Biographical Info

Dr. Guo is an Associate Professor at the Department Pharmacology and Toxicology in the Ernest Mario School of Pharmacy of Rutgers University. She is an adjunct faculty of the Department of Pharmacology, Toxicology and Therapeutics in School of Medicine at the University of Kanas Medical Center.  Dr. Guo obtained her MBBS degree from the West China University of Medical Sciences in 1993 and a PhD degree from the University of Kansas Medical Center in 2001, as well as post-doctoral training at the NCI, NIH in 2004. From 2004-2012, Dr. Guo has served as a faculty at the University of Kansas Medical Center.

Research Areas

Liver is essential for life and liver functions are tightly regulated. Particularly, the impact of intestine on liver homeostasis, function and diseases is significant, but this impact has been less studied. Our group has been focusing on determining the effects of intestine-liver crosstalks on liver metabolism and pathogenesis and the underlying molecular mechanisms, especially following disruption of endogenous homeostasis and exposure to xenobiotic chemicals.

Scholarly Activities

• 2012: Presidential Poster Award, AASLD meeting (2)
• 2011: Presidential Poster Award, AASLD meeting
• 2010: Presidential Poster Award, AASLD meeting
• 2009: Presidential Poster Award, AASLD meeting
• 2009: Post award winner for Annual Liver Center Symposium, University of Kansas Medical Center
• 2007: First place in oral presentation in Annual Cancer Center Symposium, University of Kansas Medical Center
• 2005: BIRCWH/NIH scholar

Recent Publications

1. Taylor, R, Basaly, V, Kong, B, Yang, I, Brinker, AM, Capece, G, Bhattacharya, A, Henry, ZR, Otersen, K, Yang, Z et al.. Effects of Therapeutically Approved Individual Bile Acids on The Development of Metabolic Dysfunction-Associated Steatohepatitis a Low Bile Acid Mouse Model. Toxicol Sci. 2024; :. doi: 10.1093/toxsci/kfae110. PubMed PMID:39302723
2. Burchat, N, Vidola, J, Pfreundschuh, S, Sharma, P, Rizzolo, D, Guo, GL, Sampath, H. Intestinal Stearoyl-CoA Desaturase-1 Regulates Energy Balance via Alterations in Bile Acid Homeostasis. Cell Mol Gastroenterol Hepatol. 2024;18 (6):101403. doi: 10.1016/j.jcmgh.2024.101403. PubMed PMID:39278403 PubMed Central PMC11546130
3. Jin, J, Nguyen, LTG, Wassef, A, Sadek, R, Schmitt, TM, Guo, GL, Rasmussen, TP, Zhong, XB. Correlations of Long Noncoding RNA HNF4A-AS1 Alternative Transcripts with Liver Diseases and Drug Metabolism. Drug Metab Dispos. 2024;52 (11):1345-1355. doi: 10.1124/dmd.124.001873. PubMed PMID:39168525
4. Chow, MD, Otersen, K, Wassef, A, Kong, B, Yamarthy, S, Rizzolo, D, Yang, I, Buckley, B, Lu, A, Crook, N et al.. Effects of intestine-specific deletion of FGF15 on the development of fatty liver disease with vertical sleeve gastrectomy. Hepatol Commun. 2024;8 (6):. doi: 10.1097/HC9.0000000000000444. PubMed PMID:38780301 PubMed Central PMC11124683
5. Jin, J, Nguyen, LTG, Wassef, A, Sadek, R, Schmitt, TM, Guo, GL, Rasmussen, TP, Zhong, XB. Identification and Functional Characterization of Alternative Transcripts of LncRNA HNF1A-AS1 and Their Impacts on Cell Growth, Differentiation, Liver Diseases, and in Response to Drug Induction. Noncoding RNA. 2024;10 (2):. doi: 10.3390/ncrna10020028. PubMed PMID:38668386 PubMed Central PMC11053763
6. Taylor, R, Yang, Z, Henry, Z, Capece, G, Meadows, V, Otersen, K, Basaly, V, Bhattacharya, A, Mera, S, Zhou, P et al.. Characterization of individual bile acids in vivo utilizing a novel low bile acid mouse model. Toxicol Sci. 2024;199 (2):316-331. doi: 10.1093/toxsci/kfae029. PubMed PMID:38526215
7. Yang, X, Wang, J, Chang, CY, Zhou, F, Liu, J, Xu, H, Ibrahim, M, Gomez, M, Guo, GL, Liu, H et al.. Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice. Nat Commun. 2024;15 (1):627. doi: 10.1038/s41467-024-44924-w. PubMed PMID:38245529 PubMed Central PMC10799847
8. Yang, Z, Zarbl, H, Guo, GL. Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism. Mol Pharmacol. 2024;105 (3):179-193. doi: 10.1124/molpharm.123.000831. PubMed PMID:38238100 PubMed Central PMC10877735
9. Bhattacharya, A, Taylor, RE, Guo, GL. In vivo mouse models to study bile acid synthesis and signaling. Hepatobiliary Pancreat Dis Int. 2023;22 (5):466-473. doi: 10.1016/j.hbpd.2023.08.009. PubMed PMID:37620226 PubMed Central PMC10790561
10. Meadows, V, Yang, Z, Basaly, V, Guo, GL. FXR Friend-ChIPs in the Enterohepatic System. Semin Liver Dis. 2023;43 (3):267-278. doi: 10.1055/a-2128-5538. PubMed PMID:37442156 PubMed Central PMC10620036