Controlled Exposure


Controlled Environment Chamber


  • To provide capabilities for:
    • controlled inhalation/topical human exposure – response studies
    • biomarker performance studies
  • To provide expertise on generation of exposure conditions for innovative human exposure studies
  • To generate gaseous and particle concentrations for durations and situations relevant to environmental and occupational exposures
  • To provide consultation on exposure generation and chamber development

Human Study Requirements

  • Simulate typical environmental/occupational situations
  • Develop and validate exposure generation protocols for compounds or mixtures.
  • Ensure that variables and methods are appropriate for project hypotheses and conform to IRB criteria.


  • Uses pollutant generation systems (volatile and particulate matter) to provide constant or preset varying concentrations
  • Diesel particle delivery system
  • Controlled environmental conditions: temperature 55 to 80 ± 1°F and relative humidity 15 to 80% ± 2%, ventilation rates (2-15 air changes per hour)
  • Designed to mimic typical human environmental situations as well as environmentally relevant concentrations
  • Monitors for ozone (O3), total hydrocarbon analyzer (THC), nitrogen oxides (NOx), hydrogen sulfide (H2S), carbon monoxide (CO), PM2.5 or PM10 mass monitors, fine and ultra-fine particulate counters to measure particle number concentration and size distribution.
  • Can support blood draws, physiological measurements and reaction rate responses
  • Medical staff on-call

170 Frelinghuysen Road, Piscataway, NJ 08854 – 848-445-0200  Fax: 732-445-0131

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