EOHSI

Biographical Info

Research Areas

The Zhou laboratory is interested in the mechanisms mediating cell-cell communication and their roles in normal development, physiology, and diseases. Specifically the Zhou laboratory is investigating the functions of a large family of tyrosine kinase receptors, the Ephs, and their ligands, the ephrins, in neural circuit formation, eye development, and behavior regulations including motor activity, circadian rhythm, and aggression. The Zhou laboratory employs both in vitro and in vivo techniques, including neuron cultures, transgenic and knockout mice, as well as behavior assays.

Research Highlights

Demonstration of a repulsive function of ephrins in axon guidance

Discovering signal transduction pathways mediating ephrin-induced growth cone guidance

Establishing a novel cataract mouse model

Elucidating regulation of cell-cell adhesion by ephrins

Scholarly Activities

Member of editorial board: Neuroscience Bulletin; Cell & Bioscience

Membership in: AAAS, Society of Neuroscice, ARVO

Recent Publications

1. Gao, S, Lu, B, Zhou, R, Gao, W. Anatomical and Histological Study of the Upper Tarsus in Asian. J Craniofac Surg. 2023; :. doi: 10.1097/SCS.0000000000009397. PubMed PMID:37259202
2. Zilbauer, M, James, KR, Kaur, M, Pott, S, Li, Z, Burger, A, Thiagarajah, JR, Burclaff, J, Jahnsen, FL, Perrone, F et al.. A Roadmap for the Human Gut Cell Atlas. Nat Rev Gastroenterol Hepatol. 2023; :. doi: 10.1038/s41575-023-00784-1. PubMed PMID:37258747
3. Song, P, Chen, X, Zhang, P, Zhou, Y, Zhou, R. miR-200b/MYBL2/CDK1 suppresses proliferation and induces senescence through cell cycle arrest in ovine granulosa cells. Theriogenology. 2023;207 :19-30. doi: 10.1016/j.theriogenology.2023.05.022. PubMed PMID:37257219
4. Zhou, R, Xie, X, Wang, J, Ma, B, Hao, X. Why do children with autism spectrum disorder have abnormal visual perception?. Front Psychiatry. 2023;14 :1087122. doi: 10.3389/fpsyt.2023.1087122. PubMed PMID:37255685 PubMed Central PMC10225551
5. Zhou, R, Zhang, S, Nguyen, HT, Ding, H, Gaffney, A, Kappes, JC, Smith, AB 3rd, Sodroski, JG. Conformations of Human Immunodeficiency Virus Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles. J Virol. 2023; :e0032723. doi: 10.1128/jvi.00327-23. PubMed PMID:37255444
6. Lin, J, Tao, L, Deng, L, Zhou, R, Lou, S, Chen, S, Chen, X, Lu, C, Li, P, Hu, B et al.. Epigenome-wide DNA methylation analysis of myasthenia gravis. FEBS Open Bio. 2023; :. doi: 10.1002/2211-5463.13656. PubMed PMID:37254650
7. Liu, D, Cui, J, Zhou, R, He, C, Cao, J, Li, C. Comparison and enrichment of sn-2 palmitoyl triacylglycerols (OPO/OPL) in fish oil for its potential application as human milk fat substitutes. Food Res Int. 2023;169 :112836. doi: 10.1016/j.foodres.2023.112836. PubMed PMID:37254410