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Stephan Schwander M.D., Ph.D.

Associate Professor and Director, Center of Global Public Health Rutgers University- School of Public HealthEOHSI – Environmental Health Policy
Work School of Public Health Room 305 683 Hoes Lane Piscataway NJ 08854 Work Phone: 732-235-5405
Photo of Stephan Schwander M.D., Ph.D.

Biographical Info

The primary goal of my translational research is to improve the understanding of environmental effects on human health and human immunity during infections such as with Mycobacterium tuberculosis (M.tb), the bacterium that causes TB. For the past 15 years my lab, in collaboration with others, has spearheaded research on human lung immune responses to M.tb. Our findings helped to establish the concept of compartmentalization of immune responses to the lungs in human pulmonary TB.

Recent studies from my lab with co-investigators at EOHSI and at the University of Southern California (USC), have shown that stimulation of peripheral blood mononuclear cells (PBMC) with diesel exhaust particles (DEPs) alter cytokine production and toll-like receptor-mediated M.tb-specific cell activation pathways. DEPs are major components of aerosolized urban ambient fine particulate matter (PM). We noted that the production of critical M.tb-induced pro-inflammatory cytokines such as IFN-gamma, TNF-alpha, IL-1 beta, and IL-6 was reduced in a DEP dose-dependent manner in PBMC. Furthermore, inhibition of expression of many NF-kB and IFN regulatory signaling pathway target genes was observed upon DEP stimulation in non-infected cells. These data suggest that DEPs downregulate M.tb-induced cytokine and gene expression responses thus significantly compromising antimycobacterial host immune responses.

Research Interests

  • Human antimycobacterial immunity
  • Human lung immunology during mycobacteriumtuberculosis infection and disease
  • Effects of particulate matter on antimycobacterial immunity

Recent Publications

  1. van der Kooi, CJ, Ghali, K, Amptmeijer, D, Schwander, T. Niche differentiation among clones in asexual grass thrips. J. Evol. Biol. 2018; :. doi: 10.1111/jeb.13393. PubMed PMID:30339293
  2. van der Kooi, CJ, Matthey-Doret, C, Schwander, T. Evolution and comparative ecology of parthenogenesis in haplodiploid arthropods. Evol Lett. 2017;1 (6):304-316. doi: 10.1002/evl3.30. PubMed PMID:30283658 PubMed Central PMC6121848
  3. Pande, K, Donatelli, JJ, Malmerberg, E, Foucar, L, Poon, BK, Sutter, M, Botha, S, Basu, S, Bruce Doak, R, Dörner, K et al.. Free-electron laser data for multiple-particle fluctuation scattering analysis. Sci Data. 2018;5 :180201. doi: 10.1038/sdata.2018.201. PubMed PMID:30277481 PubMed Central PMC6167951
  4. Zekavat, SM, Ruotsalainen, S, Handsaker, RE, Alver, M, Bloom, J, Poterba, T, Seed, C, Ernst, J, Chaffin, M, Engreitz, J et al.. Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018;9 (1):3493. doi: 10.1038/s41467-018-05975-y. PubMed PMID:30140049 PubMed Central PMC6107495
  5. Natarajan, P, Peloso, GM, Zekavat, SM, Montasser, M, Ganna, A, Chaffin, M, Khera, AV, Zhou, W, Bloom, JM, Engreitz, JM et al.. Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nat Commun. 2018;9 (1):3391. doi: 10.1038/s41467-018-05747-8. PubMed PMID:30140000 PubMed Central PMC6107638
  6. Son, Y, Wackowski, O, Weisel, C, Schwander, S, Mainelis, G, Delnevo, C, Meng, Q. Evaluation of E-Vapor Nicotine and Nicotyrine Concentrations under Various E-Liquid Compositions, Device Settings, and Vaping Topographies. Chem. Res. Toxicol. 2018;31 (9):861-868. doi: 10.1021/acs.chemrestox.8b00063. PubMed PMID:30080399
  7. Fernández-Rhodes, L, Malinowski, JR, Wang, Y, Tao, R, Pankratz, N, Jeff, JM, Yoneyama, S, Carty, CL, Setiawan, VW, Le Marchand, L et al.. The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis. PLoS ONE. 2018;13 (7):e0200486. doi: 10.1371/journal.pone.0200486. PubMed PMID:30044860 PubMed Central PMC6059436
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Categories: Faculty, Environmental Health Policy
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