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Phoebe Stapleton, Ph.D., A.T.C.

Assistant Professor Rutgers University-Ernest Mario School of PharmacyEOHSI- Toxicology
Work EOHSI Rooms 428 (office) & 331 (Lab) 170 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-0142 -Office Work Phone: 848-445-0113 – Lab
Photo of Phoebe Stapleton Ph.D., A.T.C.

Biographical Info

Dr. Stapleton is an Assistant Professor in the Rutgers University, Ernest Mario School of Pharmacy, Department of Pharmacology and Toxicology, and the Joint Graduate Program in Toxicology. She received her B.S. in Biology and Athletic Training from State University of New York (SUNY) College at Cortland, a M.S.Ed. in Kinesiology from Southern Illinois University at Edwardsville, and a Ph.D. in Exercise Physiology from West Virginia University. She completed her postdoctoral training within the Department of Physiology and Pharmacology at West Virginia University.

Research Areas

The microcirculation branch of the cardiovascular system encompasses the arterioles, capillaries, and venules within an organ or tissue of interest. These highly active vessels serve to maintain homeostasis by regulating blood flow and tissue perfusion, thus providing nutrients and removing waste. Central to proper reactivity is the health and function of the endothelium, a single cell layer lining the vasculature. The Stapleton laboratory investigates the microvascular perturbations associated with normal physiological challenges (exercise or pregnancy), disease, and exposures to environmental and/or occupational xenobiotics.

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Using engineered nanomaterials, studies focus on the question: how can something we inhale affect the cardiovascular system? Recently, her research group has investigated non-traditional models of exposure by incorporating reproductive toxicology. These studies focus on exposures during pregnancy leading to the development of a hostile gestational environment identified through microvascular evaluations of the mother. These prenatal exposures impact fetal development and may predispose future generations to cardiovascular aberrations. The Stapleton laboratory is funded by NIH K99ES024783.

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Research Highlights

  • Identified and visualized nanoplastic particles are able to translocate from the maternal lungs to the fetal tissues after pulmonary exposure in late pregnancy.
  • Development of a novel placental perfusion technique to quantify material transfer from the maternal uterine circulation to the fetal umbilical circulation and measure biomarkers of uteroplacental function.
  • Identification of the development of a hostile gestational environment after engineered nanomaterial exposure during pregnancy.
  • Development of a novel intravital microscopy technique to visualize the vasculature of the pregnant uterus.
  • Investigations of mitochondrial function and bioenergetics in young exposed to xenobiotic matter during gestation.
  • Identification of microvascular dysfunction and behavioral alterations associated with engineered nanomaterial exposure in gestation.

Scholarly Activities

  • Dr. Stapleton received the Outstanding New Environmental Scientist (ONES) Award from NIEHS.
  • Mr. Andrés D. Rivera Ruiz was awarded the SOT Undergraduate Diversity Award in 2021 for his work as an 2020 Virtual SURF trainee.
  • Ms. Chelsea Cary won the 2021 Graduate Student Trainee Award from the Cardiovascular Toxicology Specialty Section of the Society of Toxicology (SOT).
  • Dr. Stapleton received the 2021 New Career Scientist Award from the Reproductive and Developmental Toxicology Specialty Section of the Society of Toxicology (SOT).
  • Dr. Stapleton received the 2020 Young Investigator Award from the Inhalation and Respiratory Toxicology Specialty Section of the Society of Toxicology (SOT).
  • Invited speaker to the NIEHS 50th Anniversary Celebration with SOT titled SOT and NIEHS Past, Present, and Future: 50 Years of Collaboration.
  • Past-President of the Allegheny-Erie Regional Chapter of the Society of Toxicology.
  • Dr. Stapleton recently published a symposia review of Gestational Nanomaterial Exposures in the Journal of Physiology (2016) 594(8):2161-73. (http://www.ncbi.nlm.nih.gov/pubmed/26332609)
  • Dr. Stapleton has been awarded the Impact Award by the Cardiovascular Toxicology Specialty Section of SOT (2016), the Best Publication Award by the Nanotoxicology Specialty Section of SOT (2016), and the Best Postdoctoral Publication Award by the Postdoctoral Assembly of SOT (2014).
  • Appointed as Review Editor for Frontiers in Vascular Physiology (2012).

