< Jeffrey D Laskin Ph.D. EOHSI Directory | EOHSI

Jeffrey D Laskin Ph.D. » EOHSI Directory

A B C D E F G H I J K L M N O P R S T U W Y Z

Jeffrey D Laskin Ph.D.

Distinguished Professor & Director, Division of Toxicology/Environmental and Occupational Health Sciences Institute Rutgers University – School of Public HealthEOHSI – Toxicology
Work EOHSI Room 441 170 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-0170
Photo of Jeffrey D Laskin Ph.D.

Biographical Info

Distinguished Professor
Department of Environmental & Occupational Health
Environmental and Occupational Health Sciences Institute
Rutgers University School of Public Health, Piscataway, NJ

Director of the Division of Toxicology
Environmental and Occupational Health Sciences Institute (EOHSI)
Rutgers University School of Public Health, Piscataway, NJ

Director
Rutgers University CounterACT Research Center of Excellence
Rutgers University School of Public Health, Piscataway, NJ

 

Research Areas

Dr. Jeffrey D. Laskin is a Distinguished Professor in the School of Public Health at Rutgers University.  He is Director of the Division of Toxicology at the Environmental and Occupational Health Sciences Institute (EOHSI) and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. He is Director of the Rutgers University CounterACT Research Center of Excellence, a major research effort to develop the most promising scientific discoveries that lead to improved medical countermeasures to protect Americans against a chemical attack.

Dr. Laskin received a B.A. in Chemistry and Biology from New York University, NY and a Ph.D. in Experimental Therapeutics from Roswell Park Cancer Institute, SUNY at Buffalo, NY. He was a post-doctoral fellow in the Institute for Cancer Research at the College of Physicians and Surgeons at Columbia University in NY before joining the faculty the Robert Wood Johnson Medical School and the School of Public Health at Rutgers University. Dr. Laskin has served on numerous study sections for the National Institutes of Health and was an invited participant at the National Institutes of Arthritis and Musculoskeletal Disorders Roundtable on Wound Healing. He is a member of the Cancer Institute of New Jersey, the Graduate School of Biomedical Sciences at Rutgers University and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. Dr. Laskin has also served as a member of the corporation of the Marine Biological Laboratory in Woods Hole, Massachusetts.

Dr. Laskin has served as a reviewer on over 30 journals that deal with pharmacology, toxicology and cancer research. With over 250 peer-reviewed publications, three books, and numerous book chapters and editorials, he has been recognized as one of the most cited scientists in the field of chemical toxicology. His research focuses on mechanisms of chemical-induced skin, lung and liver toxicity. He is an expert in mechanisms of chemical toxicity, phototoxicology and redox chemistry. Dr. Laskin has been continuously funded by the NIH for the last 35 years and has served as PI on numerous RO1’s, as a Program Project PI and as a Center Director. Currently, he is completing research on exposure and health effects of chemical warfare agents and is working to identify countermeasures to sulfur mustard exposure.

Research Highlights

  • Demonstrated that sulfur mustard induces autophagy in the skin
  • Developed models for sulfur mustard-induced skin and lung toxicity
  • Synthesized >100 inhibitors of chemical-induced skin and lung injury
  • Demonstrated that UVB light is an inducer of prostaglandin and leukotriene biosynthetic enzymes

Scholarly Activities

  • Founder, New Jersey Basic and Applied Dermatology Forum
  • NASA, Issues in Advanced Environmental Health and Advanced Food Technology
  • NIH grant reviewer
  • Member, Cancer Institute of New Jersey
  • Member, NJ Department of Homeland Security Preparedness College
  • Executive Committee, NJ Universities Homeland Security Research Consortium
  • Executive Committee, University Center for Disaster Preparedness and Emergency Response
  • Director, Rutgers University CounterACT Research Center of Excellence

