eohsi news and announcements

Dr.  Guo is receiving this award in recognition of her innovative research and development of new technologies that have led to the discovery of fundamental and transformative concepts regarding the effects of intestine-liver crosstalk on liver metabolism and pathogenesis and an understanding of the underlying molecular mechanisms following disruption of homeostasis of bile acids and exposure to xenobiotic chemicals.  

Dr. Guo has dedicated her research career on the molecular mechanisms of regulation of drug metabolism, bile acid signaling and toxicology by nuclear receptors, including FXR, PXR and CAR. She made an important discovery in determining the molecular mechanisms by which xenobiotic nuclear receptors regulate chemical disposition. She is one of the pioneer scientists discovering the importance of intestinal FXR and bile acid signaling in regulating liver functions and disease. Her lab has made several genetically modified mouse models to advance the understanding of human physiology, pathology, pharmacology and toxicology. She has been funded by the NIH and the VA for the last 20 years, published over 140 peer-reviewed papers in pharmacology, toxicology and hepatology journals, mentored many students and fellows, and served on the NIH and VA study sections. Dr. Guo has been actively involved in professional societies to advance the field of toxicology, drug metabolism, and hepatology. This Toxicology Career Award recognizes her research achievement, training of graduate students, and dedicated services to professional societies and research community. Dr. Guo has been a member of ASPET since 2008

Source: ASPET 2024 Award Winners