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Ioannis Androulakis Ph.D.

Professor Rutgers University – School of EngineeringEOHSI – Exposure Science and Epidemiology
Address BME Building Room 212 599 Taylor Road Piscataway NJ 08854 Phone: 848-445-6561 Fax: 732-445-3753
Photo of Ioannis Androulakis Ph.D.

Biographical Info

Dr. Androulakis received his B.S. in Chemical Engineering from the National Technical University of Athens, Greece, and he subsequently obtained his M.S and Ph.D. from Purdue University, USA. He spent two years at Princeton University as a research associate before joining ExxonMobil’s Corporate Strategic Research Laboratories, where he eventually became the Informatics and Knowledge Capitalization technical project leader before joining the Departments of Biomedical Engineering and Chemical & Biochemical Engineering at Rutgers University. His work has been funded by the US Environmental Protection Agency, the National Science Foundation, the Office of Naval Research, and the National Institutes of Health.

Dr. Androulakis actively pursues research activities in the area of Systems Biology, loosely defined as an integrative modeling and experimental framework that approaches biological entities as “systems” in the physical and engineering sense. Of particular interest are issues related to “functional physiomics” in an attempt to establish functional links between cellular events, such as signaling, transcription and translation, and an expanding envelope of interactions which include the bidirectional links between cells, tissues, organs, environmental signals and physiological responses. The ultimate goal is to develop in silico methodologies that will enable translational research by elucidating putative mechanisms by which macroscopic responses, at the physiome level, can be functionally modulated through mechanistic interventions. Of particular importance are the opportunities of such an integrative approach applied to the inflammatory responses due to the critical role inflammation plays in a number of physiologically and clinically relevant situations. His work integrates a compendium of experimental systems, from cell cultures, to animal models, to human studies in order to address different questions at their appropriate level of detail.

For more information: http://www.ipandro.com/

Recent Publications

  1. Boyanapalli, SSS, Huang, Y, Su, Z, Cheng, D, Zhang, C, Guo, Y, Rao, R, Androulakis, IP, Kong, AN. Pharmacokinetics and Pharmacodynamics of Curcumin in regulating anti-inflammatory and epigenetic gene expression. Biopharm Drug Dispos. 2018; :. doi: 10.1002/bdd.2136. PubMed PMID:29870054
  2. Pierre, K, Rao, RT, Hartmanshenn, C, Androulakis, IP. Modeling the Influence of Seasonal Differences in the HPA Axis on Synchronization of the Circadian Clock and Cell Cycle. Endocrinology. 2018;159 (4):1808-1826. doi: 10.1210/en.2017-03226. PubMed PMID:29444258 PubMed Central PMC6044315
  3. Scherholz, ML, Forder, J, Androulakis, IP. A framework for 2-stage global sensitivity analysis of GastroPlus™ compartmental models. J Pharmacokinet Pharmacodyn. 2018;45 (2):309-327. doi: 10.1007/s10928-018-9573-1. PubMed PMID:29423863
  4. Rao, RT, Scherholz, ML, Hartmanshenn, C, Bae, SA, Androulakis, IP. On the analysis of complex biological supply chains: From Process Systems Engineering to Quantitative Systems Pharmacology. Comput Chem Eng. 2017;107 :100-110. doi: 10.1016/j.compchemeng.2017.06.003. PubMed PMID:29353945 PubMed Central PMC5773066
  5. Bae, SA, Androulakis, IP. Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis: the intertwining entraining roles of light and feeding. Am. J. Physiol. Endocrinol. Metab. 2018;314 (6):E531-E542. doi: 10.1152/ajpendo.00271.2017. PubMed PMID:29351477 PubMed Central PMC6032066
  6. Zhang, C, Wang, C, Li, W, Wu, R, Guo, Y, Cheng, D, Yang, Y, Androulakis, IP, Kong, AN. Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes. Mol. Pharm. 2017;14 (11):3709-3717. doi: 10.1021/acs.molpharmaceut.7b00469. PubMed PMID:29035547 PubMed Central PMC5697757
  7. Pierre, K, Schlesinger, N, Androulakis, IP. The Hepato-Hypothalamic-Pituitary-Adrenal-Renal Axis: Mathematical Modeling of Cortisol's Production, Metabolism, and Seasonal Variation. J. Biol. Rhythms. 2017;32 (5):469-484. doi: 10.1177/0748730417729929. PubMed PMID:28946788
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Categories: Faculty, Exposure Science and Epidemiology

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