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Jeffrey D Laskin Ph.D.

Professor & Chief, Division of Toxicology Rutgers University – School of Public HealthEOHSI – Toxicology
Work EOHSI Room 441 170 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-0176 Work Fax: 732-445-0130
Photo of Jeffrey D Laskin Ph.D.

Biographical Info

Professor & Chief, Division of Toxicology
Environmental and Occupational Medicine
Robert Wood Johnson Medical School, Piscataway, NJ

Director of the Division of Toxicology
Environmental and Occupational Health Sciences Institute (EOHSI)
Robert Wood Johnson Medical School and Rutgers University, Piscataway, NJ

Rutgers University CounterACT Research Center of Excellence
Robert Wood Johnson Medical School and Rutgers University, Piscataway, NJ

Research Areas
Dr. Jeffrey D. Laskin is a Professor and Chief of the Division of Toxicology in the Department of Environmental and Occupational Medicine at Robert Wood Johnson Medical School (RWJMS). He is director of the Toxicology Division at the Environmental and Occupational Health Sciences Institute (EOHSI), a joint program of Rutgers University and RWJMS and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. He is Director of the UMDNJ/Rutgers University CounterACT Research Center of Excellence, a major White House initiated national security priority to expedite research on the most promising scientific discoveries that would lead to improved medical countermeasures to protect Americans against a chemical, biological, radiological, or nuclear (CBRN) attack. He is a member of the NJ Department of Homeland Security Preparedness College and is a founding member of the Executive Committee of the University Center for Disaster Preparedness and Emergency Response of RWJMS-UMDNJ, Rutgers University, and Robert Wood Johnson University Hospital.

Dr. Laskin received a B.A. in Chemistry and Biology from New York University, NY and a Ph.D. in Experimental Therapeutics from Roswell Park Cancer Institute, SUNY at Buffalo, NY. He was a post-doctoral fellow in the Institute for Cancer Research at the College of Physicians and Surgeons at Columbia University in NY before joining the faculty the Robert Wood Johnson Medical School. Dr. Laskin has served on numerous study sections for the National Institutes of Health and was an invited participant at the National Institutes of Arthritis and Musculoskeletal Disorders Roundtable on Wound Healing. He is a member of the Graduate School at Rutgers University, the Pharmacology graduate program at Robert Wood Johnson Medical School and the Cancer Institute of New Jersey. Dr. Laskin also serves as a member of the corporation of the Marine Biological Laboratory in Woods Hole, Massachusetts.

Dr. Laskin has served as an editor on over 20 journals that deal with pharmacology, toxicology and cancer research. With over 150 peer-reviewed publications, a book, numerous book chapters and editorials, he has been recognized as one of the most cited scientists in the field of chemical toxicology. His research focuses on mechanisms of chemical-induced skin, lung and liver toxicity. He is an expert in phototoxicology and redox chemistry. Dr. Laskin has been continuously funded by the NIH for the last 25 years and has served as PI on numerous RO1’s, as a Program Project PI and as a Center Director. Currently, he is completing research on exposure and health effects of chemical warfare agents and is working to identify countermeasures to sulfur mustard exposure.

Research Highlights

  • Demonstrated that sulfur mustard induces autophagy in the skin
  • Developed models for sulfur mustard-induced skin and lung toxicity
  • Synthesized >100 inhibitors of chemical-induced skin and lung injury
  • Demonstrated that UVB light is an inducer of prostaglandin and leukotriene biosynthetic enzymes

Scholarly Activities

  • Founder, New Jersey Basic and Applied Dermatology Forum
  • NASA, Issues in Advanced Environmental Health and Advanced Food Technology
  • NIH grant reviewer
  • Member, Cancer Institute of New Jersey
  • Member, NJ Department of Homeland Security Preparedness College
  • Executive Committee, NJ Universities Homeland Security Research Consortium
  • Executive Committee, University Center for Disaster Preparedness and Emergency Response
  • Director, Rutgers University CounterACT Research Center of Excellence

