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Howard Kipen MD, MPH

Professor, Department of Occupational and Environmental Health Rutgers University – School of Public HealthEOHSI – Director, Clinical Research and Occupational Medicine
Work EOHSI 208 170 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-6091 Work Phone: 848-445-0123 (for Clinic Appointments)
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Biographical Info

Research Areas

Dr. Kipen’s research focuses on clinical and epidemiological studies of the health effects of ambient and indoor air pollution. He works closely with Rob Laumbach of the CROM division as well as Debra Laskin and Andrew Gow of Toxicology. They use both controlled exposure models with ozone, fresh aerosols, and diesel-enriched on-road exposures, primarily with exposure-enhancing-drives on the New Jersey Turnpike. A current  EPA study examines health benefits of portable air cleaners used to reduce indoor air pollution levels in homes.  Biomarker outcomes presently emphasized are exhaled breath oxidative stress and invasive and noninvasive measures of vascular function.  Dr. Kipen is also a Co-I on an NIEHS-funded human exposure trial that explores macrophage activation and phenotype following ozone exposure.

Research Highlights

With former EOHSI members Jim Zhang and David Rich, we conducted a panel study of 130 Beijing medical students built around the Chinese Government’s drastic reductions in air pollution during the 2008 Olympics. We observed broad declines in multiple oxidative stress, inflammatory, and platelet activation biomarkers. Major results have been published in JAMA and the American Journal of Respiratory and Critical Care Medicine with multiple subsidiary papers and a complete report published by the Health Effects Institute.  Related effects have been shown with New Jersey air pollution on the Turnpike and are being evaluated with air cleaners in individual homes.

Significant declines in proteasome (UPP) activity after exposure to secondary organic aerosol and diesel exhaust were observed immediately following exposure in healthy subjects, although our prior work did reveal apparent health effects from acute exposures to secondary organic aerosol.

The above declines in proteasome activity showed a significant interaction (3-fold increase) in subjects with the ILE/ILE polymorphism of GSTP1.

Scholarly Activities

  • Chair, NASA Human Research Program’s Advanced Environmental Health / Advanced Food Technology Standing Review Panel (2015-2018)
  • Chair, Scientific Assembly on Environmental, Occupational, and Population Health, American Thoracic Society (2017-2019)
  • Member, National Academies Standing Committee on Medical and Epidemiological Aspects of Air Pollution on U.S. Government Employees and their Families, 2016-
  • Director, Integrated Health Sciences Facility Core, Rutgers Center for Environmental Exposures and Disease (CEED), NIEHS
  • Chair / Member Multiple Ad Hoc Grant Review Panels (e.g., NIEHS, Department of Defense)
  • Governor’s Appointee, Public Employee’s Occupational Safety and Health Review Commission, New Jersey Department of Labor
  • Member, Public Health Scientific Advisory Board, New Jersey Department of Environmental Protection

Howard Kipen’s Publications

Recent Publications

  1. Sunil, VR, Radbel, J, Hussain, S, Vayas, KN, Cervelli, J, Deen, M, Kipen, H, Udasin, I, Laumbach, R, Sunderram, J et al.. Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers. Int J Environ Res Public Health. 2019;16 (5):. doi: 10.3390/ijerph16050815. PubMed PMID:30845693 PubMed Central PMC6427752
  2. Chiao, S, Kipen, H, Hallman, WK, Pollio, DE, North, CS. Anthrax Exposure, Belief in Exposure, and Postanthrax Symptoms Among Survivors of a Bioterrorist Attack on Capitol Hill. Disaster Med Public Health Prep. 2018; :1-6. doi: 10.1017/dmp.2018.115. PubMed PMID:30417804
  3. Fiedler, N, Weisel, C, Nwankwo, C, Kipen, H, Lange, G, Ohman-Strickland, P, Laumbach, R. Chronic Exposure to Solvents Among Construction Painters: Reductions in Exposure and Neurobehavioral Health Effects. J. Occup. Environ. Med. 2018;60 (12):e663-e670. doi: 10.1097/JOM.0000000000001470. PubMed PMID:30308619 PubMed Central PMC6289817
  4. Gholizadeh, A, Voiry, D, Weisel, C, Gow, A, Laumbach, R, Kipen, H, Chhowalla, M, Javanmard, M. Toward point-of-care management of chronic respiratory conditions: Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide. Microsyst Nanoeng. 2017;3 :17022. doi: 10.1038/micronano.2017.22. PubMed PMID:31057865 PubMed Central PMC6444995
  5. Thurston, GD, Kipen, H, Annesi-Maesano, I, Balmes, J, Brook, RD, Cromar, K, De Matteis, S, Forastiere, F, Forsberg, B, Frampton, MW et al.. A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework. Eur. Respir. J. 2017;49 (1):. doi: 10.1183/13993003.00419-2016. PubMed PMID:28077473 PubMed Central PMC5751718
  6. Sunil, VR, Vayas, KN, Fang, M, Zarbl, H, Massa, C, Gow, AJ, Cervelli, JA, Kipen, H, Laumbach, RJ, Lioy, PJ et al.. World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung. Exp. Mol. Pathol. 2017;102 (1):50-58. doi: 10.1016/j.yexmp.2016.12.005. PubMed PMID:27986442 PubMed Central PMC5472054
  7. Patton, AP, Laumbach, R, Ohman-Strickland, P, Black, K, Alimokhtari, S, Lioy, P, Kipen, HM. Scripted drives: A robust protocol for generating exposures to traffic-related air pollution. Atmos Environ (1994). 2016;143 :290-299. doi: 10.1016/j.atmosenv.2016.08.038. PubMed PMID:27642251 PubMed Central PMC5019181
  8. Altemose, B, Robson, MG, Kipen, HM, Ohman Strickland, P, Meng, Q, Gong, J, Huang, W, Wang, G, Rich, DQ, Zhu, T et al.. Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress. J Expo Sci Environ Epidemiol. 2017;27 (3):244-250. doi: 10.1038/jes.2016.38. PubMed PMID:27436693
  9. Pettit, AP, Kipen, H, Laumbach, R, Ohman-Strickland, P, Kelly-McNeill, K, Cepeda, C, Fan, ZH, Amorosa, L, Lubitz, S, Schneider, S et al.. Disrupted Nitric Oxide Metabolism from Type II Diabetes and Acute Exposure to Particulate Air Pollution. PLoS ONE. 2015;10 (12):e0144250. doi: 10.1371/journal.pone.0144250. PubMed PMID:26656561 PubMed Central PMC4682772
  10. Son, Y, Mishin, V, Welsh, W, Lu, SE, Laskin, JD, Kipen, H, Meng, Q. A Novel High-Throughput Approach to Measure Hydroxyl Radicals Induced by Airborne Particulate Matter. Int J Environ Res Public Health. 2015;12 (11):13678-95. doi: 10.3390/ijerph121113678. PubMed PMID:26516887 PubMed Central PMC4661607
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Categories: Faculty, Clinical Research and Occupational Medicine
Updated 5 months ago.
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