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Patrick Sinko Ph.D.

Distinguished Professor and Associate Vice President for Research Rutgers University, Ernest Mario School of PharmacyEOHSI – Toxicology
Work William Levine Hall Room 225C 160 Frelinghuysen Road Piscataway NJ 08854 Work Phone: 848-445-6398 Work Fax: 732-445-4271
Photo of Patrick Sinko Ph.D.

Biographical Info

Research Areas

Drug delivery and targeting with an emphasis on AIDS, cancer, and chemical counterterrorism, biomaterials, hydrogels and nanocarriers, mechanism-based pharmacokinetics and biopharmaceutics; transport and metabolism, and bioavailability.

Research Highlights

Dr. Sinko’s research is focused on the mechanisms and applications of biopharmaceutics and polymers to drug delivery and targeting. His laboratory is located in the Ernest Mario School of Pharmacy. His group’s research efforts focus on the design, fabrication and evaluation of molecular-scale drug and diagnostic delivery technologies applied broadly to asthma, AIDS, cancer, and chemical counterterrorism. Dr. Sinko’s research efforts have been continuously supported by the National Institutes of Health, various nonprofit organizations and the Pharmaceutical and Biotech industries.

The research group is organized into therapeutic areas focusing on AIDS, cancer, and chemical counter-terrorism. Drug delivery at the molecular scale (i.e., nano) using biodegradable and biocompatible polymer platforms is a central theme. The scope of current projects includes a molecular mechanistic component, chemical design and synthesis, and biological and efficacy characterization (in vitro, in situ, and in vivo) with an emphasis on translation from concept to clinic.

Scholarly Activities

  • 2006 MERIT (Method to Extend Research in Time) Award, National Institutes of Health, for grant: Enhancing Intestinal & Brain Uptake of Anti-AIDS Drugs (R37 AI/DK-51214). The NIH awards MERIT status “to a select number of funded investigators (<5%) who have demonstrated superior competence, outstanding productivity during their previous research endeavors and are leaders in their field with paradigm-shifting ideas. The MERIT award runs through 2016.
  • 2003 Parke-Davis Endowed Chair in Pharmaceutics and Drug Delivery, School of Pharmacy, Rutgers University.
  • 2003 elected Fellow, American Association of Pharmaceutical Scientists, (Alexandria, VA).
  • 1999 Gallo Award for Outstanding Cancer Research (with Drs. F.R. Luo, E. Rubin and A.K. Lalloo, and P.V. Paranjpe).
  • 1997 Gallo Award for Outstanding Cancer Research (with Drs. E. Gupta, T. Cook, and E. Rubin).
  • 1997 Controlled Release Society, Inc., CRS-Dow Corning Recognition Award for Excellence in Guiding Graduate Student Research.
  • 1995 Hoechst Celanese Innovative Research Award.
  • 1994 Outstanding Teacher of the Year, Rutgers College Parents Association, Rutgers University.
  • 1993 American Association of Pharmaceutical Scientists (AAPS) Young Investigator Grant in Pharmaceutics and the Pharmaceutical Technologies.
  • 1992 Eli Lilly Young Investigator Award in Pharmaceutics.
  • 1992 Burroughs Welcome Fund New Investigator Award, American Association of Colleges of Pharmacy.

Recent Publications

  1. Kassa, C, Reményi, P, Sinkó, J, Kállay, K, Kertész, G, Kriván, G. Successful nivolumab therapy in an allogeneic stem cell transplant child with post-transplant lymphoproliferative disorder. Pediatr Transplant. 2018; :e13302. doi: 10.1111/petr.13302. PubMed PMID:30345623
  2. Gomez, L, Xu, R, Sinko, W, Selfridge, B, Vernier, W, Ly, K, Truong, R, Metz, M, Marrone, T, Sebring, K et al.. Mathematical and Structural Characterization of Strong Nonadditive Structure-Activity Relationship Caused by Protein Conformational Changes. J. Med. Chem. 2018;61 (17):7754-7766. doi: 10.1021/acs.jmedchem.8b00713. PubMed PMID:30070482
  3. Marino, RJ, Sinko, R, Bryden, A, Backus, D, Chen, D, Nemunaitis, GA, Leiby, BE. Comparison of Responsiveness and Minimal Clinically Important Difference of the Capabilities of Upper Extremity Test (CUE-T) and the Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP). Top Spinal Cord Inj Rehabil. 2018;24 (3):227-238. doi: 10.1310/sci2403-227. PubMed PMID:29997426 PubMed Central PMC6037321
  4. Hansoge, NK, Huang, T, Sinko, R, Xia, W, Chen, W, Keten, S. Materials by Design for Stiff and Tough Hairy Nanoparticle Assemblies. ACS Nano. 2018;12 (8):7946-7958. doi: 10.1021/acsnano.8b02454. PubMed PMID:29975847
  5. Málly, J, Stone, TW, Sinkó, G, Geisz, N, Dinya, E. Long term follow-up study of non-invasive brain stimulation (NBS) (rTMS and tDCS) in Parkinson's disease (PD). Strong age-dependency in the effect of NBS. Brain Res. Bull. 2018;142 :78-87. doi: 10.1016/j.brainresbull.2018.06.014. PubMed PMID:29958911
  6. Borbás, E, Tőzsér, P, Tsinman, K, Tsinman, O, Takács-Novák, K, Völgyi, G, Sinkó, B, Nagy, ZK. Effect of Formulation Additives on Drug Transport through Size-Exclusion Membranes. Mol. Pharm. 2018;15 (8):3308-3317. doi: 10.1021/acs.molpharmaceut.8b00343. PubMed PMID:29957955
  7. Hens, B, Sinko, PD, Job, N, Dean, M, Al-Gousous, J, Salehi, N, Ziff, RM, Tsume, Y, Bermejo, M, Paixão, P et al.. Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project. Int J Pharm. 2018;548 (1):120-127. doi: 10.1016/j.ijpharm.2018.06.050. PubMed PMID:29944899
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Categories: Faculty, Toxicology
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