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Yoke-Chen Chang Ph.D.

Assistant Research Professor Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology
Work EOHSI Room 416B 170 Frelinghuysen Rd Piscataway NJ 08854 Work Phone: 848-445-2860 Work Fax: 732-445-0119
Photo of Yoke-Chen Chang Ph.D.

Biographical Info

  • BS, National Chung-Hsing University, Taichung, Taiwan
  • MS, Rutgers University, New Brunswick, NJ
  • PhD, Rutgers University, New Bruswick, NJ
  • Post-Doc, UMDNJ/Rutgers University, Piscataway, NJ

Research Areas

My primary research area in my lab involves research involving the vesicating agent, sulfur mustard (SM). There are two basic sides to the research. The first is a basic research aspect that involves elucidating the mechanism of action of the SM. In this capacity, we are looking at the direct effect of SM on protein-protein interactions of molecules known to stabilize the skin structural integrity (eg various laminins, collagens, and their integrin receptors). We are also looking at the effects of SM on keratinocyte adhesion and migration with in vitro assays. We also have an applied research program that involves an in vivo mouse ear vesicant model. We use this model to test potential therapeutic countermeasure agents against SM-induced skin injury. We use various histological, wound repair, and gene profile analysis assays to evaluate these compounds.

Scholarly Activities

  • 2009, 2010, 2013: American Association of Anatomists (AAA) Young Faculty Travel Award, FASEB/EB
  • 2015: Best Paper of the Year Award, Society of Toxicology Annual Meeting, Dermal Specialty Section
  • 2008: Junior Investigator CounterACT Travel Award at the 2nd Annual CounterACT Network Research Symposium, Washington D.C.
  • 2009: American Association of Anatomists (AAA) Young Faculty Travel Award, FASEB meeting, New Orleans.

Selected Publications

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Categories: Faculty, Toxicology
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