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Lauren Aleksunes , Pharm.D., Ph.D., D.A.B.T.

Professor Rutgers University – Ernest Mario School of PharmacyEOHSI – Toxicology
Photo of Lauren Aleksunes Pharm.D., Ph.D., D.A.B.T.

Biography

Lauren Aleksunes’Lab 

Recent Publications

  1. Galetin, A, Brouwer, KLR, Tweedie, D, Yoshida, K, Sjöstedt, N, Aleksunes, L, Chu, X, Evers, R, Hafey, MJ, Lai, Y et al.. Membrane transporters in drug development and as determinants of precision medicine. Nat Rev Drug Discov. 2024; :. doi: 10.1038/s41573-023-00877-1. PubMed PMID:38267543
  2. Kozlosky, D, Doherty, C, Buckley, B, Goedken, MJ, Miller, RK, Huh, DD, Barrett, ES, Aleksunes, LM. Fetoplacental Disposition and Toxicity of Cadmium in Mice Lacking the Bcrp Transporter. Toxicol Sci. 2023;197 (2):132-46. doi: 10.1093/toxsci/kfad115. PubMed PMID:37941438 PubMed Central PMC10823776
  3. Zhang, R, Walker, L, Wen, X, Doherty, C, Gorczyca, L, Buckley, B, Barrett, ES, Aleksunes, LM. Placental BCRP transporter reduces cadmium accumulation and toxicity in immortalized human trophoblasts. Reprod Toxicol. 2023;121 :108466. doi: 10.1016/j.reprotox.2023.108466. PubMed PMID:37660740 PubMed Central PMC10591833
  4. Russo, DP, Aleksunes, LM, Goyak, K, Qian, H, Zhu, H. Integrating Concentration-Dependent Toxicity Data and Toxicokinetics To Inform Hepatotoxicity Response Pathways. Environ Sci Technol. 2023;57 (33):12291-12301. doi: 10.1021/acs.est.3c02792. PubMed PMID:37566783 PubMed Central PMC10448720
  5. Rivera-Núñez, Z, Hansel, M, Capurro, C, Kozlosky, D, Wang, C, Doherty, CL, Buckley, B, Ohman-Strickland, P, Miller, RK, O'Connor, TG et al.. Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy. Toxics. 2023;11 (7):. doi: 10.3390/toxics11070589. PubMed PMID:37505555 PubMed Central PMC10384739
  6. Kozlosky, D, Lu, A, Doherty, C, Buckley, B, Goedken, MJ, Miller, RK, Barrett, ES, Aleksunes, LM. Cadmium reduces growth of male fetuses by impairing development of the placental vasculature and reducing expression of nutrient transporters. Toxicol Appl Pharmacol. 2023;475 :116636. doi: 10.1016/j.taap.2023.116636. PubMed PMID:37487938 PubMed Central PMC10528997
  7. Lazofsky, A, Brinker, A, Gupta, R, Barrett, E, Aleksunes, LM, Rivera-Núñez, Z, Buckley, B. Optimized extraction and analysis methods using liquid chromatography-tandem mass spectrometry for zearalenone and metabolites in human placental tissue. Heliyon. 2023;9 (6):e16940. doi: 10.1016/j.heliyon.2023.e16940. PubMed PMID:37484340 PubMed Central PMC10361036
  8. Mosquera, AM, Aleksunes, LM. Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website. CourseSource. 2023;10 :. doi: 10.24918/cs.2023.10. PubMed PMID:37476533 PubMed Central PMC10357923
  9. Coyte, RM, Darrah, T, Olesik, J, Barrett, E, O'Connor, TG, Brunner, J, Love, T, Perez-D'Gregorio, R, Wang, HZ, Aleksunes, LM et al.. Gadolinium during human pregnancy following administration of gadolinium chelate before pregnancy. Birth Defects Res. 2023;115 (14):1264-1273. doi: 10.1002/bdr2.2209. PubMed PMID:37334869
  10. Chung, E, Russo, DP, Ciallella, HL, Wang, YT, Wu, M, Aleksunes, LM, Zhu, H. Data-Driven Quantitative Structure-Activity Relationship Modeling for Human Carcinogenicity by Chronic Oral Exposure. Environ Sci Technol. 2023;57 (16):6573-6588. doi: 10.1021/acs.est.3c00648. PubMed PMID:37040559 PubMed Central PMC10134506
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