Recent Publications

  1. Son, Y, Mishin, V, Laskin, JD, Mainelis, G, Wackowski, OA, Delnevo, C, Schwander, S, Khlystov, A, Samburova, V, Meng, Q et al.. Hydroxyl Radicals in E-Cigarette Vapor and E-Vapor Oxidative Potentials under Different Vaping Patterns. Chem. Res. Toxicol. 2019; :. doi: 10.1021/acs.chemrestox.8b00400. PubMed PMID:30977360
  2. Jan, YH, Heck, DE, Laskin, DL, Laskin, JD. Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells. Chem. Res. Toxicol. 2019; :. doi: 10.1021/acs.chemrestox.8b00417. PubMed PMID:30964658
  3. Sunil, VR, Radbel, J, Hussain, S, Vayas, KN, Cervelli, J, Deen, M, Kipen, H, Udasin, I, Laumbach, R, Sunderram, J et al.. Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers. Int J Environ Res Public Health. 2019;16 (5):. doi: 10.3390/ijerph16050815. PubMed PMID:30845693 PubMed Central PMC6427752
  4. Guillon, CD, Jan, YH, Foster, N, Ressner, J, Heck, DE, Laskin, JD, Heindel, ND. Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions. Bioorg. Med. Chem. Lett. 2019;29 (4):619-622. doi: 10.1016/j.bmcl.2018.12.048. PubMed PMID:30638875 PubMed Central PMC6364570
  5. Szilagyi, JT, Composto-Wahler, GM, Joseph, LB, Wang, B, Rosen, T, Laskin, JD, Aleksunes, LM. Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis. Pharmacol. Res. 2019;141 :331-342. doi: 10.1016/j.phrs.2019.01.002. PubMed PMID:30610963 PubMed Central PMC6391190
  6. Laskin, DL, Malaviya, R, Laskin, JD. Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants. Toxicol. Sci. 2019;168 (2):287-301. doi: 10.1093/toxsci/kfy309. PubMed PMID:30590802 PubMed Central PMC6432864
  7. Szilagyi, JT, Gorczyca, L, Brinker, A, Buckley, B, Laskin, JD, Aleksunes, LM. Placental BCRP/ABCG2 Transporter Prevents Fetal Exposure to the Estrogenic Mycotoxin Zearalenone. Toxicol. Sci. 2019;168 (2):394-404. doi: 10.1093/toxsci/kfy303. PubMed PMID:30576553 PubMed Central PMC6432861
  8. Szilagyi, JT, Fussell, KC, Wang, Y, Jan, YH, Mishin, V, Richardson, JR, Heck, DE, Yang, S, Aleksunes, LM, Laskin, DL et al.. Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. Toxicol. Appl. Pharmacol. 2018;359 :102-107. doi: 10.1016/j.taap.2018.09.011. PubMed PMID:30222979
  9. Sunil, VR, Vayas, KN, Cervelli, JA, Ebramova, EV, Gow, AJ, Goedken, M, Malaviya, R, Laskin, JD, Laskin, DL. Protective Role of Surfactant Protein-D Against Lung Injury and Oxidative Stress Induced by Nitrogen Mustard. Toxicol. Sci. 2018;166 (1):108-122. doi: 10.1093/toxsci/kfy188. PubMed PMID:30060251 PubMed Central PMC6204765
  10. Chang, YC, Soriano, M, Hahn, RA, Casillas, RP, Gordon, MK, Laskin, JD, Gerecke, DR. Expression of cytokines and chemokines in mouse skin treated with sulfur mustard. Toxicol. Appl. Pharmacol. 2018;355 :52-59. doi: 10.1016/j.taap.2018.06.008. PubMed PMID:29935281 PubMed Central PMC6438172
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Categories: Faculty, Toxicology
Updated 5 months ago.
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