Jason R. Richardson M.S., Ph.D., DABT
EOHSI Room 340
170 Frelinghuysen Road
Department of Environmental & Occupational Medicine
Robert Wood Johnson Medical School
Piscataway, NJ 08854
Jason Richardson, M.S., Ph.D. DABT is a tenured Associate Professor and Board Certified Toxicologist in the Department of Environmental and Occupational Medicine at Rutgers Robert Wood Johnson Medical School and Resident Member of the Environmental and Occupational Health Sciences Institute. He received his M.S. (1999) and Ph.D. (2002) degrees from Mississippi State University where he conducted research on mixtures of organophosphate pesticides and the developmental neurotoxicity of organophosphates. He then completed postdoctoral training in Molecular Neuroscience at Emory University (2002-2005) where he focused on the role of pesticide exposure in Parkinson’s disease. His research at EOHSI focuses on the role of environmental exposures and their interactions with genetic susceptibility as contributors to neurological disease using translational approaches. Dr. Richardson has authored or co-authored over 60 publications that have been cited over 2,000 times in the areas of developmental neurotoxicology, neurodegenerative disease, and pesticides. He has received the Outstanding New Environmental Scientist Award from the National Institute of Environmental Health Sciences and a Young Scientist Award from the American Society for Pharmacology and Experimental Therapeutics. Dr. Richardson is currently a member of the Editorial boards of Toxicological Sciences and Neurotoxicology, Neurotoxicology and Teratology, and was an Associate Editor for BMC Neurology. He has served as a grant reviewer for several NIH panels, the Michael J. Fox Foundation for Parkinson’s Disease Research, Health Canada, and the United Kingdom Parkinson’s Disease Society. He also served the Society of Toxicology as Secretary/Treasurer of the Neurotoxicology Specialty Section for two years.
In general, the goals of our research are three-fold:
susceptibility in the etiology of neurological disease.
therapeutic agents in these models
of the nervous system.
More specifically, our research is currently focused on the role of pesticide exposures in the etiology and pathogenesis of Attention-deficit hyperactivity disorder (ADHD), Parkinson’s disease (PD), and Alzheimer’s Disease (AD). To accomplish our research goals, we make use of a variety of research techniques spanning from in vitro cell culture models to in vivo animal models and human populations and from molecular techniques to whole animal behavioral techniques.
2014-present: Member National Institute of Environmental Health Sciences Review Committee
2014-present: Member National Academy of Science Comittee on Emerging Science for Environmental Health Decisions
2009-present: Editorial Board Member Neurotoxicology
2009-2013: Associate Editor BMC Neurology
2010-present: Editorial Board Member Toxicological Sciences
2010-present: Editorial Board Member Current Molecular Pharmacology
2009: NIH Expert Panel Workshop on Toxic Industrial Chemicals (July 22-23, 2009), Bethesda, MD.
2010: NIH/NIEHS Brainstorming Panel on Autism and the Environment (September 8, 2010), Research Triangle Park, NC
2010: Co-Chair, 2010; 26th International Neurotoxicology Conference
2011-present: Editorial Board Member Neurotoxicology and Teratology
2011: Editor, Special Issue Neurotoxicology
2013-present: Editorial Board Member Toxics
Dr. Richardson's Google Scholar Page:
Hossain, M.M, DiCicco-Bloom, E., and Richardson, J.R.# (2015). Hippocampal ER stress and Deficits in Learning and Memory Following Repeated Pyrethroid Exposure. Toxicol. Sci. 143: 220-228.
Masoud, S.T., Vecchio, L.M., Bergeron, Y., Hossain, M.M., Bermejo, M.K., Kile, B., Sotnikova, T.D., Siesser, W.B., Gainetdinov, R.R., Wightman, R.M., Caron, M.G., Richardson, J.R., Miller, G.W., Ramsey, A.J., Cyr M., and Salahpour, A. (2015). Increased Expression of the Dopamine Transporter Induces Degeneration of Dopamine Neurons. Neurobiol. Dis. 74: 66-75.
^Magby, J., Richardson, J.R.#. (2015). Role of Calcium and Calpain in the Down-Regulation of Voltage Gated Sodium Expression by the Pyrethroid Pesticide Deltamethrin. Epub Oct 30 2014; J Biochem Mol Toxicol.
Eyo, U.B., Gu, N., De, S., Dong, H., Richardson, J.R., and Wu, L.J. (2015). Modulation of Microglial Process Convergence towards Neuronal Dendrites by Extracellular Calcium. In Press J. Neurosci.
