Phoebe Stapleton Ph.D., A.T.C.Assistant Professor Rutgers University-Ernest Mario School of PharmacyEOHSI- Toxicology
Dr. Stapleton is an Assistant Professor in the Rutgers University, Ernest Mario School of Pharmacy, Department of Pharmacology and Toxicology, and the Joint Graduate Program in Toxicology. She received her B.S. in Biology and Athletic Training from State University of New York (SUNY) College at Cortland, a M.S.Ed. in Kinesiology from Southern Illinois University at Edwardsville, and a Ph.D. in Exercise Physiology from West Virginia University. She completed her postdoctoral training within the Department of Physiology and Pharmacology at West Virginia University.
The microcirculation branch of the cardiovascular system encompasses the arterioles, capillaries, and venules within an organ or tissue of interest. These highly active vessels serve to maintain homeostasis by regulating blood flow and tissue perfusion, thus providing nutrients and removing waste. Central to proper reactivity is the health and function of the endothelium, a single cell layer lining the vasculature. The Stapleton laboratory investigates the microvascular perturbations associated with normal physiological challenges (exercise or pregnancy), disease, and exposures to environmental and/or occupational xenobiotics.
Using engineered nanomaterials, studies focus on the question: how can something we inhale affect the cardiovascular system? Recently, her research group has investigated non-traditional models of exposure by incorporating reproductive toxicology. These studies focus on exposures during pregnancy leading to the development of a hostile gestational environment identified through microvascular evaluations of the mother. These prenatal exposures impact fetal development and may predispose future generations to cardiovascular aberrations. The Stapleton laboratory is funded by NIH K99ES024783.
- Identification of the development of a hostile gestational environment after engineered nanomaterial exposure during pregnancy.
- Development of a novel intravital microscopy technique to visualize the vasculature of the pregnant uterus.
- Investigations of mitochondrial function and bioenergetics in young exposed to xenobiotic matter during gestation.
- Identification of microvascular dysfunction and behavioral alterations associated with engineered nanomaterial exposure in gestation.
- Invited speaker to the NIEHS 50th Anniversary Celebration with SOT titled SOT and NIEHS Past, Present, and Future: 50 Years of Collaboration.
- Past-President of the Allegheny-Erie Regional Chapter of the Society of Toxicology.
- Dr. Stapleton recently published a symposia review of Gestational Nanomaterial Exposures in the Journal of Physiology (2016) 594(8):2161-73. (http://www.ncbi.nlm.nih.gov/pubmed/26332609)
- Dr. Stapleton has been awarded the Impact Award by the Cardiovascular Toxicology Specialty Section of SOT (2016), the Best Publication Award by the Nanotoxicology Specialty Section of SOT (2016), and the Best Postdoctoral Publication Award by the Postdoctoral Assembly of SOT (2014).
- Appointed as Review Editor for Frontiers in Vascular Physiology (2012).
- Engler-Chiurazzi EB, Stapleton PA, Stalnaker JJ, Rambo-Hernandez KE, Sarkar SN, Jun S, Quintana DD, Ren X, Hu Heng, Nurkiewicz TR, McBride CR, Yi J, Simpkins JW. Adult Behavioral Consequences of Prenatal Engineered Nanomaterial Exposure in Rodents. Journal of Toxicology and Environmental Health Part A. 2016; 79(11): 447-52. doi: 10.1080/15287394.2016.1164101.
- Stapleton PA. Gestational xenobiotic exposures: microvascular implications for the past, present, and future. Journal of Physiology. Apr; 594(8): 2161-73, 2016. (invited symposium review) doi: 10.1113/JP270581.
- Stapleton PA, Nichols CE, Yi J, McBride CR, Minarchick VC, Shepherd DL, Hollander JM, Nurkiewicz TR. Microvascular and mitochondrial dysfunction in the female F1 generation after gestational TiO2 nanoparticle exposure. Nanotoxicology. 2015 Nov;9(8): 941-51. doi: 10.3109/17435390.2014.984251.
- Nichols CE, Shepherd DL, Knuckles TL, Thapa D, Stricker JC, Stapleton PA, Minarchick VC, Alway SE, Nurkiewicz TR, Hollander JM. Cardiac and Mitochondrial Dysfunction Following Acute Pulmonary Exposure to Mountaintop Removal Mining Particulate Matter. American Journal of Physiology – Heart and Circulatory Physiology. Dec; 309(12): H2017-30, 2015. doi: 10.1152/ajpheart.00353.2015.
- Stapleton PA, McBride CR, Yi J, Nurkiewicz TR. Uterine microvascular sensitivity to nanomaterial inhalation: an in vivo assessment. Toxicology and Applied Pharmacology. Nov; 288(3): 420-8, 2015. doi: 10.1016/j.taap.2015.08.013
- Stapleton PA, Minarchick VC, Yi J, Engels K, McBride CR, Nurkiewicz TR. Maternal engineered nanomaterial exposure and fetal microvascular function: does the Barker hypothesis apply? Am J Obstet Gynecol. Sep; 209(3): 227.e1-227.e11, 2013. doi: 10.1016/j.ajog.2013.04.036.
- Stapleton PA, Minarchick VC, Cumpston AM, McKinney W, Chen BT, Sager TM, Frazer DG, Mercer RR, Scabilloni J, Andrew M, Castranova V, Nurkiewicz TR. Impairment of coronary arteriolar endothelium-dependent dilation after multiwalled-carbon nanotube inhalation: a time course study. IJMS. Oct; 13: 13781-13803, 2012. doi: 10.3390/ijms131113781.
- Stapleton PA, Minarchick V, Knuckles TL, Nurkiewicz TR. Xenobiotic Particle Exposure and Microvascular Endpoints: A Call to Arms. Microcirculation. Feb; 19(2):126-42, 2012. doi: 10.1111/j.1549-8719.2011.00137.x.