My primary research area in my lab involves research involving the vesicating agent, sulfur mustard (SM). There are two basic sides to the research. The first is a basic research aspect that involves elucidating the mechanism of action of the SM. In this capacity, we are looking at the direct effect of SM on protein-protein interactions of molecules known to stabilize the skin structural integrity (eg various laminins, collagens, and their integrin receptors). We are also looking at the effects of SM on keratinocyte adhesion and migration with in vitro assays. We also have an applied research program that involves an in vivo mouse ear vesicant model. We use this model to test potential therapeutic countermeasure agents against SM-induced skin injury. We use various histological, wound repair, and gene profile analysis assays to evaluate these compounds.
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