EOHSI

Biographical Info

Dr. Zarbl serves as the Director of the NIEHS sponsored Center for Environmental Exposures and Disease. He is also the Associate Director For Public Health Sciences at the Cancer Institute of New Jersey. He serves on numerous national research review and advisory panels, and editorial panels.. Dr. Zarbl is known for his work in areas of toxicogenomics, and mechanisms of and genetic susceptibility to chemical carcinogenesis, mechanisms of mutagenesis and toxicity, and technology development. These research efforts have to date resulted in over 70 scientific papers and book chapters.

Research Areas

Research has focused largely on toxicogenomics and functional genomics, carcinogenesis, molecular and cellular biology, and toxicology. Specifically this has included work understand to molecular mechanisms of chemical carcinogenesis and the genetic basis for differential susceptibility to mammary carcinogenesis using animal and in vitro model systems, and then translating the findings to human breast cancer.

Research Highlights

Studies in the rat model have included analysis of oncogene activation, mechanisms of signal transduction, and genetic linkage analysis to identify mammary tumor suppressor genes. He has also used toxicogenomics to dissect mechanisms of mechanism carcinogenesis, tumor progression and chemoprevention. His studies in the area of toxicogenomics include the development and application of standards for DNA microarray experiments, and phenotypic anchoring of response of human cells, model organisms (yeast) and target organs (rodents) to toxicants, providing insights into dose and temporal responses, as well as mechanisms of action. He is also actively involved in technology development for functional genomics and biomarker screening.

Recent Publications

1. Fang, M, Kang, HG, Park, Y, Estrella, B, Zarbl, H. In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells. J Vis Exp. 2017; (127):. doi: 10.3791/55832. PubMed PMID:28994762
2. Green, AL, Zhan, L, Eid, A, Zarbl, H, Guo, GL, Richardson, JR. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology. 2017;125 :189-196. doi: 10.1016/j.neuropharm.2017.07.020. PubMed PMID:28743636 PubMed Central PMC5585058
3. Fang, M, Ohman Strickland, PA, Kang, HG, Zarbl, H. Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis. Oncotarget. 2017;8 (20):32752-32768. doi: 10.18632/oncotarget.15678. PubMed PMID:28427145 PubMed Central PMC5464825
4. Sunil, VR, Vayas, KN, Fang, M, Zarbl, H, Massa, C, Gow, AJ, Cervelli, JA, Kipen, H, Laumbach, RJ, Lioy, PJ et al.. World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung. Exp. Mol. Pathol. 2017;102 (1):50-58. doi: 10.1016/j.yexmp.2016.12.005. PubMed PMID:27986442 PubMed Central PMC5472054
5. Klaene, JJ, Flarakos, C, Glick, J, Barret, JT, Zarbl, H, Vouros, P. Tracking matrix effects in the analysis of DNA adducts of polycyclic aromatic hydrocarbons. J Chromatogr A. 2016;1439 :112-23. doi: 10.1016/j.chroma.2015.10.057. PubMed PMID:26607319 PubMed Central PMC4789121
6. Fang, M, Guo, WR, Park, Y, Kang, HG, Zarbl, H. Enhancement of NAD?-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells. Oncotarget. 2015;6 (40):42879-91. doi: 10.18632/oncotarget.6002. PubMed PMID:26544624 PubMed Central PMC4767478
7. Fang, MZ, Ohman-Strickland, P, Kelly-McNeil, K, Kipen, H, Crabtree, BF, Lew, JP, Zarbl, H. Sleep interruption associated with house staff work schedules alters circadian gene expression. Sleep Med. 2015;16 (11):1388-1394. doi: 10.1016/j.sleep.2015.06.011. PubMed PMID:26498241 PubMed Central PMC4621493