Jeehiun “Katherine” Lee, Ph.D.

Professor Rutgers UniversityEOHSI – Toxicology
Work Wright Rieman Labs Rooms 382/372 610 Taylor Road Piscataway NJ 08854 Work Phone: 732-445-6562
Photo of Jeehiun “Katherine” Lee Ph.D.

Biographical Info

Research Areas

Our laboratory is multi-disciplinary, with projects that range from organic to biological to analytical. Recent projects include: (i) exploring how damaged DNA differs from normal DNA. Mutated bases are linked to carcinogenesis and cell death and it is therefore important to understand how these damaged bases differ from normal bases. In particular, we are interested in how the damaged bases are identified and excised by enzymes; (ii) identification of small RNAs in cell lysates (collaborative project); (iii) studying the properties of silanols, particularly acidity, to characterize their potential as catalysts (collaborative project); (iv) examining the properties and reactivities of N-heterocyclic carbenes, which are a “hot” topic nowadays due to their versatility (as organometallic ligands, organocatalysts, components in environmentally friendly solvents). Our methods include traditional organic tools (including synthesis) as well as spectroscopy (mass spectrometry, UV absorbance, NMR), and computational chemistry.

Recent Publications

  1. Krajewski, AE, Lee, JK. Gas-Phase Experimental and Computational Studies of 5-Halouracils: Intrinsic Properties and Biological Implications. J Org Chem. 2021;86 (9):6361-6370. doi: 10.1021/acs.joc.1c00183. PubMed PMID:33891415
  2. Majumdar, C, McKibbin, PL, Krajewski, AE, Manlove, AH, Lee, JK, David, SS. Unique Hydrogen Bonding of Adenine with the Oxidatively Damaged Base 8-Oxoguanine Enables Specific Recognition and Repair by DNA Glycosylase MutY. J Am Chem Soc. 2020;142 (48):20340-20350. doi: 10.1021/jacs.0c06767. PubMed PMID:33202125
  3. Xu, J, Krajewski, AE, Niu, Y, Kiruba, GSM, Lee, JK. Kinetic hydricity of silane hydrides in the gas phase. Chem Sci. 2019;10 (34):8002-8008. doi: 10.1039/c9sc02118c. PubMed PMID:31853355 PubMed Central PMC6837013
  4. Wang, N, Lee, JK. Gas-Phase and Ionic Liquid Experimental and Computational Studies of Imidazole Acidity and Carbon Dioxide Capture. J Org Chem. 2019;84 (22):14593-14601. doi: 10.1021/acs.joc.9b02193. PubMed PMID:31647232
  5. Xu, J, Mieres-Perez, J, Sanchez-Garcia, E, Lee, JK. Gas-Phase Deprotonation of Benzhydryl Cations: Carbene Basicity, Multiplicity, and Rearrangements. J Org Chem. 2019;84 (12):7685-7693. doi: 10.1021/acs.joc.9b00496. PubMed PMID:31008604
  6. Wang, N, Xu, J, Lee, JK. The importance of N-heterocyclic carbene basicity in organocatalysis. Org Biomol Chem. 2018;16 (37):8230-8244. doi: 10.1039/c8ob01667d. PubMed PMID:30191938
  7. Niu, Y, Wang, N, Muñoz, A, Xu, J, Zeng, H, Rovis, T, Lee, JK. Experimental and Computational Gas Phase Acidities of Conjugate Acids of Triazolylidene Carbenes: Rationalizing Subtle Electronic Effects. J Am Chem Soc. 2017;139 (42):14917-14930. doi: 10.1021/jacs.7b05229. PubMed PMID:29039669 PubMed Central PMC5846624
  8. Kiruba, GS, Xu, J, Zelikson, V, Lee, JK. Gas-Phase Studies of Formamidopyrimidine Glycosylase (Fpg) Substrates. Chemistry. 2016;22 (11):3881-90. doi: 10.1002/chem.201505003. PubMed PMID:26894440
  9. Teator, AJ, Tian, Y, Chen, M, Lee, JK, Bielawski, CW. An Isolable, Photoswitchable N-Heterocyclic Carbene: On-Demand Reversible Ammonia Activation. Angew Chem Int Ed Engl. 2015;54 (39):11559-63. doi: 10.1002/anie.201506269. PubMed PMID:26274507
  10. Tian, Y, Lee, JK. Gas Phase Studies of N-Heterocyclic Carbene-Catalyzed Condensation Reactions. J Org Chem. 2015;80 (13):6831-8. doi: 10.1021/acs.joc.5b01069. PubMed PMID:26066314
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Categories: Faculty, Toxicology

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