Ioannis Androulakis Ph.D. » EOHSI Directory


Ioannis Androulakis Ph.D.

Professor Rutgers University – School of EngineeringEOHSI – Exposure Science
Address BME Building Room 212 599 Taylor Road Piscataway NJ 08854 Phone: 848-445-6561 Fax: 732-445-3753
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Biographical Info

Dr. Androulakis received his B.S. in Chemical Engineering from the National Technical University of Athens, Greece, and he subsequently obtained his M.S and Ph.D. from Purdue University, USA. He spent two years at Princeton University as a research associate before joining ExxonMobil’s Corporate Strategic Research Laboratories, where he eventually became the Informatics and Knowledge Capitalization technical project leader before joining the Departments of Biomedical Engineering and Chemical & Biochemical Engineering at Rutgers University. His work has been funded by the US Environmental Protection Agency, the National Science Foundation, the Office of Naval Research, and the National Institutes of Health.

Dr. Androulakis actively pursues research activities in the area of Systems Biology, loosely defined as an integrative modeling and experimental framework that approaches biological entities as “systems” in the physical and engineering sense. Of particular interest are issues related to “functional physiomics” in an attempt to establish functional links between cellular events, such as signaling, transcription and translation, and an expanding envelope of interactions which include the bidirectional links between cells, tissues, organs, environmental signals and physiological responses. The ultimate goal is to develop in silico methodologies that will enable translational research by elucidating putative mechanisms by which macroscopic responses, at the physiome level, can be functionally modulated through mechanistic interventions. Of particular importance are the opportunities of such an integrative approach applied to the inflammatory responses due to the critical role inflammation plays in a number of physiologically and clinically relevant situations. His work integrates a compendium of experimental systems, from cell cultures, to animal models, to human studies in order to address different questions at their appropriate level of detail.

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Recent Publications

  1. Kamisoglu, K, Acevedo, A, Almon, RR, Coyle, S, Corbett, S, Dubois, DC, Nguyen, TT, Jusko, WJ, Androulakis, IP. Understanding Physiology in the Continuum: Integration of Information from Multiple -Omics Levels. Front Pharmacol. 2017;8 :91. doi: 10.3389/fphar.2017.00091. PubMed PMID:28289389 PubMed Central PMC5327699
  2. Hartmanshenn, C, Scherholz, M, Androulakis, IP. Physiologically-based pharmacokinetic models: approaches for enabling personalized medicine. J Pharmacokinet Pharmacodyn. 2016;43 (5):481-504. doi: 10.1007/s10928-016-9492-y. PubMed PMID:27647273 PubMed Central PMC5204363
  3. Androulakis, IP. Quantitative Systems Pharmacology: A Framework for Context. Curr Pharmacol Rep. 2016;2 (3):152-160. doi: 10.1007/s40495-016-0058-x. PubMed PMID:27570730 PubMed Central PMC4996481
  4. Pierre, K, Schlesinger, N, Androulakis, IP. The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity. Physiol. Genomics. 2016;48 (10):719-738. doi: 10.1152/physiolgenomics.00006.2016. PubMed PMID:27341833 PubMed Central PMC5243227
  5. Rao, R, Yang, Q, Orman, MA, Berthiaume, F, Ierapetritou, MG, Androulakis, IP. Burn trauma disrupts circadian rhythms in rat liver. Int J Burns Trauma. 2016;6 (2):12-25. . PubMed PMID:27335693 PubMed Central PMC4913229
  6. Rao, R, Orman, MA, Berthiaume, F, Androulakis, IP. Dynamics of hepatic gene expression and serum cytokine profiles in single and double-hit burn and sepsis animal models. Data Brief. 2015;3 :229-33. doi: 10.1016/j.dib.2015.02.018. PubMed PMID:26217749 PubMed Central PMC4510136
  7. Wu, TY, Huang, Y, Zhang, C, Su, ZY, Boyanapalli, S, Khor, TO, Wang, H, Lin, H, Gounder, M, Kagan, L et al.. Pharmacokinetics and pharmacodynamics of 3,3'-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes. J Pharmacokinet Pharmacodyn. 2015;42 (4):401-8. doi: 10.1007/s10928-015-9421-5. PubMed PMID:26138223
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