).
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Dr. Stapleton received the New Career Scientist Award from the Reproductive and Developmental Toxicology Specialty Section of the Society of Toxicology (SOT) (2021).
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Ms. Jeanine D’Errico (King) was awarded the WIT Vera W. Hudson and Elizabeth K Weisburger Student Scholarship Award (2020)
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Dr. Stapleton received the 2020 Young Investigator Award from the Inhalation and Respiratory Toxicology Specialty Section of the Society of Toxicology (SOT).
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Dr. Stapleton and her collaborators were awarded the 2019 Best Paper of the Year, published in Particle and Fibre Toxicology. Their manuscript,
‘Maternal Engineered Nanomaterial Inhalation During Gestation Alters the Fetal Transcriptome’, represents the best cutting-edge research published in the journal. The paper was selected by the journal’s Editorial Board and is scored by its citations, downloads, and impact in the year. This award-winning manuscript can be found
here and more information about the journal Particle and Fibre Toxicology can be found
here.
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Ms. Charlotte Love was awarded a Pfizer SOT Undergraduate Travel Award based on her 2018 SURF fellowship (2019)
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Ms. Jeanine D’Errico (King) was awarded a Bristol-Myers Squibb Summer Internship within the department of Drug Safety and Evaluation within the Molecular Toxicology group (2017)
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