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Jeffrey D Laskin Ph.D.

Distinguished Professor & Director, Division of Toxicology/Environmental and Occupational Health Sciences Institute Rutgers University – School of Public HealthEOHSI – Toxicology
Work EOHSI Room 441 170 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-0170
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Biographical Info

Distinguished Professor
Department of Environmental & Occupational Health
Environmental and Occupational Health Sciences Institute
Rutgers University School of Public Health, Piscataway, NJ

Director of the Division of Toxicology
Environmental and Occupational Health Sciences Institute (EOHSI)
Rutgers University School of Public Health, Piscataway, NJ

Director
Rutgers University CounterACT Research Center of Excellence
Rutgers University School of Public Health, Piscataway, NJ

 

Research Areas

Dr. Jeffrey D. Laskin is a Distinguished Professor in the School of Public Health at Rutgers University.  He is Director of the Division of Toxicology at the Environmental and Occupational Health Sciences Institute (EOHSI) and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. He is Director of the Rutgers University CounterACT Research Center of Excellence, a major research effort to develop the most promising scientific discoveries that lead to improved medical countermeasures to protect Americans against a chemical attack.

Dr. Laskin received a B.A. in Chemistry and Biology from New York University, NY and a Ph.D. in Experimental Therapeutics from Roswell Park Cancer Institute, SUNY at Buffalo, NY. He was a post-doctoral fellow in the Institute for Cancer Research at the College of Physicians and Surgeons at Columbia University in NY before joining the faculty the Robert Wood Johnson Medical School and the School of Public Health at Rutgers University. Dr. Laskin has served on numerous study sections for the National Institutes of Health and was an invited participant at the National Institutes of Arthritis and Musculoskeletal Disorders Roundtable on Wound Healing. He is a member of the Cancer Institute of New Jersey, the Graduate School of Biomedical Sciences at Rutgers University and is Deputy Director of the Joint Graduate Program in Toxicology at Rutgers University. Dr. Laskin has also served as a member of the corporation of the Marine Biological Laboratory in Woods Hole, Massachusetts.

Dr. Laskin has served as a reviewer on over 30 journals that deal with pharmacology, toxicology and cancer research. With over 250 peer-reviewed publications, three books, and numerous book chapters and editorials, he has been recognized as one of the most cited scientists in the field of chemical toxicology. His research focuses on mechanisms of chemical-induced skin, lung and liver toxicity. He is an expert in mechanisms of chemical toxicity, phototoxicology and redox chemistry. Dr. Laskin has been continuously funded by the NIH for the last 35 years and has served as PI on numerous RO1’s, as a Program Project PI and as a Center Director. Currently, he is completing research on exposure and health effects of chemical warfare agents and is working to identify countermeasures to sulfur mustard exposure.

Research Highlights

  • Demonstrated that sulfur mustard induces autophagy in the skin
  • Developed models for sulfur mustard-induced skin and lung toxicity
  • Synthesized >100 inhibitors of chemical-induced skin and lung injury
  • Demonstrated that UVB light is an inducer of prostaglandin and leukotriene biosynthetic enzymes

Scholarly Activities

  • Founder, New Jersey Basic and Applied Dermatology Forum
  • NASA, Issues in Advanced Environmental Health and Advanced Food Technology
  • NIH grant reviewer
  • Member, Cancer Institute of New Jersey
  • Member, NJ Department of Homeland Security Preparedness College
  • Executive Committee, NJ Universities Homeland Security Research Consortium
  • Executive Committee, University Center for Disaster Preparedness and Emergency Response
  • Director, Rutgers University CounterACT Research Center of Excellence

Recent Publications

  1. Malaviya, R, Laskin, JD, Laskin, DL. Long-term Respiratory Effects of Mustard Vesicants. Toxicol. Lett. 2019; :. doi: 10.1016/j.toxlet.2019.10.026. PubMed PMID:31698045
  2. Sunil, VR, Vayas, KN, Abramova, EV, Rancourt, R, Cervelli, JA, Malaviya, R, Goedken, M, Venosa, A, Gow, AJ, Laskin, JD et al.. Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard. Toxicol. Appl. Pharmacol. 2019; :114798. doi: 10.1016/j.taap.2019.114798. PubMed PMID:31678244
  3. Venosa, A, Smith, LC, Murray, A, Banota, T, Gow, AJ, Laskin, JD, Laskin, DL. Regulation of Macrophage Foam Cell Formation during Nitrogen Mustard (NM)-Induced Pulmonary Fibrosis by Lung Lipids. Toxicol. Sci. 2019; :. doi: 10.1093/toxsci/kfz187. PubMed PMID:31428777
  4. Guillon, C, Jan, YH, Heck, DE, Mariano, TM, Rapp, RD, Jetter, M, Kardos, K, Whittemore, M, Akyea, E, Jabin, I et al.. Phototoxicity of 7-oxycoumarins with keratinocytes in culture. Bioorg. Chem. 2019;89 :103014. doi: 10.1016/j.bioorg.2019.103014. PubMed PMID:31170642 PubMed Central PMC6656587
  5. Son, Y, Mishin, V, Laskin, JD, Mainelis, G, Wackowski, OA, Delnevo, C, Schwander, S, Khlystov, A, Samburova, V, Meng, Q et al.. Hydroxyl Radicals in E-Cigarette Vapor and E-Vapor Oxidative Potentials under Different Vaping Patterns. Chem. Res. Toxicol. 2019;32 (6):1087-1095. doi: 10.1021/acs.chemrestox.8b00400. PubMed PMID:30977360 PubMed Central PMC6579624
  6. Jan, YH, Heck, DE, Laskin, DL, Laskin, JD. Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells. Chem. Res. Toxicol. 2019;32 (6):1123-1133. doi: 10.1021/acs.chemrestox.8b00417. PubMed PMID:30964658 PubMed Central PMC6626495
  7. Sunil, VR, Radbel, J, Hussain, S, Vayas, KN, Cervelli, J, Deen, M, Kipen, H, Udasin, I, Laumbach, R, Sunderram, J et al.. Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers. Int J Environ Res Public Health. 2019;16 (5):. doi: 10.3390/ijerph16050815. PubMed PMID:30845693 PubMed Central PMC6427752
  8. Guillon, CD, Jan, YH, Foster, N, Ressner, J, Heck, DE, Laskin, JD, Heindel, ND. Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions. Bioorg. Med. Chem. Lett. 2019;29 (4):619-622. doi: 10.1016/j.bmcl.2018.12.048. PubMed PMID:30638875 PubMed Central PMC6364570
  9. Szilagyi, JT, Composto-Wahler, GM, Joseph, LB, Wang, B, Rosen, T, Laskin, JD, Aleksunes, LM. Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis. Pharmacol. Res. 2019;141 :331-342. doi: 10.1016/j.phrs.2019.01.002. PubMed PMID:30610963 PubMed Central PMC6391190
  10. Laskin, DL, Malaviya, R, Laskin, JD. Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants. Toxicol. Sci. 2019;168 (2):287-301. doi: 10.1093/toxsci/kfy309. PubMed PMID:30590802 PubMed Central PMC6432864
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Categories: Faculty, Toxicology
Updated 4 months ago.
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