Distinguished Professor
Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Work Phone: 848-445-6349work
Work Email: gyou@rci.rutgers.eduINTERNET
Biography
Research Areas
Molecular and Cellular Pharmacology, Drug/Xenobiotic Absorption, Distribution and Elimination, Membrane Transporters
Drug transporters mediate the absorption, distribution, and excretion of a diverse array of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore are critical to the survival of the mammalian species. The goal of Dr. You’s research is to elucidate the molecular, cellular, and functional characteristics of these transporters, their implications in human physiology and diseases, and their applications to drug therapy. Techniques in molecular and cellular biology, physiology, biochemistry, and biophysics are used to investigate the transport mechanisms both in vitro and in vivo. The knowledge gained from these studies will have significant impact on the future design of strategies aimed at maximizing therapeutic efficacy and minimizing toxicity, and will permit insight into the molecular, cellular, and clinical bases of renal, hepatic, neurological and fetal toxicity and disease.
Research Highlights
Dr. You’s lab, standing at the forefront of drug transport research, a research area of highly pharmacological and clinical importance, has uncovered several mechanisms underlying the regulation of drug transporters OATs. Her lab is the first to report that OAT activity can be regulated by membrane trafficking, ubiquitination, glycosylation, phosphorlation, and environmental pH.
Scholarly Activities
- 2012-2014 Co-Editor, Book “Drug Transporters” to be published by Wiley & Son, NY, NY
- 2012-2013 Executive Council, Graduate School-New Brunswick, Rutgers University
- 2011-2012 Co-Chair, Mission, Planning & Evaluation sub-committee, ACPE Steering Committee, School of Pharmacy, Rutgers University
- 2012 NIH Review Panel for COBRE Pilot Project Applications
- 2012 NIH Special Emphasis Review Panel for Program Project Grants.
- 2008-2011 Executive Committee, Student and Postdoc Outreach and Development, American Association of Pharmaceutical Scientists
- 2007-2011 NIH Study Section Permanent Member, Cellular and Molecular Biology of the Kidney
- 2011 NIH Special Emphasis Review Panel for Program Project Grants.
- 2011 Committee, Pharmaceutical Research Meritorious Manuscript Award, Pharmaceutical Research
- 2010 Co-Chair, Symposium “Transport Proteins I: Regulatory Mechanisms That Modulate Drug Disposition and Response”, American Association of Pharmaceutical Scientists, Georgia.
- 2009-present Editorial Board, International Journal of Biochemistry and Molecular Biology
- 2008-2012 Executive Committee, Drug Transport Focus Group, American Association of Pharmaceutical Scientist
- 2006-present Editorial Board, Pharmaceutical Research
Recent Publications
- He, Y, You, G, Zhou, Y, Ai, L, Liu, W, Meng, X, Wu, Q. Integrative Machine Learning of Glioma and Coronary Artery Disease Reveals Key Tumour Immunological Links. J Cell Mol Med. 2025;29 (2):e70377. doi: 10.1111/jcmm.70377. PubMed PMID:39868675 PubMed Central PMC11770474
- Hu, Z, Xu, J, Shen, R, Lin, L, Su, Y, Xie, C, You, G, Zhou, Y, Huang, K. Combination of Biological Aging and Genetic Susceptibility Helps Identifying At-Risk Population of Venous Thromboembolism: A Prospective Cohort Study of 394 041 Participants. Am J Hematol. 2025; :. doi: 10.1002/ajh.27605. PubMed PMID:39840850
- Zheng, L, Yang, Y, Bu, F, Ye, R, Zhang, F, Ji, Z, Zhu, X, Chen, H, Shao, R, Liu, L et al.. Efficacy and safety of consolidative thoracic radiotherapy after first-line chemoimmunotherapy in patients with extensive-stage small-cell lung cancer: a retrospective cohort study. Transl Lung Cancer Res. 2024;13 (12):3675-3691. doi: 10.21037/tlcr-2024-1182. PubMed PMID:39830750 PubMed Central PMC11736601
- Xu, C, Hang, P, Kan, C, Guo, X, Song, X, Xu, C, You, G, Liao, WQ, Zhu, H, Wang, D et al.. Molecular ferroelectric self-assembled interlayer for efficient perovskite solar cells. Nat Commun. 2025;16 (1):835. doi: 10.1038/s41467-025-56182-5. PubMed PMID:39828761 PubMed Central PMC11743605
- Shan, S, Zhou, Y, Xu, C, You, G, Chen, H, Fu, W, Zuo, L, Chen, H. DMSO-Assisted Control Enables Highly Efficient 2D/3D Hybrid Perovskite Solar Cells. Small. 2025; :e2410172. doi: 10.1002/smll.202410172. PubMed PMID:39790054
- Zhang, Y, Hou, J, Gu, Y, Zhu, X, Xia, J, Wu, J, You, G, Yang, Z, Ding, W, Miao, L et al.. Spatiotemporal Variation Assessment and Improved Prediction Of Cyanobacteria Blooms in Lakes Using Improved Machine Learning Model Based on Multivariate Data. Environ Manage. 2025; :. doi: 10.1007/s00267-024-02108-8. PubMed PMID:39775014
- Lee, CH, You, GR, Jo, HG, Jun, CH, Cho, EY, Kim, IH, Choi, SK, Yoon, JH. Albumin-Bilirubin Grade as a Valuable Predictor of Recurrence and Prognosis in Patients with Hepatocellular Carcinoma Following Radiofrequency Ablation. Cancers (Basel). 2024;16 (24):. doi: 10.3390/cancers16244167. PubMed PMID:39766066 PubMed Central PMC11674869
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