Biographical Info

Research Areas

Mechanisms of hepatotoxicity caused by lipopolysaccharide or acetaminophen, including cellular and molecular effects on isolated hepatocytes, liver macrophages and endothelial cells; characterization of subpopulations of liver macrophages and endothelial following toxicant injury; modulating the immune response to hepatotoxicants to modify liver injury by using knockout mice; and mechanisms of tissue repair following toxicant-induced injury.

Research Highlights

• Studies on polarization of liver macrophage and endothelial cell populations in rats and mice following acetaminophen intoxication.
• Examination of drug interactions in mice treated with acetaminophen and an anthelminthic drug.
• Effects of loss of caveolin on acetaminophen hepatotoxicity in mice.

Recent Publications

1. Malaviya, R, Gardner, CR, Rancourt, RC, Smith, LC, Abramova, EV, Vayas, KN, Gow, AJ, Laskin, JD, Laskin, DL. Lung injury and oxidative stress induced by inhaled chlorine in mice is associated with proinflammatory activation of macrophages and altered bioenergetics. Toxicol Appl Pharmacol. 2023;461 :116388. doi: 10.1016/j.taap.2023.116388. PubMed PMID:36690086 PubMed Central PMC9960611
2. Radbel, J, Meshanni, JA, Gardner, CR, Le-Hoang, O, Cervelli, J, Laskin, JD, Gow, AJ, Laskin, DL. Novel method to assess resident alveolar macrophage efferocytosis of apoptotic neutrophils by flow cytometry. Toxicol Appl Pharmacol. 2023;460 :116359. doi: 10.1016/j.taap.2022.116359. PubMed PMID:36565939 PubMed Central PMC9870943
3. Torres, M, Carranza, C, Sarkar, S, Gonzalez, Y, Osornio Vargas, A, Black, K, Meng, Q, Quintana-Belmares, R, Hernandez, M, Angeles Garcia, JJF et al.. Urban airborne particle exposure impairs human lung and blood Mycobacterium tuberculosis immunity. Thorax. 2019;74 (7):675-683. doi: 10.1136/thoraxjnl-2018-212529. PubMed PMID:31036772 PubMed Central PMC7162557
4. Chmielowski, RA, Abdelhamid, DS, Faig, JJ, Petersen, LK, Gardner, CR, Uhrich, KE, Joseph, LB, Moghe, PV. Athero-inflammatory nanotherapeutics: Ferulic acid-based poly(anhydride-ester) nanoparticles attenuate foam cell formation by regulating macrophage lipogenesis and reactive oxygen species generation. Acta Biomater. 2017;57 :85-94. doi: 10.1016/j.actbio.2017.05.029. PubMed PMID:28522412 PubMed Central PMC5546209
5. Xu, D, Wang, H, Gardner, C, Pan, Z, Zhang, PL, Zhang, J, You, G. The role of Nedd4-1 WW domains in binding and regulating human organic anion transporter 1. Am J Physiol Renal Physiol. 2016;311 (2):F320-9. doi: 10.1152/ajprenal.00153.2016. PubMed PMID:27226107 PubMed Central PMC5243221
6. Mandal, M, Gardner, CR, Sun, R, Choi, H, Lad, S, Mishin, V, Laskin, JD, Laskin, DL. The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury. Toxicol Appl Pharmacol. 2016;304 :110-20. doi: 10.1016/j.taap.2016.04.019. PubMed PMID:27163765 PubMed Central PMC5147741
7. Jan, YH, Heck, DE, Dragomir, AC, Gardner, CR, Laskin, DL, Laskin, JD. Acetaminophen reactive intermediates target hepatic thioredoxin reductase. Chem Res Toxicol. 2014;27 (5):882-94. doi: 10.1021/tx5000443. PubMed PMID:24661219 PubMed Central PMC4033643
8. Massa, CB, Scott, P, Abramova, E, Gardner, C, Laskin, DL, Gow, AJ. Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction. Toxicol Appl Pharmacol. 2014;278 (1):53-64. doi: 10.1016/j.taap.2014.02.006. PubMed PMID:24582687 PubMed Central PMC4361901
9. Liu, Y, Gardner, CR, Laskin, JD, Laskin, DL. Classical and alternative activation of rat hepatic sinusoidal endothelial cells by inflammatory stimuli. Exp Mol Pathol. 2013;94 (1):160-7. doi: 10.1016/j.yexmp.2012.10.015. PubMed PMID:23103612 PubMed Central PMC3562401
10. Gardner, CR, Hankey, P, Mishin, V, Francis, M, Yu, S, Laskin, JD, Laskin, DL. Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase. Toxicol Appl Pharmacol. 2012;262 (2):139-48. doi: 10.1016/j.taap.2012.04.027. PubMed PMID:22575169 PubMed Central PMC3377817