Yang, S., Jan, Y.H., Mishin, V., Richardson, J.R., Hossain, M.M., Heindel, N.D., Heck, D.E., Lasking, D.L., and Laskin, J.D. (2015). Sulfa Drugs Inhibit Sepiapterin Reduction and Chemical Redox Cycling by Sepiapterin Reductase. Epub Dec 30, 2014. J Pharmacol Exp Ther.
Richardson, J.R.#, Taylor, M.M., Shalat, S.L., Guillot, T.S., Caudle, W.M., Hossain, M.M., Mathews, T.A., Jones, S.R., Cory-Slechta, D.A., and Miller, G.W. (2015). Developmental Pesticide Exposure Reproduces Features of Attention-Deficit Hyperactivity Disorder. In Press FASEB J.
Kong, B., Huang, J., Zhu, Y., Li, G., Williams, U.A., Shen, S., Aleksunes, L.M., Richardson, J.R., Apte, U., Rudnick, D.A., and Guo, G.L. (2014). Fibroblast Growth Factor 15 Deficiency in Mice Impairs Liver Regeneration. Am J Physiol Gastrointest Liver Physiol. 306: G893-902.
Zheng, R., Dragomir, A.C., Mishin, V., Richardson, J.R., Heck, D.E., Laskin, D.L., and Laskin, J.D. (2014). Differential Metabolism of 4-hydroxynonenal in Liver, Lung and Brain of Mice and Rats. Toxicol Appl Pharmacol. 279: 43-52.
Wen, X., Gibson, C.J., Yang, I., Buckley, B., Goedken, M., Richardson, J.R., and Aleksunes, L. (2014). MDR1 Transporter Protects Against Paraquat-Induced Toxicity in Human and Mouse Proximal Tubule Cells. Toxicol. Sci. 141: 475-483. Editor’s Highlighted Article
Richardson, J.R.#, Roy, A., Shalat, S.L., ^von Stein, R.T., Hossain, M.M., Buckley, B.B., Gearing, M., Levey, A.I., and German D.C. (2014). Serum Pesticide Levels and Increased Risk for Alzheimer Disease. JAMA Neurol. 71:284-90.
Yochum, C., Doherty-Lyon, S., Hoffman, C., Hossain, M.M., Zelikoff, J.T., and Richardson, J.R.# (2014). Prenatal Cigarette Smoke Exposure Causes Hyperactivity and Aggressive Behaviors: Role of Catecholamines and Neurotrophins. Exp Neurol. 254: 145-152.
Inamdar, A.A., Masurekar, P., Hossain, M.M., Richardson, J.R., and Bennett, J.W. (2014). Signaling Pathways Involved in 1-Octen-3-ol-Mediated Neurotoxicity in Drosophila melanogaster: Implication in Parkinson’s Disease. Neurotox Res. 25: 183-191.
Meng, Y., Sohar, I., Sleat, D.E., Richardson, J.R., Reuhl, K.R., Jenkins, R.B., Sarkar, G., and Lobel, P. (2014). Effective Intravenous Therapy for Neurodegenerative Disease with a Therapeutic Enzyme and a Peptide that Mediates Delivery to the Brain. Mol Ther. 22:547-53.
Kong, B., Huang, J., Zhu, Y., Li, G., Williams, U.A., Shen, S., Aleksunes, L.M., Richardson, J.R., Apte, U., Rudnick, D.A., and Guo, G.L. (2014). Fibroblast Growth Factor 15 Deficiency in Mice Impairs Liver Regeneration. Am J Physiol-Gastr Liv Physiol. Epub April 3.
Sonsalla, P.K., Coleman, C., Wong, L.Y., Harris, S.L., Richardson, J.R., Gadad, B., Li, W., and German, D.C. (2013). The Angiotensin Converting Enzyme Inhibitor Captopril Protects Nigrostriatal Dopamine Neurons in Animal Models of Parkinson’s Disease. Exp. Neurol. 250: 376-83.
Inamdar, A.A., Hossain, M.M., Bernstein, A.I., Miller, G.W., Richardson J.R., and Bennett, J. (2013). Fungal volatile organic compounds: Potential environmental agents for the pathogenesis of Parkinson’s disease. Proceedings of the National Academy of Sciences USA 110: 19561-6.
