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Jay A Tischfield Ph.D.

Distinguished Professor Rutgers University, School of Arts and SciencesEOHSI – Toxicology
Work Life Sciences Building Room 136 145 Bevier Road Piscataway NJ 08854 Work Phone: 732-445-1027 Work Fax: 732-445-1147
Photo of Jay A Tischfield Ph.D.

Biographical Info

Research Areas

Our primary research interests include studies of both somatically heritable and transient genetic changes in somatic cells that predispose to disease in humans. In addition, we are engaged in several large projects whose ultimate goal is the identification of genes that have major contributions to complex oligogenic disorders.

Research Highlights

Loss of heterozygosity (LOH) for tumor suppressor genes in somatic cells frequently results in a recessive cellular phenotype that leads to cancer. We have studied the frequency and mechanisms of LOH in human heterozygotes and produced a heterozygous mouse model for investigation of LOH in different genetic backgrounds and after exposure to environmental agents. We have discovered that the major mechanisms for LOH in normal cells are mitotic recombination, followed by point mutation. Thus, we are investigating genes (e.g., Tp53, Mlh1, Msh2) and environmental agents that may affect these processes. The mouse is an excellent model for this research due to the availability of many “knockouts” for genes that might affect LOH and our ability to deliver environmental agents, such as chemicals and radiation, in a precise manner.

Our group has also produced a knockout mouse model for APRT deficiency, which produces a human genetic disease (dihydroxyadenine urolithiasis) characterized by severe kidney stones and, in rare cases, chronic renal failure. We are comparing gene expression in mice with and without kidney stones in order to identify genes that are involved in early and late pathological changes. Thus far, the expression of several known and novel genes has been shown to increase or decrease with stone disease. We are investigating the expression of these genes in specific kidney cell types and correlating it with pathologic changes. Such studies may produce new targets for early pharmacologic intervention in the progression of kidney stone disease.

We are collaborating in several large, multidisciplinary projects whose goal is the identification and characterization of genes that make major contributions to complex human diseases such as alcoholism, opiate addiction, autism, schizophrenia and bipolar disorder. We are collecting blood and producing cell lines and DNA from large numbers of individuals in families with a high incidence of a specific disorder in an effort to find such genes.

Recent Publications

  1. Wetherill, L, Lai, D, Johnson, EC, Anokhin, A, Bauer, L, Bucholz, KK, Dick, DM, Hariri, AR, Hesselbrock, V, Kamarajan, C et al.. ERRATUM: Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans. Genes Brain Behav. 2019;18 (8):e12608. doi: 10.1111/gbb.12608. PubMed PMID:31667958
  2. Meyers, JL, Chorlian, DB, Johnson, EC, Pandey, AK, Kamarajan, C, Salvatore, JE, Aliev, F, Subbie-Saenz de Viteri, S, Zhang, J, Chao, M et al.. Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood. Brain Sci. 2019;9 (10):. doi: 10.3390/brainsci9100280. PubMed PMID:31627376
  3. Halikere, A, Popova, D, Scarnati, MS, Hamod, A, Swerdel, MR, Moore, JC, Tischfield, JA, Hart, RP, Pang, ZP. Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons. Mol. Psychiatry. 2019; :. doi: 10.1038/s41380-019-0507-0. PubMed PMID:31481756
  4. Rao, X, Thapa, KS, Chen, AB, Lin, H, Gao, H, Reiter, JL, Hargreaves, KA, Ipe, J, Lai, D, Xuei, X et al.. Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders. Mol. Psychiatry. 2019; :. doi: 10.1038/s41380-019-0508-z. PubMed PMID:31477794
  5. Lai, D, Wetherill, L, Kapoor, M, Johnson, EC, Schwandt, M, Ramchandani, VA, Goldman, D, Joslyn, G, Rao, X, Liu, Y et al.. Genome-wide association studies of the self-rating of effects of ethanol (SRE). Addict Biol. 2019; :e12800. doi: 10.1111/adb.12800. PubMed PMID:31270906
  6. Vazquez, BN, Thackray, JK, Simonet, NG, Chahar, S, Kane-Goldsmith, N, Newkirk, SJ, Lee, S, Xing, J, Verzi, MP, An, W et al.. SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina. Nucleic Acids Res. 2019;47 (15):7870-7885. doi: 10.1093/nar/gkz519. PubMed PMID:31226208 PubMed Central PMC6735864
  7. Woodard, LE, Welch, RC, Veach, RA, Beckermann, TM, Sha, F, Weinman, EJ, Ikizler, TA, Tischfield, JA, Sahota, A, Wilson, MH et al.. Metabolic consequences of cystinuria. BMC Nephrol. 2019;20 (1):227. doi: 10.1186/s12882-019-1417-8. PubMed PMID:31221135 PubMed Central PMC6585015
  8. Wetherill, L, Lai, D, Johnson, EC, Anokhin, A, Bauer, L, Bucholz, KK, Dick, DM, Hariri, AR, Hesselbrock, V, Kamarajan, C et al.. Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans. Genes Brain Behav. 2019;18 (6):e12580. doi: 10.1111/gbb.12580. PubMed PMID:31099175 PubMed Central PMC6726116
  9. Lai, D, Wetherill, L, Bertelsen, S, Carey, CE, Kamarajan, C, Kapoor, M, Meyers, JL, Anokhin, AP, Bennett, DA, Bucholz, KK et al.. Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria. Genes Brain Behav. 2019;18 (6):e12579. doi: 10.1111/gbb.12579. PubMed PMID:31090166 PubMed Central PMC6612573
  10. Aijaz, A, Li, M, Smith, D, Khong, D, LeBlon, C, Fenton, OS, Olabisi, RM, Libutti, S, Tischfield, J, Maus, MV et al.. Biomanufacturing for clinically advanced cell therapies. Nat Biomed Eng. 2018;2 (6):362-376. doi: 10.1038/s41551-018-0246-6. PubMed PMID:31011198 PubMed Central PMC6594100
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Categories: Faculty, Toxicology
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