Controlled Exposure

chamber

Goals:

- controlled inhalation/topical human exposure – response studies
- biomarker performance studies
To provide expertise on generation of exposure conditions for innovative human exposure studies
To generate gaseous and particle concentrations for durations and situations relevant to environmental and occupational exposures
To provide consultation on exposure generation and chamber development

Human Study Requirements

Simulate typical environmental/occupational situations
Develop and validate exposure generation protocols for compounds or mixtures.
Ensure that variables and methods are appropriate for project hypotheses and conform to IRB criteria.

Capabilities

Uses pollutant generation systems (volatile and particulate matter) to provide constant or preset varying concentrations
Diesel particle delivery system
Controlled environmental conditions: temperature 55 to 80 ± 1°F and relative humidity 15 to 80% ± 2%, ventilation rates (2-15 air changes per hour)
Designed to mimic typical human environmental situations as well as environmentally relevant concentrations
Monitors for ozone (O3), total hydrocarbon analyzer (THC), nitrogen oxides (NOx), hydrogen sulfide (H2S), carbon monoxide (CO), PM2.5 or PM10 mass monitors, fine and ultra-fine particulate counters to measure particle number concentration and size distribution.
Can support blood draws, physiological measurements and reaction rate responses
Medical staff on-call

170 Frelinghuysen Road, Piscataway, NJ 08854 – 848-445-0200 Fax: 732-445-0131