Howard Kipen MD, MPHInterim Chair and Professor, Chief, CROM Division, Associate Director EOHSI Rutgers University – School of Public HealthEOHSI – Clinical Research and Occupational Medicine
Dr. Kipen’s research focuses on clinical and epidemiological studies of the health effects of ambient air pollution. He works closely with Rob Laumbach of the CROM division as well as Qingyu Meng of Exposure Science and Debra Laskin and Andrew Gow of Toxicology. They use both controlled exposure models with ozone, fresh aerosols, and diesel-enriched on-road exposures, primarily with drives on the New Jersey Turnpike. A new EPA study examines health benefits of portable air cleaners for reducing indoor air pollution levels. Biomarker outcomes presently emphasized are exhaled breath oxidative stress and invasive and noninvasive measures of vascular function.
With former EOHSI members Jim Zhang and David Rich, we conducted a panel study of 130 Beijing medical students built around the Chinese Government’s drastic reductions in air pollution during the 2008 Olympics. We observed broad declines in multiple oxidative stress, inflammatory, and platelet activation biomarkers. Major results have been published in JAMA and the American Journal of Respiratory and Critical Care Medicine with multiple subsidiary papers and a complete report published by the Health Effects Institute. Related effects have been shown with New Jersey air pollution on the Turnpike and are being evaluated with air cleaners in individual homes.
Significant declines in proteasome (UPP) activity after exposure to secondary organic aerosol and diesel exhaust were observed immediately following exposure in healthy subjects.
The above declines in proteasome activity showed a significant interaction (3-fold increase) in subjects with the ILE/ILE polymorphism of GSTP1.
- Chair, NASA Human Research Program’s Advanced Environmental Health / Advanced Food Technology Standing Review Panel
- Member, National Academies Standing Committee on Medical and Epidemiological Aspects of Air Pollution on U.S. Government Employees and their Families, 2016
- Chair / Member Multiple Ad Hoc Grant Review Panels (e.g., NIEHS, Department of Defense)
- Governor’s Appointee, Public Employee’s Occupational Safety and Health Review Commission, New Jersey Department of Labor
- Member, Public Health Scientific Advisory Board, New Jersey Department of Environmental Protection
- Thurston, GD, Kipen, H, Annesi-Maesano, I, Balmes, J, Brook, RD, Cromar, K, De Matteis, S, Forastiere, F, Forsberg, B, Frampton, MW et al.. A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework. Eur. Respir. J. 2017;49 (1):. doi: 10.1183/13993003.00419-2016. PubMed PMID:28077473
- Sunil, VR, Vayas, KN, Fang, M, Zarbl, H, Massa, C, Gow, AJ, Cervelli, JA, Kipen, H, Laumbach, RJ, Lioy, PJ et al.. World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung. Exp. Mol. Pathol. 2017;102 (1):50-58. doi: 10.1016/j.yexmp.2016.12.005. PubMed PMID:27986442 PubMed Central PMC5472054
- Patton, AP, Laumbach, R, Ohman-Strickland, P, Black, K, Alimokhtari, S, Lioy, P, Kipen, HM. Scripted drives: A robust protocol for generating exposures to traffic-related air pollution. Atmos Environ (1994). 2016;143 :290-299. doi: 10.1016/j.atmosenv.2016.08.038. PubMed PMID:27642251 PubMed Central PMC5019181
- Altemose, B, Robson, MG, Kipen, HM, Ohman Strickland, P, Meng, Q, Gong, J, Huang, W, Wang, G, Rich, DQ, Zhu, T et al.. Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress. J Expo Sci Environ Epidemiol. 2017;27 (3):244-250. doi: 10.1038/jes.2016.38. PubMed PMID:27436693
- Pettit, AP, Kipen, H, Laumbach, R, Ohman-Strickland, P, Kelly-McNeill, K, Cepeda, C, Fan, ZH, Amorosa, L, Lubitz, S, Schneider, S et al.. Disrupted Nitric Oxide Metabolism from Type II Diabetes and Acute Exposure to Particulate Air Pollution. PLoS ONE. 2015;10 (12):e0144250. doi: 10.1371/journal.pone.0144250. PubMed PMID:26656561 PubMed Central PMC4682772
- Son, Y, Mishin, V, Welsh, W, Lu, SE, Laskin, JD, Kipen, H, Meng, Q. A Novel High-Throughput Approach to Measure Hydroxyl Radicals Induced by Airborne Particulate Matter. Int J Environ Res Public Health. 2015;12 (11):13678-95. doi: 10.3390/ijerph121113678. PubMed PMID:26516887 PubMed Central PMC4661607
- Fang, MZ, Ohman-Strickland, P, Kelly-McNeil, K, Kipen, H, Crabtree, BF, Lew, JP, Zarbl, H. Sleep interruption associated with house staff work schedules alters circadian gene expression. Sleep Med. 2015;16 (11):1388-94. doi: 10.1016/j.sleep.2015.06.011. PubMed PMID:26498241 PubMed Central PMC4621493