In the News

Recent Publications

  1. Fournier, SB, Lam, V, Goedken, MJ, Fabris, L, Stapleton, PA. Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation. Sci Rep. 2021;11 (1):19374. doi: 10.1038/s41598-021-98818-8. PubMed PMID:34588535 PubMed Central PMC8481306
  2. Fournier, SB, D'Errico, JN, Stapleton, PA. Uterine Vascular Control Preconception and During Pregnancy. Compr Physiol. 2021;11 (3):1871-1893. doi: 10.1002/cphy.c190015. PubMed PMID:34061977 PubMed Central PMC8485361
  3. D'Errico, JN, Fournier, SB, Stapleton, PA. Considering intrauterine location in a model of fetal growth restriction after maternal titanium dioxide nanoparticle inhalation. Front Toxicol. 2021;3 :. doi: 10.3389/ftox.2021.643804. PubMed PMID:33997857 PubMed Central PMC8121264
  4. Fournier, SB, D'Errico, JN, Adler, DS, Kollontzi, S, Goedken, MJ, Fabris, L, Yurkow, EJ, Stapleton, PA. Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy. Part Fibre Toxicol. 2020;17 (1):55. doi: 10.1186/s12989-020-00385-9. PubMed PMID:33099312 PubMed Central PMC7585297
  5. Stapleton, PA. Toxicological considerations of nano-sized plastics. AIMS Environ Sci. 2019;6 (5):367-378. doi: 10.3934/environsci.2019.5.367. PubMed PMID:31745497 PubMed Central PMC6863350
  6. D'Errico, JN, Doherty, C, Fournier, SB, Renkel, N, Kallontzi, S, Goedken, M, Fabris, L, Buckley, B, Stapleton, PA. Identification and quantification of gold engineered nanomaterials and impaired fluid transfer across the rat placenta via ex vivo perfusion. Biomed Pharmacother. 2019;117 :109148. doi: 10.1016/j.biopha.2019.109148. PubMed PMID:31347503 PubMed Central PMC6682450
  7. D'Errico, JN, Fournier, SB, Stapleton, PA. Ex Vivo Perfusion of the Rodent Placenta. J Vis Exp. 2019; (147):. doi: 10.3791/59412. PubMed PMID:31205317 PubMed Central PMC6684279
  8. Butcher, JT, Murfee, WL, Stapleton, PA. Emerging topics in microvascular research: Advancing our understanding by interdisciplinary exploration. Microcirculation. 2019;26 (8):e12558. doi: 10.1111/micc.12558. PubMed PMID:31090984 PubMed Central PMC6916537
  9. Fournier, SB, Kallontzi, S, Fabris, L, Love, C, Stapleton, PA. Effect of Gestational Age on Maternofetal Vascular Function Following Single Maternal Engineered Nanoparticle Exposure. Cardiovasc Toxicol. 2019;19 (4):321-333. doi: 10.1007/s12012-019-09505-0. PubMed PMID:30734150 PubMed Central PMC6642065
  10. D'Errico, JN, Stapleton, PA. Developmental onset of cardiovascular disease-Could the proof be in the placenta?. Microcirculation. 2019;26 (8):e12526. doi: 10.1111/micc.12526. PubMed PMID:30597690 PubMed Central PMC6599488
Search PubMed
  1. Engler-Chiurazzi EB, Stapleton PA, Stalnaker JJ, Rambo-Hernandez KE, Sarkar SN, Jun S, Quintana DD, Ren X, Hu Heng, Nurkiewicz TR, McBride CR, Yi J, Simpkins JW. Adult Behavioral Consequences of Prenatal Engineered Nanomaterial Exposure in Rodents. Journal of Toxicology and Environmental Health Part A. 2016; 79(11): 447-52. doi: 10.1080/15287394.2016.1164101.
  2. Stapleton PA. Gestational xenobiotic exposures: microvascular implications for the past, present, and future. Journal of Physiology. Apr; 594(8): 2161-73, 2016. (invited symposium review) doi: 10.1113/JP270581.
  3. Stapleton PA, Nichols CE, Yi J, McBride CR, Minarchick VC, Shepherd DL, Hollander JM, Nurkiewicz TR. Microvascular and mitochondrial dysfunction in the female F1 generation after gestational TiO2 nanoparticle exposure. Nanotoxicology. 2015 Nov;9(8): 941-51. doi: 10.3109/17435390.2014.984251.
  4. Nichols CE, Shepherd DL, Knuckles TL, Thapa D, Stricker JC, Stapleton PA, Minarchick VC, Alway SE, Nurkiewicz TR, Hollander JM. Cardiac and Mitochondrial Dysfunction Following Acute Pulmonary Exposure to Mountaintop Removal Mining Particulate Matter. American Journal of Physiology – Heart and Circulatory Physiology. Dec; 309(12): H2017-30, 2015. doi: 10.1152/ajpheart.00353.2015.
  5. Stapleton PA, McBride CR, Yi J, Nurkiewicz TR. Uterine microvascular sensitivity to nanomaterial inhalation: an in vivo assessment. Toxicology and Applied Pharmacology. Nov; 288(3): 420-8, 2015. doi: 10.1016/j.taap.2015.08.013
  6. Stapleton PA, Minarchick VC, Yi J, Engels K, McBride CR, Nurkiewicz TR. Maternal engineered nanomaterial exposure and fetal microvascular function: does the Barker hypothesis apply? Am J Obstet Gynecol. Sep; 209(3): 227.e1-227.e11, 2013. doi: 10.1016/j.ajog.2013.04.036.
  7. Stapleton PA, Minarchick VC, Cumpston AM, McKinney W, Chen BT, Sager TM, Frazer DG, Mercer RR, Scabilloni J, Andrew M, Castranova V, Nurkiewicz TR. Impairment of coronary arteriolar endothelium-dependent dilation after multiwalled-carbon nanotube inhalation: a time course study. IJMS. Oct; 13: 13781-13803, 2012. doi: 10.3390/ijms131113781.
  8. Stapleton PA, Minarchick V, Knuckles TL, Nurkiewicz TR. Xenobiotic Particle Exposure and Microvascular Endpoints: A Call to Arms. Microcirculation. Feb; 19(2):126-42, 2012. doi: 10.1111/j.1549-8719.2011.00137.x.
Categories: Faculty, Toxicology, Member, Tox Member
Updated 6 months ago.