Biographical Info

Research Areas

Mechanisms of carcinogenesis and its prevention, including development of new animal models for colon ad prostate cancers as well as studies on the inhibition of carcinogenesis by tea constituents, tocopherols, and their combination with commonly used drugs. Research is being conducted in animal models, on molecular investigation with cell lines, and in humans.

Research Highlights

• Development of animal models for colon and prostate cancers using humanized CYP1A mice and PhIP (a dietary carcinogen) to study dietary cancer prevention.
• Elucidation of the cancer preventive activities and mechanisms of action of green tea polyphenols.
• Demonstration of the broad cancer prevention activities of tocopherols, especially the higher activity of d-tocopherol than g-tocopherol, and the ineffectiveness of a-tocopherol.
• Elucidation of the inhibition of the interactions between cancer cells and myeloid derived suppressor cells in vivo and in vitro by curcumin.
• Conducting translational research on tocopherols in prostate cancer patients.

Scholarly Activities

• Conduct research as described above.
• Teach a course on “Diet, Nutrition and Disease Prevention in Pharmacy Practice” and lecture in the course “Molecular Biology and Pharmaceutical Biotechnology.”
• Serve as a Leader of the Carcinogenesis and Chemoprevention Program of the Cancer Institute of New Jersey.
• Serve on editorial board of several scientific journals and currently editing a special volume on “Tea and Health” for Pharmacological Research.

Recent Publications

1. Liu, C, Chen, J, Che, Y, He, L, Luo, S, Yang, CS, Chen, T. Interactive Effects of Arabinoxylan Oligosaccharides and Green Tea Polyphenols on Obesity Management and Gut Microbiota Modulation in High-Fat Diet-Fed Mice. J Agric Food Chem. 2024; :. doi: 10.1021/acs.jafc.4c02022. PubMed PMID:38984620
2. Hou, MH, Chen, CJ, Yang, CS, Wang, YC, Chen, Y. Structural and functional characterization of cyclic pyrimidine-regulated anti-phage system. Nat Commun. 2024;15 (1):5634. doi: 10.1038/s41467-024-49861-2. PubMed PMID:38965224 PubMed Central PMC11224242
3. Yang, CS, Geng, JH, Wu, PY, Huang, JC, Hu, HM, Chen, SC, Kuo, CH. Sex difference in the associations among hyperuricemia with self-reported peptic ulcer disease in a large Taiwanese population study. Front Med (Lausanne). 2024;11 :1383290. doi: 10.3389/fmed.2024.1383290. PubMed PMID:38919943 PubMed Central PMC11197382
4. Hong, D, Kim, HK, Yang, W, Yoon, C, Kim, M, Yang, CS, Yoon, S. Integrative analysis of single-cell RNA-seq and gut microbiome metabarcoding data elucidates macrophage dysfunction in mice with DSS-induced ulcerative colitis. Commun Biol. 2024;7 (1):731. doi: 10.1038/s42003-024-06409-w. PubMed PMID:38879692 PubMed Central PMC11180211
5. Husain, K, Coppola, D, Yang, CS, Malafa, MP. Effect of vitamin E δ-tocotrienol and aspirin on Wnt signaling in human colon cancer stem cells and in adenoma development in APCmin/+ mice. Carcinogenesis. 2024; :. doi: 10.1093/carcin/bgae041. PubMed PMID:38877828
6. Gibbs, KW, Semler, MW, Driver, BE, Seitz, KP, Stempek, SB, Taylor, C, Resnick-Ault, D, White, HD, Gandotra, S, Doerschug, KC et al.. Noninvasive Ventilation for Preoxygenation during Emergency Intubation. N Engl J Med. 2024;390 (23):2165-2177. doi: 10.1056/NEJMoa2313680. PubMed PMID:38869091
7. Ivanesthi, IR, Latifah, E, Amrullah, LF, Tseng, YK, Chuang, TH, Pan, HC, Yang, CS, Liu, SY, Wang, CC. Adaptation of a eukaryote-like ProRS to a prokaryote-like tRNAPro. Nucleic Acids Res. 2024;52 (12):7158-7170. doi: 10.1093/nar/gkae483. PubMed PMID:38842939 PubMed Central PMC11229370