Mingzhu Fang MD, PhD, DABTAssistant Professor Rutgers -School of Public HealthEOHSI – Toxicology
Dr. Fang is an Assistant Professor at the Department of Environmental & Occupational Health in the School of Public Health at Rutgers University. She obtained her M.D. in Clinical Medicine in 1987 and a M.S. in Pathology in 1990 from Norman Bethune Medical School at Jilin University in China. She received her Ph.D. in Toxicology from Seoul National University of South Korea in 2000, as well as post-doctoral training in School of Pharmacy at Rutgers University in 2004. Recently (2014), she is recognized as a Diplomate of the American Board of Toxicology (D.A.B.T.).
Dr. Fang’s research focuses on genetic and epigenetic mechanisms in carcinogenesis and chemoprevention. She has been studying epigenetic chemopreventive activities of dietary compounds (e.g. tea polyphenols and methylselenocysteine). Recently, she is interested in epigenetic regulation of circadian rhythm in carcinogenesis and chemoprevention of breast cancer, biomarker discovery of circadian disruption, and intervention strategy development for shift workers
- 2013 International Collaboration Award from S. Korea
- 2012 SOT Colgate-Palmolive Grant for Alternative Research
- 2010 NIEHS CEED Career Development Award
- 2004 Annual Bibliography of Significant Advances in Dietary Supplements Research by ODS, NIH
- 2003 Honored on the Cover of Cancer Res
- 2003 Gallo Award in 2003 Annual Retreat on Cancer Research in New Jersey (ARCRNJ)
- 2002 The New Jersey Cancer Research Award for Scientific Excellence, 2002 ARCRNJ
- 2000 Yong Investigator Award, Asian Society of Toxicology, 2000 ASIATOX II
- Fang, M, Ohman Strickland, PA, Kang, HG, Zarbl, H. Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis. Oncotarget. 2017; :. doi: 10.18632/oncotarget.15678. PubMed PMID:28427145
- Sunil, VR, Vayas, KN, Fang, M, Zarbl, H, Massa, C, Gow, AJ, Cervelli, JA, Kipen, H, Laumbach, RJ, Lioy, PJ et al.. World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung. Exp. Mol. Pathol. 2017;102 (1):50-58. doi: 10.1016/j.yexmp.2016.12.005. PubMed PMID:27986442
- Fang, M, Guo, WR, Park, Y, Kang, HG, Zarbl, H. Enhancement of NAD⁺-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells. Oncotarget. 2015;6 (40):42879-91. doi: 10.18632/oncotarget.6002. PubMed PMID:26544624 PubMed Central PMC4767478
- Fang MZ, Ohman-Strickland P, Kelly-McNeil K, Kipen H, Crabtree BF, Lew JP, et al. Sleep interruption associated with house staff work schedules alters circadian gene expression. Sleep Med. 2015;16(11):1388-94. doi: 10.1016/j.sleep.2015.06.011. PubMed PMID: 26498241; PubMed Central PMCID: PMC4621493.
- Fang MZ, Zhang X, and Zarbl H. Methylselenocysteine resets the rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivo. Cancer prevention research. 2010;3(5):640-52. PMID: 20424134 PMCID: PMC2865563 DOI: 10.1158/1940-6207.CAPR-09-0170
- Fang MZ*, Wang Y*, Ai N, Hou Z, Sun Y, Lu H, Welsh W, Yang CS. Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer research. 2003;63(22):7563-70. PMID: 14633667. * Co-first author
- Wang Y*, Fang MZ*, Liao J, Yang GY, Nie Y, Song Y, So C, Xu X, Wang LD, Yang CS. Hypermethylation-associated inactivation of retinoic acid receptor beta in human esophageal squamous cell carcinoma. Clinical cancer research: an official journal of the American Association for Cancer Research. 2003;9(14):5257-63. PMID: 14614007.* Co-first author.
- Fang MZ, Chen D, Sun Y, Jin Z, Christman JK, Yang CS. Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. Clinical cancer research: an official journal of the American Association for Cancer Research. 2005;11(19 Pt 1):7033-41. doi: 10.1158/1078-0432.CCR-05-0406. PMID: 16203797.
Complete List of Her Published Work Can be found in My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47350630/?sort=date&direction=ascending