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Stephan Schwander M.D., Ph.D.

Associate Professor and Director, Center of Global Public Health Rutgers University- School of Public HealthEOHSI – Environmental Health Policy
Address School of Public Health Room 305 683 Hoes Lane Piscataway NJ 08854 Phone: 732-235-5405
Photo of Stephan Schwander M.D., Ph.D.

Biographical Info

The primary goal of my translational research is to improve the understanding of environmental effects on human health and human immunity during infections such as with Mycobacterium tuberculosis (M.tb), the bacterium that causes TB. For the past 15 years my lab, in collaboration with others, has spearheaded research on human lung immune responses to M.tb. Our findings helped to establish the concept of compartmentalization of immune responses to the lungs in human pulmonary TB.

Recent studies from my lab with co-investigators at EOHSI and at the University of Southern California (USC), have shown that stimulation of peripheral blood mononuclear cells (PBMC) with diesel exhaust particles (DEPs) alter cytokine production and toll-like receptor-mediated M.tb-specific cell activation pathways. DEPs are major components of aerosolized urban ambient fine particulate matter (PM). We noted that the production of critical M.tb-induced pro-inflammatory cytokines such as IFN-gamma, TNF-alpha, IL-1 beta, and IL-6 was reduced in a DEP dose-dependent manner in PBMC. Furthermore, inhibition of expression of many NF-kB and IFN regulatory signaling pathway target genes was observed upon DEP stimulation in non-infected cells. These data suggest that DEPs downregulate M.tb-induced cytokine and gene expression responses thus significantly compromising antimycobacterial host immune responses.

Research Interests

  • Human antimycobacterial immunity
  • Human lung immunology during mycobacteriumtuberculosis infection and disease
  • Effects of particulate matter on antimycobacterial immunity

Recent Publications

  1. Son, Y, Wackowski, O, Weisel, C, Schwander, S, Mainelis, G, Delnevo, C, Meng, Q. Evaluation of e-vapor nicotine and nicotyrine concentrations under various e-liquid compositions, device settings, and vaping topographies. Chem. Res. Toxicol. 2018; :. doi: 10.1021/acs.chemrestox.8b00063. PubMed PMID:30080399
  2. Son, Y, Osornio-Vargas, ÁR, O'Neill, MS, Hystad, P, Texcalac-Sangrador, JL, Ohman-Strickland, P, Meng, Q, Schwander, S. Land use regression models to assess air pollution exposure in Mexico City using finer spatial and temporal input parameters. Sci. Total Environ. 2018;639 :40-48. doi: 10.1016/j.scitotenv.2018.05.144. PubMed PMID:29778680
  3. Ellis, T, Chiappi, M, García-Trenco, A, Al-Ejji, M, Sarkar, S, Georgiou, TK, Shaffer, MSP, Tetley, TD, Schwander, S, Ryan, MP et al.. Multimetallic Microparticles Increase the Potency of Rifampicin against Intracellular Mycobacterium tuberculosis. ACS Nano. 2018; :. doi: 10.1021/acsnano.7b08264. PubMed PMID:29767993
  4. Botelho, D, Leo, BF, Massa, C, Sarkar, S, Tetley, T, Chung, KF, Chen, S, Ryan, MP, Porter, A, Atochina-Vasserman, EN et al.. Exposure to Silver Nanospheres Leads to Altered Respiratory Mechanics and Delayed Immune Response in an in Vivo Murine Model. Front Pharmacol. 2018;9 :213. doi: 10.3389/fphar.2018.00213. PubMed PMID:29632485 PubMed Central PMC5879457
  5. Schwander, S, Keane, J. Cause or Effect? The Elusive Role of Regulatory T Cells in Tuberculosis. Am. J. Respir. Crit. Care Med. 2018;198 (1):11-12. doi: 10.1164/rccm.201802-0233ED. PubMed PMID:29490145
  6. Zhang, JJ, Lee, KB, He, L, Seiffert, J, Subramaniam, P, Yang, L, Chen, S, Maguire, P, Mainelis, G, Schwander, S et al.. Effects of a nanoceria fuel additive on the physicochemical properties of diesel exhaust particles. Environ Sci Process Impacts. 2016;18 (10):1333-1342. doi: 10.1039/c6em00337k. PubMed PMID:27711787
  7. Theodorou, IG, Ruenraroengsak, P, Gow, A, Schwander, S, Zhang, JJ, Chung, KF, Tetley, TD, Ryan, MP, Porter, AE. Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells. Nanotoxicology. 2016;10 (9):1351-62. doi: 10.1080/17435390.2016.1214762. PubMed PMID:27441789 PubMed Central PMC5322737
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Categories: Faculty, Environmental Health Policy

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