Research Areas

Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.

Research Highlights

• Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
• Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
• Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
• Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
• Conducting translational research on tocopherols in prostate cancer patients.

Scholarly Activities

• Conduct research as described above.
• Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
• Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
• Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.

Recent Publications

1. Mun, SJ, Cho, E, Gil, WJ, Kim, SJ, Kim, HK, Ham, YS, Yang, CS. Dual alarmin-receptor-specific targeting peptide systems for treatment of sepsis. Acta Pharm Sin B. 2024;14 (12):5451-5463. doi: 10.1016/j.apsb.2024.08.015. PubMed PMID:39807314 PubMed Central PMC11725134
2. Yang, CS, Shie, MY, Huang, SW, Wang, YC, Hou, MH, Chen, CJ, Chen, Y. Structural insights into signaling promiscuity of the CBASS anti-phage defense system from a radiation-resistant bacterium. Int J Biol Macromol. 2025;295 :139534. doi: 10.1016/j.ijbiomac.2025.139534. PubMed PMID:39761885
3. Fang, WZ, Palanisamy, S, Vijayaraghavan, P, Chen, CY, Weng, SL, Yang, CS, Wang, YM. Construction of in situ modulated controlled growth of MOF-on-mof impedimetric assembly for the practical minimal level assessment of anti-mullerian hormone. Biosens Bioelectron. 2025;272 :117113. doi: 10.1016/j.bios.2024.117113. PubMed PMID:39754847
4. Ko, HJ, Chen, SM, Yang, CS. [The Effects of a Digital Multimedia Foot Ulcer Care Program on Health Beliefs and Self-Care Behaviors in People With Diabetic Foot Ulcer]. Hu Li Za Zhi. 2024;71 (6):59-71. doi: 10.6224/JN.202412_71(6).08. PubMed PMID:39618136
5. Warinhomhoun, S, Raiputta, J, Rangsee, PN, Yang, CS, Chueamchaitrakun, P. Effect of Ultrasound-Assisted Extraction and Drying Methods on Bioactive Compounds, Phenolic Composition, and Antioxidant Activity of Assam Tea Cultivar (Camellia sinensis var. assamica) Cultivated in Thailand. Adv Pharmacol Pharm Sci. 2024;2024 :5772961. doi: 10.1155/2024/5772961. PubMed PMID:39512303 PubMed Central PMC11540878
6. Chen, CC, Yen, TH, Li, JR, Chen, CJ, Yang, CS, Lai, JY, Lin, SJ, Yeh, CH, Hsu, SW, Lin, MY et al.. Artificial intelligence algorithms enhance urine cytology reporting confidence in postoperative follow-up for upper urinary tract urothelial carcinoma. Int Urol Nephrol. 2024; :. doi: 10.1007/s11255-024-04270-8. PubMed PMID:39509034
7. Chang, KY, Yang, CS, Lai, JY, Lin, SJ, Li, JR, Liu, TJ, Yang, WL, Lin, MY, Yeh, CH, Hsu, SW et al.. An Artificial Intelligence-assisted Diagnostic System Improves Upper Urine Tract Cytology Diagnosis. In Vivo. 2024;38 (6):3016-3021. doi: 10.21873/invivo.13785. PubMed PMID:39477382 PubMed Central PMC11535956