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Grace L. Guo MBBS, Ph.D.

Associate Professor Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Address EOHSI Room 322 170 Frelinghuysen Rd Piscataway NJ 08854 Phone: 848-445-8186 (office) Phone: 848-445-6102 (Lab) Fax: 732-445-4161
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Biographical Info

Dr. Guo is an Associate Professor at the Department Pharmacology and Toxicology in the Ernest Mario School of Pharmacy of Rutgers University. She is an adjunct faculty of the Department of Pharmacology, Toxicology and Therapeutics in School of Medicine at the University of Kanas Medical Center.  Dr. Guo obtained her MBBS degree from the West China University of Medical Sciences in 1993 and a PhD degree from the University of Kansas Medical Center in 2001, as well as post-doctoral training at the NCI, NIH in 2004. From 2004-2012, Dr. Guo has served as a faculty at the University of Kansas Medical Center.

Research Areas

Liver is essential for life and liver functions are tightly regulated. Particularly, the impact of intestine on liver homeostasis, function and diseases is significant, but this impact has been less studied. Our group has been focusing on determining the effects of intestine-liver crosstalks on liver metabolism and pathogenesis and the underlying molecular mechanisms, especially following disruption of endogenous homeostasis and exposure to xenobiotic chemicals.

Scholarly Activities

  • 2012: Presidential Poster Award, AASLD meeting (2)
  • 2011: Presidential Poster Award, AASLD meeting
  • 2010: Presidential Poster Award, AASLD meeting
  • 2009: Presidential Poster Award, AASLD meeting
  • 2009: Post award winner for Annual Liver Center Symposium, University of Kansas Medical Center
  • 2007: First place in oral presentation in Annual Cancer Center Symposium, University of Kansas Medical Center
  • 2005: BIRCWH/NIH scholar

Recent Publications

  1. Guo, GL. Why are females more susceptible to cholestasis-induced liver injury - Could it be LncRNA H19?. Hepatology. 2017; :. doi: 10.1002/hep.29255. PubMed PMID:28508397
  2. Byun, S, Kim, YC, Zhang, Y, Kong, B, Guo, G, Sadoshima, J, Ma, J, Kemper, B, Kemper, JK. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J. 2017; :. doi: 10.15252/embj.201695500. PubMed PMID:28446510
  3. Chow, MD, Lee, YH, Guo, GL. The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Mol. Aspects Med. 2017; :. doi: 10.1016/j.mam.2017.04.004. PubMed PMID:28442273
  4. Guo, G. Endoplasmic Reticulum Stress Emerges as Novel Regulator for Bile Acid Synthesis. Cell Mol Gastroenterol Hepatol. 2017;3 (2):135. doi: 10.1016/j.jcmgh.2016.12.007. PubMed PMID:28275679 PubMed Central PMC5331773
  5. Niu, Y, Xu, M, Slagle, BL, Huang, H, Li, S, Guo, GL, Shi, G, Qin, W, Xie, W. Farnesoid X receptor ablation sensitizes mice to hepatitis b virus X protein-induced hepatocarcinogenesis. Hepatology. 2017;65 (3):893-906. doi: 10.1002/hep.28924. PubMed PMID:28102638 PubMed Central PMC5319891
  6. Moscovitz, JE, Yarmush, G, Herrera-Garcia, G, Guo, GL, Aleksunes, LM. Differential regulation of intestinal efflux transporters by pregnancy in mice. Xenobiotica. 2017; :1-9. doi: 10.1080/00498254.2016.1250292. PubMed PMID:28043194
  7. Sun, R, Yang, N, Kong, B, Cao, B, Feng, D, Yu, X, Ge, C, Huang, J, Shen, J, Wang, P et al.. Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway. Mol. Pharmacol. 2017;91 (2):110-122. doi: 10.1124/mol.116.106617. PubMed PMID:27932556 PubMed Central PMC5267522
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Categories: Faculty, Toxicology