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Jason R Richardson M.S., Ph.D., DABT

Adjunct Faculty Rutgers UniversityEOHSI – Toxicology
Work EOHSI Room 340 170 Frelinghuysen Road Piscataway NJ 08840 Work Phone: 330-325-6657
Photo of Jason R Richardson M.S., Ph.D., DABT

Biographical Info

Education

  • MS Mississippi State University
  • PhD Mississippi State University
  • Postdoctoral Fellow Emory University

Jason Richardson, M.S., Ph.D. DABT is a tenured Associate Professor and Board Certified Toxicologist in the Department of Environmental and Occupational Medicine at Rutgers Robert Wood Johnson Medical School and Resident Member of the Environmental and Occupational Health Sciences Institute. He received his M.S. (1999) and Ph.D. (2002) degrees from Mississippi State University where he conducted research on mixtures of organophosphate pesticides and the developmental neurotoxicity of organophosphates. He then completed postdoctoral training in Molecular Neuroscience at Emory University (2002-2005) where he focused on the role of pesticide exposure in Parkinson’s disease. His research at EOHSI focuses on the role of environmental exposures and their interactions with genetic susceptibility as contributors to neurological disease using translational approaches. Dr. Richardson has authored or co-authored over 60 publications that have been cited over 2,000 times in the areas of developmental neurotoxicology, neurodegenerative disease, and pesticides. He has received the Outstanding New Environmental Scientist Award from the National Institute of Environmental Health Sciences and a Young Scientist Award from the American Society for Pharmacology and Experimental Therapeutics. Dr. Richardson is currently a member of the Editorial boards of Toxicological Sciences and Neurotoxicology, Neurotoxicology and Teratology, and was an Associate Editor for BMC Neurology. He has served as a grant reviewer for several NIH panels, the Michael J. Fox Foundation for Parkinson’s Disease Research, Health Canada, and the United Kingdom Parkinson’s Disease Society. He also served the Society of Toxicology as Secretary/Treasurer of the Neurotoxicology Specialty Section for two years.

Research Areas

In general, the goals of our research are three-fold:

  • Determine the role of environmental exposure and interactions of environmental exposures and genetic
    susceptibility in the etiology of neurological disease.
  • Develop animal models of neurological disease and dysfunction based on environmental exposures and test
    therapeutic agents in these models
  • Identify novel and specific biomarkers of exposure and disease for early detection of disease or dysfunction
    of the nervous system.

More specifically, our research is currently focused on the role of pesticide exposures in the etiology and pathogenesis of Attention-deficit hyperactivity disorder (ADHD), Parkinson’s disease (PD), and Alzheimer’s Disease (AD). To accomplish our research goals, we make use of a variety of research techniques spanning from in vitro cell culture models to in vivo animal models and human populations and from molecular techniques to whole animal behavioral techniques.

In the News (follow the links)

Scholarly Activities

  • 2014-present: Member National Institute of Environmental Health Sciences Review Committee
  • 2014-present: Member National Academy of Science Comittee on Emerging Science for Environmental Health Decisions
  • 2009-present: Editorial Board Member Neurotoxicology
  • 2009-2013: Associate Editor BMC Neurology
  • 2010-present: Editorial Board Member Toxicological Sciences
  • 2010-present: Editorial Board Member Current Molecular Pharmacology
  • 2009: NIH Expert Panel Workshop on Toxic Industrial Chemicals (July 22-23, 2009), Bethesda, MD.
  • 2010: NIH/NIEHS Brainstorming Panel on Autism and the Environment (September 8, 2010), Research Triangle Park, NC
  • 2010: Co-Chair, 2010; 26th International Neurotoxicology Conference
  • 2011-present: Editorial Board Member Neurotoxicology and Teratology
  • 2011: Editor, Special Issue Neurotoxicology
  • 2013-present: Editorial Board Member Toxics

Recent Publications

  1. You, D, Wen, X, Gorczyca, L, Morris, A, Richardson, JR, Aleksunes, LM. Increased MDR1 Transporter Expression in Human Brain Endothelial Cells Through Enhanced Histone Acetylation and Activation of Aryl Hydrocarbon Receptor Signaling. Mol. Neurobiol. 2019; :. doi: 10.1007/s12035-019-1565-7. PubMed PMID:30963442
  2. You, D, Shin, HM, Mosaad, F, Richardson, JR, Aleksunes, LM. Brain region-specific regulation of histone acetylation and efflux transporters in mice. J. Biochem. Mol. Toxicol. 2019; :e22318. doi: 10.1002/jbt.22318. PubMed PMID:30897286
  3. Wen, X, Baker, AA, Klaassen, CD, Corton, JC, Richardson, JR, Aleksunes, LM. Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid. Toxicology. 2019;416 :15-22. doi: 10.1016/j.tox.2019.01.014. PubMed PMID:30685356 PubMed Central PMC6397673
  4. Szilagyi, JT, Fussell, KC, Wang, Y, Jan, YH, Mishin, V, Richardson, JR, Heck, DE, Yang, S, Aleksunes, LM, Laskin, DL et al.. Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. Toxicol. Appl. Pharmacol. 2018;359 :102-107. doi: 10.1016/j.taap.2018.09.011. PubMed PMID:30222979
  5. Tiethof, AK, Richardson, JR, Hart, RP. Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells. Toxics. 2018;6 (3):. doi: 10.3390/toxics6030052. PubMed PMID:30200437 PubMed Central PMC6160911
  6. Hossain, MM, Weig, B, Reuhl, K, Gearing, M, Wu, LJ, Richardson, JR. The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6. Exp. Neurol. 2018;308 :111-119. doi: 10.1016/j.expneurol.2018.07.005. PubMed PMID:30017881
  7. Bosco, DB, Zheng, J, Xu, Z, Peng, J, Eyo, UB, Tang, K, Yan, C, Huang, J, Feng, L, Wu, G et al.. RNAseq analysis of hippocampal microglia after kainic acid-induced seizures. Mol Brain. 2018;11 (1):34. doi: 10.1186/s13041-018-0376-5. PubMed PMID:29925434 PubMed Central PMC6011524
  8. Sheleg, M, Yochum, CL, Richardson, JR, Wagner, GC, Zhou, R. Corrigendum to "Ephrin-A5 regulates inter-male aggression in mice" [Behav. Brain Res. 286 (June) (2015) 300-307]. Behav. Brain Res. 2017;335 :223. doi: 10.1016/j.bbr.2017.08.019. PubMed PMID:28827072
  9. Beier, EE, Neal, M, Alam, G, Edler, M, Wu, LJ, Richardson, JR. Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide. Neurobiol. Dis. 2017;108 :115-127. doi: 10.1016/j.nbd.2017.08.009. PubMed PMID:28823928 PubMed Central PMC5734673
  10. Green, AL, Zhan, L, Eid, A, Zarbl, H, Guo, GL, Richardson, JR. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology. 2017;125 :189-196. doi: 10.1016/j.neuropharm.2017.07.020. PubMed PMID:28743636 PubMed Central PMC5585058
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Categories: Faculty, Toxicology
Updated 4 months ago.
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