Ioannis Androulakis Ph.D.Professor Rutgers University – School of EngineeringEOHSI – Exposure Science and Epidemiology
Dr. Androulakis received his B.S. in Chemical Engineering from the National Technical University of Athens, Greece, and he subsequently obtained his M.S and Ph.D. from Purdue University, USA. He spent two years at Princeton University as a research associate before joining ExxonMobil’s Corporate Strategic Research Laboratories, where he eventually became the Informatics and Knowledge Capitalization technical project leader before joining the Departments of Biomedical Engineering and Chemical & Biochemical Engineering at Rutgers University. His work has been funded by the US Environmental Protection Agency, the National Science Foundation, the Office of Naval Research, and the National Institutes of Health.
Dr. Androulakis actively pursues research activities in the area of Systems Biology, loosely defined as an integrative modeling and experimental framework that approaches biological entities as “systems” in the physical and engineering sense. Of particular interest are issues related to “functional physiomics” in an attempt to establish functional links between cellular events, such as signaling, transcription and translation, and an expanding envelope of interactions which include the bidirectional links between cells, tissues, organs, environmental signals and physiological responses. The ultimate goal is to develop in silico methodologies that will enable translational research by elucidating putative mechanisms by which macroscopic responses, at the physiome level, can be functionally modulated through mechanistic interventions. Of particular importance are the opportunities of such an integrative approach applied to the inflammatory responses due to the critical role inflammation plays in a number of physiologically and clinically relevant situations. His work integrates a compendium of experimental systems, from cell cultures, to animal models, to human studies in order to address different questions at their appropriate level of detail.
For more information: http://www.ipandro.com/
- Zhang, C, Wang, C, Li, W, Wu, R, Guo, Y, Cheng, D, Yang, Y, Androulakis, IP, Kong, AN. Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes. Mol. Pharm. 2017;14 (11):3709-3717. doi: 10.1021/acs.molpharmaceut.7b00469. PubMed PMID:29035547 PubMed Central PMC5697757
- Pierre, K, Schlesinger, N, Androulakis, IP. The Hepato-Hypothalamic-Pituitary-Adrenal-Renal Axis: Mathematical Modeling of Cortisol's Production, Metabolism, and Seasonal Variation. J. Biol. Rhythms. 2017;32 (5):469-484. doi: 10.1177/0748730417729929. PubMed PMID:28946788
- Rao, RT, Androulakis, IP. Modeling the Sex Differences and Interindividual Variability in the Activity of the Hypothalamic-Pituitary-Adrenal Axis. Endocrinology. 2017;158 (11):4017-4037. doi: 10.1210/en.2017-00544. PubMed PMID:28938475 PubMed Central PMC5695828
- Acevedo, A, Androulakis, IP. Allostatic breakdown of cascading homeostat systems: A computational approach. Heliyon. 2017;3 (7):e00355. doi: 10.1016/j.heliyon.2017.e00355. PubMed PMID:28761937 PubMed Central PMC5522379
- Bae, SA, Androulakis, IP. The Synergistic Role of Light-Feeding Phase Relations on Entraining Robust Circadian Rhythms in the Periphery. Gene Regul Syst Bio. 2017;11 :1177625017702393. doi: 10.1177/1177625017702393. PubMed PMID:28469414 PubMed Central PMC5404903
- Kamisoglu, K, Acevedo, A, Almon, RR, Coyle, S, Corbett, S, Dubois, DC, Nguyen, TT, Jusko, WJ, Androulakis, IP. Understanding Physiology in the Continuum: Integration of Information from Multiple -Omics Levels. Front Pharmacol. 2017;8 :91. doi: 10.3389/fphar.2017.00091. PubMed PMID:28289389 PubMed Central PMC5327699
- Hartmanshenn, C, Scherholz, M, Androulakis, IP. Physiologically-based pharmacokinetic models: approaches for enabling personalized medicine. J Pharmacokinet Pharmacodyn. 2016;43 (5):481-504. doi: 10.1007/s10928-016-9492-y. PubMed PMID:27647273 PubMed Central PMC5204363