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Grace L. Guo MBBS, Ph.D.

Associate Professor Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology
Work EOHSI Room 322 170 Frelinghuysen Rd Piscataway NJ 08854 Work Phone: 848-445-8186 (office) Work Phone: 848-445-6102 (Lab) Work Fax: 732-445-4161
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Biographical Info

Dr. Guo is an Associate Professor at the Department Pharmacology and Toxicology in the Ernest Mario School of Pharmacy of Rutgers University. She is an adjunct faculty of the Department of Pharmacology, Toxicology and Therapeutics in School of Medicine at the University of Kanas Medical Center.  Dr. Guo obtained her MBBS degree from the West China University of Medical Sciences in 1993 and a PhD degree from the University of Kansas Medical Center in 2001, as well as post-doctoral training at the NCI, NIH in 2004. From 2004-2012, Dr. Guo has served as a faculty at the University of Kansas Medical Center.

Research Areas

Liver is essential for life and liver functions are tightly regulated. Particularly, the impact of intestine on liver homeostasis, function and diseases is significant, but this impact has been less studied. Our group has been focusing on determining the effects of intestine-liver crosstalks on liver metabolism and pathogenesis and the underlying molecular mechanisms, especially following disruption of endogenous homeostasis and exposure to xenobiotic chemicals.

Scholarly Activities

  • 2012: Presidential Poster Award, AASLD meeting (2)
  • 2011: Presidential Poster Award, AASLD meeting
  • 2010: Presidential Poster Award, AASLD meeting
  • 2009: Presidential Poster Award, AASLD meeting
  • 2009: Post award winner for Annual Liver Center Symposium, University of Kansas Medical Center
  • 2007: First place in oral presentation in Annual Cancer Center Symposium, University of Kansas Medical Center
  • 2005: BIRCWH/NIH scholar

Recent Publications

  1. Nikonorova, IA, Zhu, Q, Signore, CC, Mirek, ET, Jonsson, WO, Kong, B, Guo, GL, Belden, WJ, Anthony, TG. Age modulates liver responses to asparaginase-induced amino acid stress in mice. J. Biol. Chem. 2019;294 (38):13864-13875. doi: 10.1074/jbc.RA119.009864. PubMed PMID:31413113 PubMed Central PMC6755797
  2. Schumacher, JD, Kong, B, Wu, J, Rizzolo, D, Armstrong, LE, Chow, MD, Goedken, M, Lee, YH, Guo, GL. Direct and Indirect Effects of Fibroblast Growth Factor (FGF) 15 and FGF19 on Liver Fibrosis Development. Hepatology. 2019; :. doi: 10.1002/hep.30810. PubMed PMID:31206730
  3. Schumacher, JD, Guo, GL. Pharmacologic Modulation of Bile Acid-FXR-FGF15/FGF19 Pathway for the Treatment of Nonalcoholic Steatohepatitis. Handb Exp Pharmacol. 2019;256 :325-357. doi: 10.1007/164_2019_228. PubMed PMID:31201553
  4. Armstrong, LE, Guo, GL. Understanding Environmental Contaminants' Direct Effects on Non-alcoholic Fatty Liver Disease Progression. Curr Environ Health Rep. 2019;6 (3):95-104. doi: 10.1007/s40572-019-00231-x. PubMed PMID:31090041 PubMed Central PMC6698395
  5. Byun, S, Jung, H, Chen, J, Kim, YC, Kim, DH, Kong, B, Guo, G, Kemper, B, Kemper, JK. Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis. J. Biol. Chem. 2019;294 (22):8732-8744. doi: 10.1074/jbc.RA119.008360. PubMed PMID:30996006 PubMed Central PMC6552419
  6. Dong, B, Singh, AB, Guo, GL, Young, M, Liu, J. Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR. Int. J. Mol. Med. 2019;43 (5):1927-1938. doi: 10.3892/ijmm.2019.4136. PubMed PMID:30896855 PubMed Central PMC6443341
  7. Rizzolo, D, Buckley, K, Kong, B, Zhan, L, Shen, J, Stofan, M, Brinker, A, Goedken, M, Buckley, B, Guo, GL et al.. Bile Acid Homeostasis in a Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mouse Model. Hepatology. 2019;70 (1):389-402. doi: 10.1002/hep.30612. PubMed PMID:30864232
  8. Kong, B, Zhang, M, Huang, M, Rizzolo, D, Armstrong, LE, Schumacher, JD, Chow, MD, Lee, YH, Guo, GL. FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury. Dig Liver Dis. 2019;51 (4):570-576. doi: 10.1016/j.dld.2018.12.026. PubMed PMID:30803859 PubMed Central PMC6451669
  9. Guo, GL, Xie, W. Metformin action through the microbiome and bile acids. Nat. Med. 2018;24 (12):1789-1790. doi: 10.1038/s41591-018-0273-6. PubMed PMID:30523325
  10. Kim, YC, Byun, S, Seok, S, Guo, G, Xu, HE, Kemper, B, Kemper, JK. Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption. Gastroenterology. 2019;156 (4):1052-1065. doi: 10.1053/j.gastro.2018.11.061. PubMed PMID:30521806 PubMed Central PMC6409196
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Categories: Faculty, Toxicology
Updated 10 months ago.
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