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Grace L. Guo MBBS, Ph.D.

Associate Professor Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology
Address EOHSI Room 322 170 Frelinghuysen Rd Piscataway NJ 08854 Phone: 848-445-8186 (office) Phone: 848-445-6102 (Lab) Fax: 732-445-4161
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Biographical Info

Dr. Guo is an Associate Professor at the Department Pharmacology and Toxicology in the Ernest Mario School of Pharmacy of Rutgers University. She is an adjunct faculty of the Department of Pharmacology, Toxicology and Therapeutics in School of Medicine at the University of Kanas Medical Center.  Dr. Guo obtained her MBBS degree from the West China University of Medical Sciences in 1993 and a PhD degree from the University of Kansas Medical Center in 2001, as well as post-doctoral training at the NCI, NIH in 2004. From 2004-2012, Dr. Guo has served as a faculty at the University of Kansas Medical Center.

Research Areas

Liver is essential for life and liver functions are tightly regulated. Particularly, the impact of intestine on liver homeostasis, function and diseases is significant, but this impact has been less studied. Our group has been focusing on determining the effects of intestine-liver crosstalks on liver metabolism and pathogenesis and the underlying molecular mechanisms, especially following disruption of endogenous homeostasis and exposure to xenobiotic chemicals.

Scholarly Activities

  • 2012: Presidential Poster Award, AASLD meeting (2)
  • 2011: Presidential Poster Award, AASLD meeting
  • 2010: Presidential Poster Award, AASLD meeting
  • 2009: Presidential Poster Award, AASLD meeting
  • 2009: Post award winner for Annual Liver Center Symposium, University of Kansas Medical Center
  • 2007: First place in oral presentation in Annual Cancer Center Symposium, University of Kansas Medical Center
  • 2005: BIRCWH/NIH scholar

Recent Publications

  1. Armstrong, LE, Guo, GL. Role of FXR in Liver Inflammation during Nonalcoholic Steatohepatitis. Curr Pharmacol Rep. 2017;3 (2):92-100. doi: 10.1007/s40495-017-0085-2. PubMed PMID:28983452 PubMed Central PMC5624538
  2. Huang, M, Williams, J, Kong, B, Zhu, Y, Li, G, Zhu, Z, Guo, GL. Fibroblast growth factor 15 deficiency increases susceptibility but does not improve repair to acetaminophen-induced liver injury in mice. Dig Liver Dis. 2017; :. doi: 10.1016/j.dld.2017.08.023. PubMed PMID:28867475
  3. Green, AL, Zhan, L, Eid, A, Zarbl, H, Guo, GL, Richardson, JR. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology. 2017;125 :189-196. doi: 10.1016/j.neuropharm.2017.07.020. PubMed PMID:28743636 PubMed Central PMC5585058
  4. Zheng, Z, Zhao, Z, Li, S, Lu, X, Jiang, M, Lin, J, An, Y, Xie, Y, Xu, M, Shen, W et al.. Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates Nonalcoholic Fatty Liver Disease by Activating the Farnesoid X Receptor. Mol. Pharmacol. 2017;92 (4):425-436. doi: 10.1124/mol.117.108829. PubMed PMID:28739572 PubMed Central PMC5588546
  5. Guo, GL. Why is the female population more susceptible to cholestasis-induced liver injury-Could it be long noncoding RNA H19?. Hepatology. 2017;66 (3):694-696. doi: 10.1002/hep.29255. PubMed PMID:28508397
  6. Byun, S, Kim, YC, Zhang, Y, Kong, B, Guo, G, Sadoshima, J, Ma, J, Kemper, B, Kemper, JK. A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy. EMBO J. 2017;36 (12):1755-1769. doi: 10.15252/embj.201695500. PubMed PMID:28446510 PubMed Central PMC5470039
  7. Chow, MD, Lee, YH, Guo, GL. The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Mol. Aspects Med. 2017;56 :34-44. doi: 10.1016/j.mam.2017.04.004. PubMed PMID:28442273
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Categories: Faculty, Toxicology
Updated 5 months ago.

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