Recent Publications

  1. Laskin, JD, Wahler, G, Croutch, CR, Sinko, PJ, Laskin, DL, Heck, DE, Joseph, LB. Skin remodeling and wound healing in the Gottingen minipig following exposure to sulfur mustard. Exp. Mol. Pathol. 2020; :104470. doi: 10.1016/j.yexmp.2020.104470. PubMed PMID:32445752
  2. Chang, YC, Wang, JD, Chang, HY, Zhou, P, Hahn, RA, Gordon, MK, Laskin, JD, Gerecke, DR. Expression of Laminin γ2 Proteolytic Fragments in Murine Skin Following Exposure to Sulfur Mustard. Anat Rec (Hoboken). 2020;303 (6):1642-1652. doi: 10.1002/ar.24405. PubMed PMID:32421930
  3. Jan, YH, Heck, DE, Laskin, DL, Laskin, JD. DNA damage signaling in the cellular responses to mustard vesicants. Toxicol. Lett. 2020;326 :78-82. doi: 10.1016/j.toxlet.2020.03.008. PubMed PMID:32173488 PubMed Central PMC7224631
  4. Wahler, G, Heck, DE, Heindel, ND, Laskin, DL, Laskin, JD, Joseph, LB. Antioxidant/stress response in mouse epidermis following exposure to nitrogen mustard. Exp. Mol. Pathol. 2020;114 :104410. doi: 10.1016/j.yexmp.2020.104410. PubMed PMID:32113906 PubMed Central PMC7237310
  5. Andres, J, Smith, LC, Murray, A, Jin, Y, Businaro, R, Laskin, JD, Laskin, DL. Role of extracellular vesicles in cell-cell communication and inflammation following exposure to pulmonary toxicants. Cytokine Growth Factor Rev. 2020;51 :12-18. doi: 10.1016/j.cytogfr.2019.12.001. PubMed PMID:31901309 PubMed Central PMC7052797
  6. Malaviya, R, Laskin, JD, Laskin, DL. Long-term Respiratory Effects of Mustard Vesicants. Toxicol. Lett. 2020;319 :168-174. doi: 10.1016/j.toxlet.2019.10.026. PubMed PMID:31698045
  7. Sunil, VR, Vayas, KN, Abramova, EV, Rancourt, R, Cervelli, JA, Malaviya, R, Goedken, M, Venosa, A, Gow, AJ, Laskin, JD et al.. Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard. Toxicol. Appl. Pharmacol. 2020;387 :114798. doi: 10.1016/j.taap.2019.114798. PubMed PMID:31678244 PubMed Central PMC7066865
  8. Venosa, A, Smith, LC, Murray, A, Banota, T, Gow, AJ, Laskin, JD, Laskin, DL. Regulation of Macrophage Foam Cell Formation During Nitrogen Mustard (NM)-Induced Pulmonary Fibrosis by Lung Lipids. Toxicol. Sci. 2019;172 (2):344-358. doi: 10.1093/toxsci/kfz187. PubMed PMID:31428777 PubMed Central PMC6876262
  9. Guillon, C, Jan, YH, Heck, DE, Mariano, TM, Rapp, RD, Jetter, M, Kardos, K, Whittemore, M, Akyea, E, Jabin, I et al.. Phototoxicity of 7-oxycoumarins with keratinocytes in culture. Bioorg. Chem. 2019;89 :103014. doi: 10.1016/j.bioorg.2019.103014. PubMed PMID:31170642 PubMed Central PMC6656587
  10. Son, Y, Mishin, V, Laskin, JD, Mainelis, G, Wackowski, OA, Delnevo, C, Schwander, S, Khlystov, A, Samburova, V, Meng, Q et al.. Hydroxyl Radicals in E-Cigarette Vapor and E-Vapor Oxidative Potentials under Different Vaping Patterns. Chem. Res. Toxicol. 2019;32 (6):1087-1095. doi: 10.1021/acs.chemrestox.8b00400. PubMed PMID:30977360 PubMed Central PMC6579624
Search PubMed
Categories: Faculty, Toxicology, Divisions
Updated 2 weeks ago.
Skip to toolbar