Kenneth Reuhl Ph.D., D.A.B.T. » EOHSI Directory

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Kenneth Reuhl Ph.D., D.A.B.T.

Professor and EOHSI Interim Director Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Address EOHSI Room 218 170 Frelinghuysen Road Piscataway NJ 08854 Phone: 848-445-0205 (EOHSI) Phone: 848-445-1430 (other) Fax: 732-445-0131 (EOHSI) Fax: 732-445-6905 (Gordon Rd)
Photo of Kenneth Reuhl Ph.D., D.A.B.T.

Biographical Info

Research Areas

My laboratory is interested in numerous facets of central nervous system pathology, particularly in developmental neurotoxicology, traumatic brain injury, and the differential responses of various CNS cell types to insult.  We are particularly interested in the recruitment of endogenous neural stem cells to sites of injury as a potential therapeutic approach to brain injury.

The laboratory also provides diagnostic histopathology support to investigators across the Rutgers community

Research Highlights

  • Established a lateral fluid percussion model for TBI and initiated studies of persistent blood-brain-barrier defects following closed-head injury
  • Investigated the comparative neurotoxicity of amphoterocin-type fungicides
  • Examining the developmental pathology of low-dose methylmercury exposure in vitro and in vivo
  • Documented recruitment of periventricular stem cells to the hippocampus following chemical injury

Scholarly Activities

  • Review Article Editor-NeuroToxicology
  • President-MidAtlantic Society of Toxicology
  • External Advisory Committee-University of Michigan Toxicology Program

Recent Publications

  1. Meng, Y, Wiseman, JA, Nemtsova, Y, Moore, DF, Guevarra, J, Reuhl, K, Banks, WA, Daneman, R, Sleat, DE, Lobel, P et al.. A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism. Mol. Ther. 2017;25 (7):1531-1543. doi: 10.1016/j.ymthe.2017.03.037. PubMed PMID:28456380 PubMed Central PMC5498811
  2. Garbuzenko, OB, Ivanova, V, Kholodovych, V, Reimer, DC, Reuhl, KR, Yurkow, E, Adler, D, Minko, T. Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s). Nanomedicine. 2017;13 (6):1983-1992. doi: 10.1016/j.nano.2017.04.005. PubMed PMID:28434932 PubMed Central PMC5546883
  3. Chen, JX, Wang, H, Liu, A, Zhang, L, Reuhl, K, Yang, CS. From the Cover: PhIP/DSS-Induced Colon Carcinogenesis in CYP1A-Humanized Mice and the Possible Role of Lgr5+ Stem Cells. Toxicol. Sci. 2017;155 (1):224-233. doi: 10.1093/toxsci/kfw190. PubMed PMID:27664423 PubMed Central PMC5216652
  4. Das, G, Yu, Q, Hui, R, Reuhl, K, Gale, NW, Zhou, R. EphA5 and EphA6: regulation of neuronal and spine morphology. Cell Biosci. 2016;6 :48. doi: 10.1186/s13578-016-0115-5. PubMed PMID:27489614 PubMed Central PMC4971699
  5. Lasfar, A, de laTorre, A, Abushahba, W, Cohen-Solal, KA, Castaneda, I, Yuan, Y, Reuhl, K, Zloza, A, Raveche, E, Laskin, DL et al.. Concerted action of IFN-α and IFN-λ induces local NK cell immunity and halts cancer growth. Oncotarget. 2016;7 (31):49259-49267. doi: 10.18632/oncotarget.10272. PubMed PMID:27363032 PubMed Central PMC5226505
  6. Chen, JX, Liu, A, Lee, MJ, Wang, H, Yu, S, Chi, E, Reuhl, K, Suh, N, Yang, CS. δ- and γ-tocopherols inhibit phIP/DSS-induced colon carcinogenesis by protection against early cellular and DNA damages. Mol. Carcinog. 2017;56 (1):172-183. doi: 10.1002/mc.22481. PubMed PMID:27175800
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Categories: Faculty, Toxicology, Central Administration

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