Maternal-child environmental health lab

The Maternal-Child Environmental Health Lab examines the impact of environmental chemicals and psychosocial stressors on pregnancy and child development. We focus on pregnancy because exposures during early life (including gestation) can have profound and long-lasting impacts on health and development across the lifespan.  Much of our work focuses on endocrine disrupting chemicals that interfere with the typical hormone environment during pregnancy, such as phthalates, per- and polyfluoroalkyl substances, and mycoestrogens. Through our ongoing pregnancy cohort studies, we hope to improve our understanding of how these widespread exposures affect our bodies and ultimately, improve maternal and child health.


Understanding Pregnancy Signals and Infant Development is an ongoing prospective birth cohort designed to study maternal prenatal psychological distress and child health. UPSIDE’s key design elements including (1) serial maternal questionnaire and biomarker data across all trimester and (2) pediatric visits at seven time points from birth to 4 years old, allow researchers to examine multiple exposures impacting maternal and child health.

UPSIDE Publications

 Cohort profile: Understanding Pregnancy Signal and Infant Development (UPSIDE): a pregnancy cohort study on prenatal exposure mechanisms for child health

Biological changes in the pregnancy-postpartum period and subsequent cardiometabolic risk-UPSIDE MOMS: A research protocol




The Infant Development and the Environment Study is a multi-center study designed to examine how everyday chemicals in food, cosmetics, and household products may affect children’s health and development. TIDES researchers are particularly interested in how the mother’s exposure to these chemicals while pregnant may affect children before they are born with changes observable during childhood and later.

TIDES Rochester

TIDES Minneapolis

TIDES San Francisco

TIDES Seattle


Recent TIDES Publications

Maternal urinary levels of glyphosate during pregnancy and anogenital distance in newborns in a US multicenter pregnancy cohort

Urinary glyphosate concentration in pregnant women in relation to length of gestation

Phthalate mixtures in pregnancy, autistic traits, and adverse childhood behavioral outcomes

Full List TIDES Publications


Environmental influences on Child Health Outcomes

The ECHO Program is an extramurally funded program maintained within the Office of the Director at the National Institutes of Health (NIH). The program aims to determine what factors give children the highest probability of achieving the best health outcomes over their lifetimes. ECHO enrolled children from previously establish cohorts and follow them over multiple life stages to understand the etiology of maternal health outcomes such as premature birth, obesity, autism, asthma and behavioral assets that strength resiliency and improve outcomes. Both UPSIDE and TIDES participate in the ECHO program. Our investigators have additional ECHO projects and participate in ECHO writing groups.

ECHO Website

ECHO related publications

Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program

The NIH ECHO Program: investigating how early environmental influences affect child health




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