Biographical Info

Research Areas

Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.

Research Highlights

• Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
• Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
• Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
• Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
• Conducting translational research on tocopherols in prostate cancer patients.

Scholarly Activities

• Conduct research as described above.
• Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
• Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
• Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.

Recent Publications

1. Chang, KY, Yang, CS, Lai, JY, Lin, SJ, Li, JR, Liu, TJ, Yang, WL, Lin, MY, Yeh, CH, Hsu, SW et al.. An Artificial Intelligence-assisted Diagnostic System Improves Upper Urine Tract Cytology Diagnosis. In Vivo. 2024;38 (6):3016-3021. doi: 10.21873/invivo.13785. PubMed PMID:39477382
2. Yoon, C, Kim, HK, Ham, YS, Gil, WJ, Mun, SJ, Cho, E, Yuk, JM, Yang, CS. Toxoplasma gondii macrophage migration inhibitory factor shows anti-Mycobacterium tuberculosis potential via AZIN1/STAT1 interaction. Sci Adv. 2024;10 (43):eadq0101. doi: 10.1126/sciadv.adq0101. PubMed PMID:39453997 PubMed Central PMC11506136
3. Cheng, HE, Yeh, HZ, Yang, CS, Yang, SS, Liao, SC. Disseminated Cryptococcus over pancreas, lung, and brain: a case report. J Med Case Rep. 2024;18 (1):513. doi: 10.1186/s13256-024-04836-1. PubMed PMID:39438983 PubMed Central PMC11515725
4. Lu, X, He, Y, Guo, JQ, Wang, Y, Yan, Q, Xiong, Q, Shi, H, Hou, Q, Yin, J, An, YB et al.. Dynamics of epitranscriptomes uncover translational reprogramming directed by ac4C in rice during pathogen infection. Nat Plants. 2024;10 (10):1548-1561. doi: 10.1038/s41477-024-01800-1. PubMed PMID:39317771
5. Yang, CS, Tan, Z. Construction and validation of a predictive model for preoperative lower extremity deep vein thrombosis risk in elderly hip fracture patients: An observational study. Medicine (Baltimore). 2024;103 (38):e39825. doi: 10.1097/MD.0000000000039825. PubMed PMID:39312315 PubMed Central PMC11419451
6. Li, HN, Xu, XN, Qin, YH, Liu, R, Guo, WY, Huang, XY, Fan, ML, Zhang, LJ, Qi, Y, Zhang, C et al.. Clinical features of COVID-19 infection in patients with myasthenia gravis: a real-world retrospective study. Front Public Health. 2024;12 :1421211. doi: 10.3389/fpubh.2024.1421211. PubMed PMID:39257951 PubMed Central PMC11384569
7. Xu, Y, Meng, H, Fan, M, Yin, L, Sun, J, Yao, Y, Wei, Y, Cong, H, Wang, H, Song, T et al.. A Simple Score (MOG-AR) to Identify Individuals at High Risk of Relapse After MOGAD Attack. Neurol Neuroimmunol Neuroinflamm. 2024;11 (6):e200309. doi: 10.1212/NXI.0000000000200309. PubMed PMID:39250723 PubMed Central PMC11385954