Richardson, J.R., and Hossain, M.M. (2013). Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease. Neural Plasticity 587418
Hossain, M.M., Sonsalla, P.K., and Richardson, J.R.(2013). Coordinated role of voltage-gated sodium channel and the Na+/H+ exchanger in sustaining microglial activation during inflammation. Toxicol Appl Pharmacol. 273: 355-364.
Bradner, J., Suragh, T., Wilson, W., Lazo, C., Stout, K., Kim H.M., Wang, M., Walker, D., Pennell, K.D., Richardson, J.R., Miller, G.W., and Caudle, W.M. (2013). Exposure to the Polybrominated Diphenyl Ether Mixture DE-71 Damages the Nigrostriatal Dopamine System: Role of Dopamine Handling in Neurotoxicity. Exp Neurol. 241: 138-47.
Fortin, M.C., Aleksunes, L.M., and Richardson, J.R.(2013). Alteration of the Expression of Pesticide-Metabolizing Enzymes in Pregnant Mice: Potential Role in the Increased Vulnerability of the Developing Brain. Drug Metab Disp. 41: 326-31.
Bircsak, K.M., Richardson, J.R*,., and Aleksunes, L.M*. (2013). Inhibition of Human MDR1 and BCRP Transporter ATPase Activity by Organochlorine and Pyrethroid Insecticides. J Biochem Mol Toxicol. 27: 157-64.
Hossain, M.M., Suzuki, T., Richardson, J.R., and Kobayashi, H. (2013). Acute Effects of Type I and Type II Pyrethroids on Serotonin Release in the Striatum of Awake Rats: An in vivo microdialysis study. J Biochem Mol Toxicol. 27: 150-6.
Armstrong, L., Driscoll, M.V., Donepudi, A.C., Xu, J., ^Baker, A.B., Aleksunes, L.M., Richardson, J.R., and Slitt, A.L. (2013). Effects of Developmental Deltamethrin Exposure on White Adipose Tissue Gene Expression and Weight. J Biochem Mol Toxicol. 27: 165-71.
Sheleg, M., Yochum, Y.L., Wagner, G.C., Zhou, R., and Richardson, J.R.(2013). Ephrin-A5 Deficiency Alters Sensorimotor and Monaminergic Development. Behav Brain Res. 236: 139-147.
Gibson, C.J., Hossain, M.M., Richardson, J.R.*, and Aleksunes, L.M*. (2012). Inflammatory Regulation of ABC Efflux Transporter Expression and Function in Microglia. J Pharmacol Exp Ther. 343: 650-660.
Sonsalla, P.K., Wong, L.Y., Harris, S.L., Richardson, J.R., Khobahy, I., Li, W., Gadad, B.S., and German, D.C. (2012). Delayed Caffeine Treatment Prevents Nigral Dopamine Neuron Loss in a Progressive Rat Model of Parkinson’s Disease. Exp Neurol. 234: 482-487.
Peltier, M.R., Klimova, N.G., Arita, Y., Gurzenda, E.M., Murthy, A., Chawala, K., Lerner, V., Richardson, J., and Hanna, N. (2012). Polybrominated Diphenyl Ethers Enhance the Production of Proinflammatory Cytokines by the Placenta. Placenta 33: 741-744.
Selected Published Book Chapters
Snyder, R. and Richardson, J.R. (2009). Education of the Toxicologist and Career Prospects. In General and Applied Toxicology (B. Ballantyne, T. Marrs, and T. Syversen, eds.) John Wiley & Sons. In Press.
Jett, D.A., and Richardson, J.R. (2009). Pesticide Exposure and Neurological Disease. In Clinical Neurotoxicology: Syndromes, Substances, and Environments. (M. Dobbs, ed.) Elsevier, San Diego, pp. 491-499.
Richardson, J.R. and Miller, G.W. (2010). Toxicology in Environmental Health. In Environmental Health: From Global to Local (H. Frumkin, ed.), Jossey-Bass.
Magby, J. and Richardson, J.R. (2011). Selective Vulnerability in the Nervous System. In Comprehensive Toxicology: Neurotoxicology (M. Philbert, ed). Elsevier. Pp. 29-38.
Baker, A., Taylor, M.M, and Richardson, J.R. (2011). Environmental Factors in Attention Deficit Hyperactivity Disorder. In Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies and Mechanisms (W. Slikker Jr. and C Chang, eds). John Wiley and Sons. Pp. 257-274.
Beier, E. and Richardson, J.R. (2014) Parkinson’s Disease Mechanisms and Biological Plausibility: Animal and In Vitro Studies on Dopaminergic Neurotoxicants. In Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. Elsevier, San Diego.